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ZHX3 zinc fingers and homeoboxes 3 [ Homo sapiens (human) ]

Gene ID: 23051, updated on 27-Nov-2024

Summary

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Official Symbol
ZHX3provided by HGNC
Official Full Name
zinc fingers and homeoboxes 3provided by HGNC
Primary source
HGNC:HGNC:15935
See related
Ensembl:ENSG00000174306 MIM:609598; AllianceGenome:HGNC:15935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIX1
Summary
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 8.0), brain (RPKM 7.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZHX3 in Genome Data Viewer
Location:
20q12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (41178455..41317731, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (42910141..43049531, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (39807095..39946371, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PLCG1 antisense RNA 1 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39764698-39765482 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:39766267-39767051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39774494-39774994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39774995-39775495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39786713-39787233 Neighboring gene phospholipase C gamma 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17891 Neighboring gene microRNA 6871 Neighboring gene ribosomal protein L23a pseudogene 81 Neighboring gene RNA, 7SL, cytoplasmic 615, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17893 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:39962705-39962931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:39975675-39976198 Neighboring gene acireductone dioxygenase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39986695-39987302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39987303-39987910 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation. Igata T, et al. PLoS One, 2022. PMID 35085309, Free PMC Article
  2. Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation. Suehiro F, et al. Stem Cells Dev, 2011 Sep. PMID 21174497
  3. ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21. Deng M, et al. Cancer Sci, 2021 May. PMID 33440047, Free PMC Article
  4. Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma. Kwon RJ, et al. PLoS One, 2017. PMID 28152006, Free PMC Article
  5. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. Kawata H, et al. Gene, 2003 Dec 24. PMID 14659886

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation.
    Title: Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation.
  2. ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21.
    Title: ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21.
  3. ZHX3 expression in renal cell carcinoma
    Title: Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.
  4. ZHX3 is involved in the switch from the undifferentiated state of mesenchymal stem cells to an osteogenic program
    Title: Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation.
  5. ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease
    Title: ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
  6. dimerizes with both ZHX1 and ZHX3, also interacts with the activation domain of the NF-YA
    Title: Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0395

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc fingers and homeoboxes protein 3
Names
triple homeobox 1
triple homeobox protein 1
zinc finger and homeodomain protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046923.1 RefSeqGene

    Range
    4888..144164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384315.1 → NP_001371244.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  2. NM_001384316.1 → NP_001371245.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Related
    ENSP00000452965.1, ENST00000559234.5
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  3. NM_001384317.1 → NP_001371246.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Related
    ENSP00000506788.1, ENST00000683867.1
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  4. NM_001384318.1 → NP_001371247.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  5. NM_001384319.1 → NP_001371248.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  6. NM_001384320.1 → NP_001371249.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  7. NM_001384321.1 → NP_001371250.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  8. NM_001384322.1 → NP_001371251.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  9. NM_001384323.1 → NP_001371252.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Related
    ENSP00000454006.1, ENST00000560361.5
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  10. NM_001384324.1 → NP_001371253.1  zinc fingers and homeoboxes protein 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS93040.1
    UniProtKB/TrEMBL
    A8K8Q0
    Related
    ENSP00000443783.2, ENST00000544979.6
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 891
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  11. NM_001384325.1 → NP_001371254.1  zinc fingers and homeoboxes protein 3 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL022394, AL031257
    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  12. NM_015035.4 → NP_055850.1  zinc fingers and homeoboxes protein 3 isoform a

    See identical proteins and their annotated locations for NP_055850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AB081948, AL022394, AL031257, BI458686
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
    UniProtKB/TrEMBL
    A8K8Q0
    Related
    ENSP00000415498.3, ENST00000432768.6
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    41178455..41317731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440045.1 → XP_047296001.1  zinc fingers and homeoboxes protein 3 isoform X3

    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2

  2. XM_005260341.5 → XP_005260398.1  zinc fingers and homeoboxes protein 3 isoform X2

    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 891
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  3. XM_047440044.1 → XP_047296000.1  zinc fingers and homeoboxes protein 3 isoform X2

  4. XM_047440046.1 → XP_047296002.1  zinc fingers and homeoboxes protein 3 isoform X3

    UniProtKB/Swiss-Prot
    E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2

  5. XM_047440036.1 → XP_047295992.1  zinc fingers and homeoboxes protein 3 isoform X1

  6. XM_047440037.1 → XP_047295993.1  zinc fingers and homeoboxes protein 3 isoform X1

  7. XM_047440039.1 → XP_047295995.1  zinc fingers and homeoboxes protein 3 isoform X1

  8. XM_011528704.4 → XP_011527006.1  zinc fingers and homeoboxes protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011527006.1

    UniProtKB/TrEMBL
    A8K8Q0
    Conserved Domains (4) summary
    smart00389
    Location:621 → 666
    HOX; Homeodomain
    cd00086
    Location:500 → 553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850 → 892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105 → 157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  9. XM_047440040.1 → XP_047295996.1  zinc fingers and homeoboxes protein 3 isoform X1

  10. XM_047440038.1 → XP_047295994.1  zinc fingers and homeoboxes protein 3 isoform X1

  11. XM_047440041.1 → XP_047295997.1  zinc fingers and homeoboxes protein 3 isoform X1

  12. XM_047440042.1 → XP_047295998.1  zinc fingers and homeoboxes protein 3 isoform X1

  13. XM_047440043.1 → XP_047295999.1  zinc fingers and homeoboxes protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    42910141..43049531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323243.1 → XP_054179218.1  zinc fingers and homeoboxes protein 3 isoform X3

  2. XM_054323241.1 → XP_054179216.1  zinc fingers and homeoboxes protein 3 isoform X2

  3. XM_054323242.1 → XP_054179217.1  zinc fingers and homeoboxes protein 3 isoform X2

  4. XM_054323244.1 → XP_054179219.1  zinc fingers and homeoboxes protein 3 isoform X3

  5. XM_054323233.1 → XP_054179208.1  zinc fingers and homeoboxes protein 3 isoform X1

  6. XM_054323234.1 → XP_054179209.1  zinc fingers and homeoboxes protein 3 isoform X1

  7. XM_054323236.1 → XP_054179211.1  zinc fingers and homeoboxes protein 3 isoform X1

  8. XM_054323232.1 → XP_054179207.1  zinc fingers and homeoboxes protein 3 isoform X1

  9. XM_054323237.1 → XP_054179212.1  zinc fingers and homeoboxes protein 3 isoform X1

  10. XM_054323235.1 → XP_054179210.1  zinc fingers and homeoboxes protein 3 isoform X1

  11. XM_054323238.1 → XP_054179213.1  zinc fingers and homeoboxes protein 3 isoform X1

  12. XM_054323239.1 → XP_054179214.1  zinc fingers and homeoboxes protein 3 isoform X1

  13. XM_054323240.1 → XP_054179215.1  zinc fingers and homeoboxes protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H4I2.3 GenPept UniProtKB/Swiss-Prot:Q9H4I2

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