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Atosb atos homolog B [ Mus musculus (house mouse) ]

Gene ID: 230088, updated on 27-Nov-2024

Summary

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Official Symbol
Atosbprovided by MGI
Official Full Name
atos homolog Bprovided by MGI
Primary source
MGI:MGI:2441854
See related
Ensembl:ENSMUSG00000036002 AllianceGenome:MGI:2441854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam214b; B230312A22Rik
Summary
Predicted to be located in nucleus. Orthologous to human ATOSB (atos homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 19.2), small intestine adult (RPKM 18.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atosb in Genome Data Viewer
Location:
4 A5; 4 22.99 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43032414..43046220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43032414..43046220, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene STARR-positive B cell enhancer ABC_E6166 Neighboring gene stomatin (Epb7.2)-like 2 Neighboring gene STARR-seq mESC enhancer starr_10046 Neighboring gene unc-13 homolog B Neighboring gene STARR-seq mESC enhancer starr_10047 Neighboring gene predicted gene, 23709 Neighboring gene predicted gene, 25010

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. Werren EA, et al. Nat Commun, 2024 Feb 22. PMID 38388531, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1539

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atos homolog protein B
Names
family with sequence similarity 214, member B
protein FAM214B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253353.1 → NP_001240282.1  atos homolog protein B

    See identical proteins and their annotated locations for NP_001240282.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK149610, AL672276, BQ175731
    Consensus CDS
    CCDS18090.1
    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Related
    ENSMUSP00000103592.2, ENSMUST00000107958.8
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  2. NM_001253354.1 → NP_001240283.1  atos homolog protein B

    See identical proteins and their annotated locations for NP_001240283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL672276, BC046771
    Consensus CDS
    CCDS18090.1
    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Related
    ENSMUSP00000103593.2, ENSMUST00000107959.8
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  3. NM_172691.3 → NP_766279.1  atos homolog protein B

    See identical proteins and their annotated locations for NP_766279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK045811, BQ175731, BU702672
    Consensus CDS
    CCDS18090.1
    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Related
    ENSMUSP00000038177.6, ENSMUST00000036462.12
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

RNA

  1. NR_045567.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an internal exon, compare to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC054736
    Related
    ENSMUST00000135067.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43032414..43046220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537824.1 → XP_006537887.1  atos homolog protein B isoform X1

    See identical proteins and their annotated locations for XP_006537887.1

    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Related
    ENSMUSP00000103591.2, ENSMUST00000107957.8
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  2. XM_011249994.2 → XP_011248296.1  atos homolog protein B isoform X1

    See identical proteins and their annotated locations for XP_011248296.1

    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Related
    ENSMUSP00000103590.2, ENSMUST00000107956.8
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  3. XM_030253415.1 → XP_030109275.1  atos homolog protein B isoform X2

    Conserved Domains (2) summary
    pfam13889
    Location:479 → 535
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:347 → 397
    DUF4210; Domain of unknown function (DUF4210)

  4. XM_006537822.3 → XP_006537885.1  atos homolog protein B isoform X1

    See identical proteins and their annotated locations for XP_006537885.1

    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  5. XM_030253413.2 → XP_030109273.1  atos homolog protein B isoform X2

    Conserved Domains (2) summary
    pfam13889
    Location:479 → 535
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:347 → 397
    DUF4210; Domain of unknown function (DUF4210)

  6. XM_030253416.2 → XP_030109276.1  atos homolog protein B isoform X2

    Conserved Domains (2) summary
    pfam13889
    Location:479 → 535
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:347 → 397
    DUF4210; Domain of unknown function (DUF4210)

  7. XM_030253414.2 → XP_030109274.1  atos homolog protein B isoform X2

    Conserved Domains (2) summary
    pfam13889
    Location:479 → 535
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:347 → 397
    DUF4210; Domain of unknown function (DUF4210)

  8. XM_006537823.4 → XP_006537886.1  atos homolog protein B isoform X1

    See identical proteins and their annotated locations for XP_006537886.1

    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  9. XM_017320125.3 → XP_017175614.1  atos homolog protein B isoform X1

    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)

  10. XM_030253412.2 → XP_030109272.1  atos homolog protein B isoform X1

    UniProtKB/Swiss-Prot
    B0QZW6, Q3TTG5, Q3U3I3, Q3UEC3, Q69ZG9, Q6IR39, Q8BR27
    Conserved Domains (2) summary
    pfam13889
    Location:480 → 536
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:348 → 398
    DUF4210; Domain of unknown function (DUF4210)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BR27.1 GenPept UniProtKB/Swiss-Prot:Q8BR27

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