Tdpoz8 TD and POZ domain containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tdpoz8provided by MGI
Official Full Name: TD and POZ domain containing 8provided by MGI
Primary source: MGI:MGI:3645677
See related: Ensembl:ENSMUSG00000096879 AllianceGenome:MGI:3645677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm4858; EG229571
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92976130..92982812)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (93068823..93075505)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Tdpoz4 (e-PCR), detects polymorphism
- UniSTS:265757

NoName (e-PCR)
- UniSTS:488671

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TD and POZ domain containing-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034860.2 → NP_001030032.1 TD and POZ domain containing-like isoform 2

See identical proteins and their annotated locations for NP_001030032.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice pattern and begins translation at a downstream start codon. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK139723

Consensus CDS

CCDS38523.1

UniProtKB/TrEMBL

Q3UT66

Related

ENSMUSP00000141574.2, ENSMUST00000194595.2

Conserved Domains (4) summary

smart00225
Location:63 → 161

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14734
Location:161 → 222

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:54 → 158

BTB; BTB/POZ domain

cl02446
Location:8 → 28

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001177694.1 → NP_001171165.1 TD and POZ domain containing-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform. The structure of the 5' UTR has not been determined.

Source sequence(s)

AC135289, BC172161

UniProtKB/TrEMBL

B7ZWN5

Related

ENSMUSP00000141677.2, ENSMUST00000195847.2

Conserved Domains (4) summary

smart00225
Location:189 → 287

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14734
Location:287 → 348

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:180 → 284

BTB; BTB/POZ domain

cl02446
Location:16 → 154

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...