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Gpr61 G protein-coupled receptor 61 [ Mus musculus (house mouse) ]

Gene ID: 229714, updated on 27-Nov-2024

Summary

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Official Symbol
Gpr61provided by MGI
Official Full Name
G protein-coupled receptor 61provided by MGI
Primary source
MGI:MGI:2441719
See related
Ensembl:ENSMUSG00000046793 AllianceGenome:MGI:2441719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be part of receptor complex. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR61 (G protein-coupled receptor 61). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 3.4), cortex adult (RPKM 2.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr61 in Genome Data Viewer
Location:
3 F2.3; 3 46.84 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108055660..108062218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108148321..108154932, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12500 Neighboring gene G protein subunit alpha transducin 2 Neighboring gene G protein subunit alpha i3 Neighboring gene STARR-positive B cell enhancer ABC_E2092 Neighboring gene STARR-positive B cell enhancer ABC_E2093 Neighboring gene predicted gene, 40122 Neighboring gene adhesion molecule with Ig like domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor. Nambu H, et al. Life Sci, 2011 Nov 21. PMID 21971119
  2. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Xu W, et al. Int J Mol Sci, 2022 May 20. PMID 35628521, Free PMC Article
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that GPR61 is involved in the regulation of food intake and body weight
    Title: Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables arrestin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305461.2 → NP_001292390.1  G-protein coupled receptor 61

    See identical proteins and their annotated locations for NP_001292390.1

    Status: VALIDATED

    Source sequence(s)
    AL671854
    Consensus CDS
    CCDS17752.1
    UniProtKB/Swiss-Prot
    Q3UZR6, Q8C010
    Related
    ENSMUSP00000111988.2, ENSMUST00000116284.2
    Conserved Domains (1) summary
    cd15220
    Location:44 → 352
    7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001411298.1 → NP_001398227.1  G-protein coupled receptor 61

    Status: VALIDATED

    Source sequence(s)
    AL671854
    UniProtKB/Swiss-Prot
    Q3UZR6, Q8C010
    Related
    ENSMUSP00000055557.2, ENSMUST00000062028.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108055660..108062218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175470.4: Suppressed sequence

    Description
    NM_175470.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C010.2 GenPept UniProtKB/Swiss-Prot:Q8C010

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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