Flg2 filaggrin family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flg2provided by MGI
Official Full Name: filaggrin family member 2provided by MGI
Primary source: MGI:MGI:3645678
See related: Ensembl:ENSMUSG00000049133 AllianceGenome:MGI:3645678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG229574
Summary: Predicted to enable calcium ion binding activity and transition metal ion binding activity. Predicted to be involved in cell adhesion; epidermis morphogenesis; and establishment of skin barrier. Is active in cornified envelope. Human ortholog(s) of this gene implicated in peeling skin syndrome 6. Orthologous to human FLG2 (filaggrin 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly
Expression: Restricted expression toward mammary gland adult (RPKM 2.7) See more
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Genomic context

Location:: 3 F2.1; 3 40.14 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (93104585..93128701)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (93197273..93221377)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In metabolically (essential fatty acid-deficient diet) induced skin barrier dysfunction, filaggrin-2 expression was significantly reduced, whereas filaggrin expression was up-regulated.
Title: Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epidermis morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of skin barrier	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in keratohyalin granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: filaggrin-2

Names: intermediate filament-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013804.2 → NP_001013826.2 filaggrin-2

Status: VALIDATED

Source sequence(s)

AC173113

UniProtKB/TrEMBL

A0AAA9WWH7

Related

ENSMUSP00000160002.1, ENSMUST00000194707.4

Conserved Domains (6) summary

PTZ00449
Location:5068 → 5373

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03247
Location:3872 → 4228

PHA03247; large tegument protein UL36; Provisional

PRK12678
Location:3477 → 3672

PRK12678; transcription termination factor Rho; Provisional

cd00213
Location:4 → 87

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

pfam03157
Location:4650 → 5161

Glutenin_hmw; High molecular weight glutenin subunit

NF033849
Location:680 → 971

ser_rich_anae_1; serine-rich protein