U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EPB41L3 erythrocyte membrane protein band 4.1 like 3 [ Homo sapiens (human) ]

Gene ID: 23136, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
EPB41L3provided by HGNC
Official Full Name
erythrocyte membrane protein band 4.1 like 3provided by HGNC
Primary source
HGNC:HGNC:3380
See related
Ensembl:ENSG00000082397 MIM:605331; AllianceGenome:HGNC:3380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4.1B; DAL1; DAL-1
Summary
Predicted to enable cytoskeletal protein-membrane anchor activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to axon. Located in cell-cell junction and plasma membrane. Implicated in esophagus squamous cell carcinoma. Biomarker of meningioma. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 28.0), testis (RPKM 24.6) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See EPB41L3 in Genome Data Viewer
Location:
18p11.31
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (5392386..5630663, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (5552548..5790830, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (5392385..5630662, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13056 Neighboring gene uncharacterized LOC105371970 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:5395432-5396631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:5456406-5456906 Neighboring gene uncharacterized LOC107985145 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5624822-5625323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:5629686-5630190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9263 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5678118-5678619 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:5684410-5684994 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5733383-5733915 Neighboring gene MIR3976 host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9264 Neighboring gene microRNA 3976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:5891299-5891826 Neighboring gene uncharacterized LOC121725015 Neighboring gene transmembrane protein 200C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DAL-1/4.1B contributes to epithelial-mesenchymal transition via regulation of transforming growth factor-β in lung cancer cell lines. Yu F, et al. Mol Med Rep, 2015 Oct. PMID 26300315
  2. The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China. Wang H, et al. BMC Gastroenterol, 2021 Sep 27. PMID 34579655, Free PMC Article
  3. Potential role of EPB41L3 (protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer. Bernkopf DB, et al. Expert Opin Ther Targets, 2008 Jul. PMID 18554153
  4. Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition. Yuan X, et al. Aging (Albany NY), 2020 Dec 11. PMID 33323539, Free PMC Article
  5. Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma. Nunes F, et al. Cancer Genet Cytogenet, 2005 Oct 15. PMID 16213361

See all (181) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer.
    Title: Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer.
  2. Over-expression of EPB41L3 promotes apoptosis of human cervical carcinoma cells through PI3K/AKT signaling.
    Title: Over-expression of EPB41L3 promotes apoptosis of human cervical carcinoma cells through PI3K/AKT signaling.
  3. DAL-1/4.1B promotes the uptake of exosomes in lung cancer cells via Heparan Sulfate Proteoglycan 2 (HSPG2).
    Title: DAL-1/4.1B promotes the uptake of exosomes in lung cancer cells via Heparan Sulfate Proteoglycan 2 (HSPG2).
  4. The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China.
    Title: The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China.
  5. Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition.
    Title: Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition.
  6. DNA methylation for cervical cancer screening: a training set in China.
    Title: DNA methylation for cervical cancer screening: a training set in China.
  7. Mutation and Expression of a Candidate Tumor Suppressor Gene EPB41L3 in Gastric and Colorectal Cancers.
    Title: Mutation and Expression of a Candidate Tumor Suppressor Gene EPB41L3 in Gastric and Colorectal Cancers.
  8. miR-452 promotes the development of gastric cancer via targeting EPB41L3.
    Title: miR-452 promotes the development of gastric cancer via targeting EPB41L3.
  9. 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment
    Title: 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment.
  10. Quantitative methylation results indicated that the level of methylation was significantly higher (hypermethylated) for FLT3 and EPB41L3 and significantly lower (hypomethylated) for SFN in tumour tissues as compared to the adjacent paired normal tissue.
    Title: Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated erythrocyte membrane protein band 4.1-like 3 (EPB41L3) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ37633, KIAA0987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein-membrane anchor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in myelin maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in paranodal junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to paranode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with axolemma ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in paranode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
band 4.1-like protein 3
Names
differentially expressed in adenocarcinoma of the lung protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281533.2 → NP_001268462.1  band 4.1-like protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different 5' non-coding exon, uses an alternate in-frame acceptor splice site at an internal exon, and lacks 2 exons in the 3' coding region, the latter of which causes a frame-shift compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AP005059, AP005671
    Consensus CDS
    CCDS62382.1
    UniProtKB/TrEMBL
    B3KY28
    Related
    ENSP00000441174.1, ENST00000544123.5
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:805 → 883
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  2. NM_001281534.3 → NP_001268463.1  band 4.1-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001268463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site at an internal exon, and lacks 3 non-consecutive in-frame coding exons compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1.
    Source sequence(s)
    AP005059, AP005671
    Consensus CDS
    CCDS62381.1
    UniProtKB/TrEMBL
    B3KY28
    Related
    ENSP00000442091.2, ENST00000540638.6
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:537 → 582
    SAB; SAB domain
    pfam05902
    Location:752 → 857
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 439
    FA; FERM adjacent (FA)

  3. NM_001281535.2 → NP_001268464.1  band 4.1-like protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001268464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate promoter, differs in the 5' UTR, initiates translation from an in-frame downstream start codon, uses an alternate in-frame acceptor splice site at an internal exon, and lacks 3 non-consecutive in-frame coding exons compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1. Variants 4 and 7 both encode the same isoform (4).
    Source sequence(s)
    AP001032, AP005059, AP005671
    Consensus CDS
    CCDS82236.1
    UniProtKB/TrEMBL
    A8K968, B3KY28
    Related
    ENSP00000488626.1, ENST00000545076.5
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:428 → 475
    SAB; SAB domain
    pfam05902
    Location:643 → 748
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  4. NM_001330557.2 → NP_001317486.1  band 4.1-like protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 8, encodes isoform 5.
    Source sequence(s)
    AP005059, AP005671
    Consensus CDS
    CCDS82237.1
    UniProtKB/TrEMBL
    A0A0A0MRA8, B3KY28
    Related
    ENSP00000341138.4, ENST00000342933.7
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:805 → 910
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  5. NM_001384682.1 → NP_001371611.1  band 4.1-like protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AP005059, AP005671
    Consensus CDS
    CCDS62382.1
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:805 → 883
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  6. NM_001384683.1 → NP_001371612.1  band 4.1-like protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 4, encodes isoform 4.
    Source sequence(s)
    AP001032, AP005059, AP005671
    Consensus CDS
    CCDS82236.1
    UniProtKB/TrEMBL
    A8K968, B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:428 → 475
    SAB; SAB domain
    pfam05902
    Location:643 → 748
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  7. NM_001384684.1 → NP_001371613.1  band 4.1-like protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 5, encodes isoform 5.
    Source sequence(s)
    AP005059, AP005671
    Consensus CDS
    CCDS82237.1
    UniProtKB/TrEMBL
    A0A0A0MRA8, B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:805 → 910
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  8. NM_001384685.1 → NP_001371614.1  band 4.1-like protein 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (6).
    Source sequence(s)
    AP005059, AP005671
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:735 → 783
    SAB; SAB domain
    pfam05902
    Location:992 → 1097
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  9. NM_001384686.1 → NP_001371615.1  band 4.1-like protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:537 → 584
    SAB; SAB domain
    pfam05902
    Location:793 → 898
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  10. NM_001384687.1 → NP_001371616.1  band 4.1-like protein 3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform 8.
    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:530 → 578
    SAB; SAB domain
    pfam05902
    Location:787 → 892
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  11. NM_001384688.1 → NP_001371617.1  band 4.1-like protein 3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform 8.
    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:530 → 578
    SAB; SAB domain
    pfam05902
    Location:787 → 892
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  12. NM_001384689.1 → NP_001371618.1  band 4.1-like protein 3 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform 9.
    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:805 → 883
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  13. NM_001384690.1 → NP_001371619.1  band 4.1-like protein 3 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform 9.
    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:805 → 883
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  14. NM_001384691.1 → NP_001371620.1  band 4.1-like protein 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:764 → 869
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  15. NM_001384692.1 → NP_001371621.1  band 4.1-like protein 3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:530 → 578
    SAB; SAB domain
    pfam05902
    Location:787 → 865
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  16. NM_001384693.1 → NP_001371622.1  band 4.1-like protein 3 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:537 → 584
    SAB; SAB domain
    pfam05902
    Location:756 → 861
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  17. NM_001384694.1 → NP_001371623.1  band 4.1-like protein 3 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:530 → 578
    SAB; SAB domain
    pfam05902
    Location:787 → 865
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  18. NM_001384695.1 → NP_001371624.1  band 4.1-like protein 3 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:548 → 596
    SAB; SAB domain
    pfam05902
    Location:764 → 842
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  19. NM_001384696.1 → NP_001371625.1  band 4.1-like protein 3 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:519 → 566
    SAB; SAB domain
    pfam05902
    Location:734 → 839
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  20. NM_001384697.1 → NP_001371626.1  band 4.1-like protein 3 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:537 → 584
    SAB; SAB domain
    pfam05902
    Location:752 → 830
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 441
    FA; FERM adjacent (FA)

  21. NM_001384698.1 → NP_001371627.1  band 4.1-like protein 3 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:439 → 487
    SAB; SAB domain
    pfam05902
    Location:696 → 801
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  22. NM_001384699.1 → NP_001371628.1  band 4.1-like protein 3 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:428 → 475
    SAB; SAB domain
    pfam05902
    Location:684 → 789
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  23. NM_001384700.1 → NP_001371629.1  band 4.1-like protein 3 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:421 → 469
    SAB; SAB domain
    pfam05902
    Location:678 → 783
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  24. NM_001384701.1 → NP_001371630.1  band 4.1-like protein 3 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:439 → 487
    SAB; SAB domain
    pfam05902
    Location:696 → 774
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  25. NM_001384702.1 → NP_001371631.1  band 4.1-like protein 3 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:410 → 457
    SAB; SAB domain
    pfam05902
    Location:666 → 771
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  26. NM_001384703.1 → NP_001371632.1  band 4.1-like protein 3 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:439 → 487
    SAB; SAB domain
    pfam05902
    Location:696 → 774
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  27. NM_001384704.1 → NP_001371633.1  band 4.1-like protein 3 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:439 → 487
    SAB; SAB domain
    pfam05902
    Location:655 → 760
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  28. NM_001384705.1 → NP_001371634.1  band 4.1-like protein 3 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:421 → 469
    SAB; SAB domain
    pfam05902
    Location:678 → 756
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  29. NM_001384706.1 → NP_001371635.1  band 4.1-like protein 3 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AP001032, AP005059, AP005671
    UniProtKB/TrEMBL
    B3KY28
    Conserved Domains (5) summary
    smart00295
    Location:3 → 192
    B41; Band 4.1 homologues
    cd13184
    Location:187 → 280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:421 → 469
    SAB; SAB domain
    pfam05902
    Location:637 → 742
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:289 → 332
    FA; FERM adjacent (FA)

  30. NM_012307.5 → NP_036439.2  band 4.1-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_036439.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AP005059, AP005671
    Consensus CDS
    CCDS11838.1
    UniProtKB/Swiss-Prot
    B7Z4I5, F5GX05, O95713, Q9BRP5, Q9Y2J2
    Related
    ENSP00000343158.2, ENST00000341928.7
    Conserved Domains (7) summary
    smart00295
    Location:112 → 301
    B41; Band 4.1 homologues
    cd13184
    Location:296 → 389
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:196 → 301
    FERM_M; FERM central domain
    pfam04382
    Location:717 → 763
    SAB; SAB domain
    pfam05902
    Location:974 → 1079
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:398 → 438
    FA; FERM adjacent (FA)
    pfam09379
    Location:114 → 174
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    5392386..5630663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437384.1 → XP_047293340.1  band 4.1-like protein 3 isoform X31

  2. XM_047437372.1 → XP_047293328.1  band 4.1-like protein 3 isoform X15

  3. XM_047437382.1 → XP_047293338.1  band 4.1-like protein 3 isoform X29

  4. XM_047437383.1 → XP_047293339.1  band 4.1-like protein 3 isoform X30

  5. XM_047437381.1 → XP_047293337.1  band 4.1-like protein 3 isoform X28

  6. XM_047437378.1 → XP_047293334.1  band 4.1-like protein 3 isoform X25

  7. XM_047437380.1 → XP_047293336.1  band 4.1-like protein 3 isoform X27

  8. XM_017025631.2 → XP_016881120.1  band 4.1-like protein 3 isoform X23

    UniProtKB/TrEMBL
    B3KY28

  9. XM_017025626.2 → XP_016881115.1  band 4.1-like protein 3 isoform X21

    UniProtKB/TrEMBL
    B3KY28

  10. XM_017025619.2 → XP_016881108.1  band 4.1-like protein 3 isoform X17

    UniProtKB/TrEMBL
    B3KY28

  11. XM_047437368.1 → XP_047293324.1  band 4.1-like protein 3 isoform X11

  12. XM_047437364.1 → XP_047293320.1  band 4.1-like protein 3 isoform X7

  13. XM_047437367.1 → XP_047293323.1  band 4.1-like protein 3 isoform X10

  14. XM_047437366.1 → XP_047293322.1  band 4.1-like protein 3 isoform X9

  15. XM_047437361.1 → XP_047293317.1  band 4.1-like protein 3 isoform X4

  16. XM_047437370.1 → XP_047293326.1  band 4.1-like protein 3 isoform X13

  17. XM_047437379.1 → XP_047293335.1  band 4.1-like protein 3 isoform X26

  18. XM_047437369.1 → XP_047293325.1  band 4.1-like protein 3 isoform X12

  19. XM_047437373.1 → XP_047293329.1  band 4.1-like protein 3 isoform X16

  20. XM_047437374.1 → XP_047293330.1  band 4.1-like protein 3 isoform X19

  21. XM_047437376.1 → XP_047293332.1  band 4.1-like protein 3 isoform X22

  22. XM_047437377.1 → XP_047293333.1  band 4.1-like protein 3 isoform X24

  23. XM_047437375.1 → XP_047293331.1  band 4.1-like protein 3 isoform X20

  24. XM_017025620.3 → XP_016881109.1  band 4.1-like protein 3 isoform X18

    UniProtKB/TrEMBL
    B3KY28

  25. XM_047437371.1 → XP_047293327.1  band 4.1-like protein 3 isoform X14

  26. XM_047437365.1 → XP_047293321.1  band 4.1-like protein 3 isoform X8

  27. XM_047437359.1 → XP_047293315.1  band 4.1-like protein 3 isoform X2

  28. XM_047437363.1 → XP_047293319.1  band 4.1-like protein 3 isoform X6

  29. XM_047437360.1 → XP_047293316.1  band 4.1-like protein 3 isoform X3

  30. XM_047437358.1 → XP_047293314.1  band 4.1-like protein 3 isoform X1

  31. XM_047437362.1 → XP_047293318.1  band 4.1-like protein 3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    5552548..5790830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318335.1 → XP_054174310.1  band 4.1-like protein 3 isoform X31

  2. XM_054318319.1 → XP_054174294.1  band 4.1-like protein 3 isoform X15

  3. XM_054318333.1 → XP_054174308.1  band 4.1-like protein 3 isoform X29

  4. XM_054318334.1 → XP_054174309.1  band 4.1-like protein 3 isoform X30

  5. XM_054318332.1 → XP_054174307.1  band 4.1-like protein 3 isoform X28

  6. XM_054318329.1 → XP_054174304.1  band 4.1-like protein 3 isoform X25

  7. XM_054318331.1 → XP_054174306.1  band 4.1-like protein 3 isoform X27

  8. XM_054318327.1 → XP_054174302.1  band 4.1-like protein 3 isoform X23

  9. XM_054318325.1 → XP_054174300.1  band 4.1-like protein 3 isoform X21

  10. XM_054318321.1 → XP_054174296.1  band 4.1-like protein 3 isoform X17

  11. XM_054318315.1 → XP_054174290.1  band 4.1-like protein 3 isoform X11

  12. XM_054318311.1 → XP_054174286.1  band 4.1-like protein 3 isoform X7

  13. XM_054318314.1 → XP_054174289.1  band 4.1-like protein 3 isoform X10

  14. XM_054318313.1 → XP_054174288.1  band 4.1-like protein 3 isoform X9

  15. XM_054318308.1 → XP_054174283.1  band 4.1-like protein 3 isoform X4

  16. XM_054318317.1 → XP_054174292.1  band 4.1-like protein 3 isoform X13

  17. XM_054318330.1 → XP_054174305.1  band 4.1-like protein 3 isoform X26

  18. XM_054318316.1 → XP_054174291.1  band 4.1-like protein 3 isoform X12

  19. XM_054318320.1 → XP_054174295.1  band 4.1-like protein 3 isoform X16

  20. XM_054318323.1 → XP_054174298.1  band 4.1-like protein 3 isoform X19

  21. XM_054318326.1 → XP_054174301.1  band 4.1-like protein 3 isoform X22

  22. XM_054318328.1 → XP_054174303.1  band 4.1-like protein 3 isoform X24

  23. XM_054318324.1 → XP_054174299.1  band 4.1-like protein 3 isoform X20

  24. XM_054318322.1 → XP_054174297.1  band 4.1-like protein 3 isoform X18

  25. XM_054318318.1 → XP_054174293.1  band 4.1-like protein 3 isoform X14

  26. XM_054318312.1 → XP_054174287.1  band 4.1-like protein 3 isoform X8

  27. XM_054318306.1 → XP_054174281.1  band 4.1-like protein 3 isoform X2

  28. XM_054318310.1 → XP_054174285.1  band 4.1-like protein 3 isoform X6

  29. XM_054318307.1 → XP_054174282.1  band 4.1-like protein 3 isoform X3

  30. XM_054318305.1 → XP_054174280.1  band 4.1-like protein 3 isoform X1

  31. XM_054318309.1 → XP_054174284.1  band 4.1-like protein 3 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2J2.2 GenPept UniProtKB/Swiss-Prot:Q9Y2J2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous