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Zyx zyxin [ Mus musculus (house mouse) ]

Gene ID: 22793, updated on 27-Nov-2024

Summary

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Official Symbol
Zyxprovided by MGI
Official Full Name
zyxinprovided by MGI
Primary source
MGI:MGI:103072
See related
Ensembl:ENSMUSG00000029860 AllianceGenome:MGI:103072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530098H06Rik
Summary
Predicted to enable metal ion binding activity. Involved in cell-matrix adhesion; integrin-mediated signaling pathway; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion and phagocytic vesicle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and heart. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 88.7), ovary adult (RPKM 71.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zyx in Genome Data Viewer
Location:
6 B2.1; 6 20.64 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42326507..42337158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42349511..42360213)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene family with sequence similarity 131, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42293816-42293969 Neighboring gene predicted gene, 24611 Neighboring gene RIKEN cDNA 2010310C07 gene Neighboring gene Eph receptor A1 Neighboring gene STARR-seq mESC enhancer starr_15718 Neighboring gene taste receptor, type 2, member 143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface. Zhang S, et al. Commun Biol, 2023 Jan 18. PMID 36653484, Free PMC Article
  2. A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Stachowiak MR, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25422436, Free PMC Article
  3. Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Hoffman LM, et al. Mol Biol Cell, 2012 May. PMID 22456508, Free PMC Article
  4. The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Hervy M, et al. Genes Cancer, 2010 May 1. PMID 20852740, Free PMC Article
  5. A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Smith MA, et al. Dev Cell, 2010 Sep 14. PMID 20833360, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
    Title: Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
  2. Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
    Title: Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
  3. Zyxin protects from hypertension-induced cardiac dysfunction.
    Title: Zyxin protects from hypertension-induced cardiac dysfunction.
  4. Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
    Title: Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
  5. Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF.
    Title: Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
  6. these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.
    Title: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
  7. zyxin influences focal adhesion dynamics, that it recruits Tes and that this interaction is functional in regulating cell spreading.
    Title: Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.
  8. Zyxin contributes to the migratory and invasive phenotype evoked by Tead2.
    Title: Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
  9. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.
    Title: Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.
  10. paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites
    Title: LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zyxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289617.2 → NP_001276546.1  zyxin isoform a

    See identical proteins and their annotated locations for NP_001276546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS20066.1
    UniProtKB/Swiss-Prot
    P70461, Q3UGQ3, Q62523
    UniProtKB/TrEMBL
    Q3TCR9
    Related
    ENSMUSP00000126622.2, ENSMUST00000164375.4
    Conserved Domains (4) summary
    cd09353
    Location:436 → 495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496 → 562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:175 → 368
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:343 → 429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001289618.2 → NP_001276547.1  zyxin isoform b

    See identical proteins and their annotated locations for NP_001276547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS85034.1
    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Related
    ENSMUSP00000145236.2, ENSMUST00000203401.3
    Conserved Domains (4) summary
    cd09353
    Location:405 → 464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465 → 531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5 → 311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312 → 398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001289619.2 → NP_001276548.1  zyxin isoform b

    See identical proteins and their annotated locations for NP_001276548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS85034.1
    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Related
    ENSMUSP00000070427.8, ENSMUST00000070635.13
    Conserved Domains (4) summary
    cd09353
    Location:405 → 464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465 → 531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5 → 311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312 → 398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. NM_001415802.1 → NP_001402731.1  zyxin isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153915
    UniProtKB/Swiss-Prot
    P70461, Q3UGQ3, Q62523

  5. NM_011777.4 → NP_035907.1  zyxin isoform a

    See identical proteins and their annotated locations for NP_035907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS20066.1
    UniProtKB/Swiss-Prot
    P70461, Q3UGQ3, Q62523
    UniProtKB/TrEMBL
    Q3TCR9
    Related
    ENSMUSP00000145451.2, ENSMUST00000203652.3
    Conserved Domains (4) summary
    cd09353
    Location:436 → 495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496 → 562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:175 → 368
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:343 → 429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42326507..42337158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255327.2 → XP_030111187.1  zyxin isoform X2

    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Conserved Domains (4) summary
    cd09353
    Location:405 → 464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465 → 531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5 → 311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312 → 398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_036166031.1 → XP_036021924.1  zyxin isoform X2

    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Conserved Domains (4) summary
    cd09353
    Location:405 → 464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465 → 531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5 → 311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312 → 398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_036166032.1 → XP_036021925.1  zyxin isoform X3

    UniProtKB/TrEMBL
    Q8CD55
    Conserved Domains (4) summary
    cd09353
    Location:337 → 396
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:397 → 463
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:76 → 269
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:244 → 330
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62523.2 GenPept UniProtKB/Swiss-Prot:Q62523

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