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Zfy2 zinc finger protein 2, Y-linked [ Mus musculus (house mouse) ]

Gene ID: 22768, updated on 4-Jan-2025

Summary

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Official Symbol
Zfy2provided by MGI
Official Full Name
zinc finger protein 2, Y-linkedprovided by MGI
Primary source
MGI:MGI:99213
See related
Ensembl:ENSMUSG00000000103 AllianceGenome:MGI:99213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfy-2
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within dosage compensation by inactivation of X chromosome; meiotic recombination checkpoint signaling; and spermatid development. Predicted to be located in nucleus. Is expressed in heart; liver; lung; metanephros; and reproductive system. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis adult (RPKM 1.1) See more
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Genomic context

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See Zfy2 in Genome Data Viewer
Location:
Y; Ypter
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (2106175..2170409, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (2106175..2170409, complement)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene ras homolog A translocated to the Y, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_48305 Neighboring gene ubiquitin-activating enzyme, Chr Y, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_48306 Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New assays for Y chromosome and p53 pseudogene clines among East Holstein house mice. Prager EM, et al. Mamm Genome, 1997 Apr. PMID 9096111
  2. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Su H, et al. Mol Reprod Dev, 1992 Nov. PMID 1449792
  3. Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction. Nakasuji T, et al. PLoS Genet, 2017 Jan. PMID 28114340, Free PMC Article
  4. The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers. Mardon G, et al. Cell, 1989 Mar 10. PMID 2493989
  5. A genomic clone of Zfy-1 from a YDOM mouse strain detects post-meiotic gene expression of Zfy in testes. Kalikin LM, et al. Biochem Biophys Res Commun, 1989 Dec 29. PMID 2514683

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
    Title: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
  2. we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also necessary for efficient meiotic sex chrand the sex chromosomes are not correctly silenced in Zfy-deficient spermatocytes.
    Title: Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.
  3. Zfy2-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
    Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
  4. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development
    Title: Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development.
  5. Zfy2 is essential for sperm formation and is essential for sperm function in assisted fertilization procedure.
    Title: Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization.
  6. Zfy2 proved to be essential for the efficient operation of a 'checkpoint' during the first meiotic division that identifies and kills cells that would otherwise produce sperm with an unbalanced chromosome set.
    Title: Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
  7. The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
    Title: The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
  8. Studies identified a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain.
    Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
  9. Zfy2 (but not the closely related Zfy1) is sufficient to reinstate the apoptotic response to the X univalent meiotic cell.
    Title: The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within meiotic recombination checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger Y-chromosomal protein 2
Names
Y-linked zinc finger protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009571.2 → NP_033597.2  zinc finger Y-chromosomal protein 2

    See identical proteins and their annotated locations for NP_033597.2

    Status: PROVISIONAL

    Source sequence(s)
    AK133222
    Consensus CDS
    CCDS41217.1
    UniProtKB/Swiss-Prot
    P20662, Q3V0D8
    Related
    ENSMUSP00000111557.2, ENSMUST00000115891.2
    Conserved Domains (6) summary
    COG5048
    Location:442 → 681
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:520 → 542
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:68 → 388
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:534 → 556
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    2106175..2170409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318690.2 → XP_017174179.1  zinc finger Y-chromosomal protein 2 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:427 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:42 → 373
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20662.2 GenPept UniProtKB/Swiss-Prot:P20662

Gene LinkOut

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