Igsf21 immunoglobulin superfamily, member 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igsf21provided by MGI
Official Full Name: immunoglobulin superfamily, member 21provided by MGI
Primary source: MGI:MGI:2681842
See related: Ensembl:ENSMUSG00000040972 AllianceGenome:MGI:2681842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm141
Summary: Involved in synapse maturation and trans-synaptic signaling, modulating synaptic transmission. Located in external side of plasma membrane; inhibitory synapse; and presynaptic membrane. Is active in postsynaptic density membrane. Is expressed in several structures, including brain; ganglia; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human IGSF21 (immunoglobin superfamily member 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 14.5), frontal lobe adult (RPKM 13.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 71.09 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (139754163..139974294, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (140026852..140246983, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IgSF21 interacts with neurexin2alpha to induce presynaptic differentiation of inhibitory synapses, and mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission
Title: IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

D5Rat67 (e-PCR), detects polymorphism
- UniSTS:227962

BG381331 (e-PCR)
- UniSTS:260771

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: immunoglobulin superfamily member 21

Names: immunoglobin superfamily, member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198610.2 → NP_941012.1 immunoglobulin superfamily member 21 precursor

See identical proteins and their annotated locations for NP_941012.1

Status: VALIDATED

Source sequence(s)

BB867903, BC055811

Consensus CDS

CCDS18851.1

UniProtKB/Swiss-Prot

Q7TNR6

Related

ENSMUSP00000046558.9, ENSMUST00000039331.9

Conserved Domains (2) summary

smart00410
Location:353 → 430

IG_like; Immunoglobulin like

cl11960
Location:369 → 432

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

139754163..139974294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538799.4 → XP_006538862.1 immunoglobulin superfamily member 21 isoform X1

Conserved Domains (1) summary

cl11960
Location:175 → 235

Ig; Immunoglobulin domain