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Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 [ Mus musculus (house mouse) ]

Gene ID: 227731, updated on 27-Nov-2024

Summary

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Official Symbol
Slc25a25provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25provided by MGI
Primary source
MGI:MGI:1915913
See related
Ensembl:ENSMUSG00000026819 AllianceGenome:MGI:1915913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCSC; SCaMC-2; mKIAA1896; 1110030N17Rik
Summary
Predicted to enable ATP:phosphate antiporter activity. Acts upstream of or within several processes, including response to activity; response to dietary excess; and response to food. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 15.8), cerebellum adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc25a25 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32304499..32341482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32414487..32451470, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2612 Neighboring gene prostaglandin E synthase 2 Neighboring gene predicted gene 13413 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Nakao R, et al. Sci Rep, 2017 Jun 6. PMID 28588221, Free PMC Article
  2. Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice. Anunciado-Koza RP, et al. J Biol Chem, 2011 Apr 1. PMID 21296886, Free PMC Article
  3. Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. Amigo I, et al. J Biol Chem, 2013 Mar 15. PMID 23344948, Free PMC Article
  4. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. del Arco A, et al. J Biol Chem, 2004 Jun 4. PMID 15054102
  5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals.
    Title: Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis.
  2. induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress.
    Title: Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36388

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP:phosphate antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ATP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to dietary excess IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to food IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial adenyl nucleotide antiporter SLC25A25
Names
calcium-binding mitochondrial carrier protein SCaMC-2
mitochondrial Ca2+-dependent solute carrier
short calcium-binding mitochondrial carrier protein 2
small calcium-binding mitochondrial carrier protein 2
solute carrier family 25 member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164357.1 → NP_001157829.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 2

    See identical proteins and their annotated locations for NP_001157829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK132204, BB653459, CO043296
    Consensus CDS
    CCDS50568.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000108936.3, ENSMUST00000113310.9
    Conserved Domains (3) summary
    cd00051
    Location:115 → 174
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:309 → 401
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:52 → 109
    EF-hand_7; EF-hand domain pair

  2. NM_001164358.1 → NP_001157830.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 3

    See identical proteins and their annotated locations for NP_001157830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC066998, CV784232
    Consensus CDS
    CCDS50567.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000060581.8, ENSMUST00000052119.14
    Conserved Domains (4) summary
    cd00051
    Location:102 → 173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:308 → 400
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:103 → 170
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:63 → 97
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_001290558.1 → NP_001277487.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 4

    See identical proteins and their annotated locations for NP_001277487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK049392, BC066998, BY772900
    Consensus CDS
    CCDS71028.1
    UniProtKB/Swiss-Prot
    A2ASZ1, A2ASZ5, A2ASZ8, A2ASZ9, Q6NXM8, Q80T78, Q8BHG0, Q8JZT8, Q8VBT4, Q99KD3
    Related
    ENSMUSP00000108932.3, ENSMUST00000113307.9
    Conserved Domains (4) summary
    cd00051
    Location:82 → 141
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:276 → 368
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:83 → 138
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:29 → 77
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. NM_001362905.1 → NP_001349834.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL928710
    Consensus CDS
    CCDS89474.1
    Related
    ENSMUSP00000108933.2, ENSMUST00000113308.8
    Conserved Domains (3) summary
    cd15897
    Location:73 → 97
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:73 → 159
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:211 → 465
    Mito_carr; Mitochondrial carrier protein

  5. NM_001362906.1 → NP_001349835.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL928710, BM947090
    Conserved Domains (5) summary
    cd15898
    Location:67 → 96
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:36 → 62
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:31 → 110
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:188 → 442
    Mito_carr; Mitochondrial carrier protein
    cl28895
    Location:67 → 156
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  6. NM_001362907.1 → NP_001349836.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL928710
    Conserved Domains (3) summary
    cd15897
    Location:36 → 62
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:31 → 124
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:176 → 430
    Mito_carr; Mitochondrial carrier protein

  7. NM_146118.3 → NP_666230.2  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 1

    See identical proteins and their annotated locations for NP_666230.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL928710
    Consensus CDS
    CCDS15915.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000028160.9, ENSMUST00000028160.15
    Conserved Domains (3) summary
    cd00051
    Location:53 → 110
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:321 → 413
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:52 → 109
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32304499..32341482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497955.5 → XP_006498018.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X1

    Conserved Domains (5) summary
    PTZ00169
    Location:203 → 457
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    cd15898
    Location:82 → 111
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:53 → 77
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:82 → 171
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:53 → 125
    EFh_PEF; The penta-EF hand (PEF) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ASZ8.1 GenPept UniProtKB/Swiss-Prot:A2ASZ8

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