Stoml3 stomatin (Epb7.2)-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stoml3provided by MGI
Official Full Name: stomatin (Epb7.2)-like 3provided by MGI
Primary source: MGI:MGI:2388072
See related: Ensembl:ENSMUSG00000027744 AllianceGenome:MGI:2388072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sro; SLP3; Epb7.2l
Summary: Acts upstream of or within signal transduction. Located in cilium; membrane raft; and neuron projection. Is expressed in olfactory epithelium. Orthologous to human STOML3 (stomatin like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 4.2), ovary adult (RPKM 1.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 25.21 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (53396128..53416284)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (53488707..53508863)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Conserved Role for Stomatin Domain Genes in Olfactory Behavior.
Title: A Conserved Role for Stomatin Domain Genes in Olfactory Behavior.
A Role for STOML3 in Olfactory Sensory Transduction.
Title: A Role for STOML3 in Olfactory Sensory Transduction.
STOML3 inhibitors in the skin also reversibly attenuate fine touch perception in normal mice.
Title: Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.
Title: Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
In C57BL/6N, but not STOML3(-/-) mice, tactile allodynia is attenuated by cholesterol depletion, suggesting that membrane stiffening by STOML3 is essential for mechanical sensitivity.
Title: Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons.
STOML3 is the first potent modulator of Piezo channels that tunes the sensitivity of mechanically gated channels to detect molecular-scale stimuli relevant for fine touch.
Title: Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.
Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.
Title: Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.
[review] Generation of stoml3-deficient mice demonstrates that murine STOML3 is functionally orthologous to the MEC-2 memrane protein.
Title: Stomatin-domain proteins.
SLP3 is therefore indispensable for the function of a subset of cutaneous mechanoreceptors, and our data support the idea that this protein is an essential subunit of a mammalian mechanotransducer
Title: A stomatin-domain protein essential for touch sensation in the mouse.
characterization of an olfactory neuronal protein, SLP3, which shares extensive homology with the stomatin family of membrane proteins; expressed selectively in the receptor neurons of the olfactory epithelium
Title: Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stomatin-like protein 3

Names: SLP-3; stomatin related olfactory protein SRO; stomatin-related olfactory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153156.2 → NP_694796.1 stomatin-like protein 3

See identical proteins and their annotated locations for NP_694796.1

Status: VALIDATED

Source sequence(s)

AC158162

Consensus CDS

CCDS17347.1

UniProtKB/Swiss-Prot

Q66JM3, Q6PE84, Q8K4P4

UniProtKB/TrEMBL

B2RS16

Related

ENSMUSP00000029307.4, ENSMUST00000029307.4

Conserved Domains (2) summary

smart00244
Location:45 → 200

PHB; prohibitin homologues

cl19107
Location:69 → 267

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily