Pbxip1 pre B cell leukemia transcription factor interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pbxip1provided by MGI
Official Full Name: pre B cell leukemia transcription factor interacting protein 1provided by MGI
Primary source: MGI:MGI:2441670
See related: Ensembl:ENSMUSG00000042613 AllianceGenome:MGI:2441670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4732463H20Rik
Summary: Enables transcription coactivator activity. Acts upstream of or within several processes, including articular cartilage development; extracellular matrix organization; and positive regulation of chondrocyte proliferation. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in brain; diaphragm; gut; heart ventricle; and spinal cord ventricular layer. Orthologous to human PBXIP1 (PBX homeobox interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 58.7), colon adult (RPKM 38.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.12 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89343982..89358259)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89436675..89450952)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hematopoietic PBX-interacting protein is a novel regulator of mammary epithelial cell differentiation.
Title: Hematopoietic PBX-interacting protein is a novel regulator of mammary epithelial cell differentiation.
HPIP promotes the transcription of Wnt targets by interacting with lymphoid enhancer binding factor 1 (LEF1). HPIP potentiates the transcriptional activity of LEF1 and acetylates histone H3 lysine 56 in the promoters of Wnt targets, suggesting that HPIP is an attractive target in OA regulatory network.
Title: Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.
mouse spermatogonial stem cells expressed Tex11, Hpip, and Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2 for binding to HPIP.
Title: TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within articular cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression involved in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within production of molecular mediator involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pre-B-cell leukemia transcription factor-interacting protein 1

Names: hematopoietic PBX-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146131.2 → NP_666243.1 pre-B-cell leukemia transcription factor-interacting protein 1

Status: VALIDATED

Source sequence(s)

AC171273, AK028858, AK047898, CD742482

Consensus CDS

CCDS17510.1

UniProtKB/Swiss-Prot

Q3TD91, Q3TVI8, Q3TWL9, Q8R319

Related

ENSMUSP00000040429.4, ENSMUST00000038942.10

Conserved Domains (1) summary

TIGR04211
Location:283 → 403

SH3_and_anchor; SH3 domain protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

89343982..89358259

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501351.2 → XP_006501414.1 pre-B-cell leukemia transcription factor-interacting protein 1 isoform X1

Conserved Domains (1) summary

TIGR04211
Location:290 → 410

SH3_and_anchor; SH3 domain protein
XM_006501353.3 → XP_006501416.1 pre-B-cell leukemia transcription factor-interacting protein 1 isoform X2

UniProtKB/Swiss-Prot

Q3TD91, Q3TVI8, Q3TWL9, Q8R319

Conserved Domains (1) summary

TIGR04211
Location:283 → 403

SH3_and_anchor; SH3 domain protein
XM_006501352.3 → XP_006501415.1 pre-B-cell leukemia transcription factor-interacting protein 1 isoform X1

Conserved Domains (1) summary

TIGR04211
Location:290 → 410

SH3_and_anchor; SH3 domain protein