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Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 [ Mus musculus (house mouse) ]

Gene ID: 230649, updated on 27-Nov-2024

Summary

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Official Symbol
Atpaf1provided by MGI
Official Full Name
ATP synthase mitochondrial F1 complex assembly factor 1provided by MGI
Primary source
MGI:MGI:2180560
See related
Ensembl:ENSMUSG00000028710 AllianceGenome:MGI:2180560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATP11; ATP11p; 6330547J17Rik
Summary
Enables protein-containing complex stabilizing activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial inner membrane. Orthologous to human ATPAF1 (ATP synthase mitochondrial F1 complex assembly factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 19.3), ovary adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atpaf1 in Genome Data Viewer
Location:
4 D1; 4 53.06 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115642025..115669120)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115784828..115811923)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene Neighboring gene EF-hand calcium binding domain 14 Neighboring gene testis expressed 38 Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene STARR-positive B cell enhancer ABC_E1650 Neighboring gene MOB kinase activator 3C Neighboring gene STARR-positive B cell enhancer ABC_E6199 Neighboring gene MAP kinase-interacting serine/threonine kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATPAF1 deficiency impairs ATP synthase assembly and mitochondrial respiration. Zhou Z, et al. Mitochondrion, 2021 Sep. PMID 34375736, Free PMC Article
  2. Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Boerries M, et al. Mol Cell Biol, 2007 Jun. PMID 17438143, Free PMC Article
  3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ca(2+)-dependent interaction of SF100A1 with Atpaf1 leads to an increased ATP content in cardiomyocytes.
    Title: Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein-containing complex stabilizing activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP synthase mitochondrial F1 complex assembly factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369233.1 → NP_001356162.1  ATP synthase mitochondrial F1 complex assembly factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626806
    Consensus CDS
    CCDS89811.1
    UniProtKB/Swiss-Prot
    Q811I0
    UniProtKB/TrEMBL
    V9GX21
    Related
    ENSMUSP00000158943.2, ENSMUST00000239030.2
    Conserved Domains (1) summary
    pfam06644
    Location:73 → 303
    ATP11; ATP11 protein

  2. NM_181040.5 → NP_851383.2  ATP synthase mitochondrial F1 complex assembly factor 1 isoform 1

    See identical proteins and their annotated locations for NP_851383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL626806
    Consensus CDS
    CCDS18496.2
    UniProtKB/TrEMBL
    H3BLL2
    Related
    ENSMUSP00000135831.2, ENSMUST00000176047.8
    Conserved Domains (1) summary
    pfam06644
    Location:97 → 329
    ATP11; ATP11 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115642025..115669120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811I0.1 GenPept UniProtKB/Swiss-Prot:Q811I0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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