Fbxo21 F-box protein 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo21provided by MGI
Official Full Name: F-box protein 21provided by MGI
Primary source: MGI:MGI:1924223
See related: Ensembl:ENSMUSG00000032898 AllianceGenome:MGI:1924223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810425J22Rik
Summary: Predicted to enable DNA binding activity. Is expressed in nervous system and neural retina. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 54.7), whole brain E14.5 (RPKM 49.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 57.73 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (118114835..118148263)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (117976770..118010198)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis.
Title: Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235286

NoName (e-PCR)
- UniSTS:235290

D5Abb2e (e-PCR), detects polymorphism
- UniSTS:142503

AW558874 (e-PCR)
- UniSTS:207861

UniSTS:238074 (e-PCR)
- UniSTS:238074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to 5-fluorouracil	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: F-box only protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346588.1 → NP_001333517.1 F-box only protein 21 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.

Source sequence(s)

AK048131, AK049723, BE954194, BP754360, BY478760

Consensus CDS

CCDS84947.1

UniProtKB/TrEMBL

A0A0J9YU92

Related

ENSMUSP00000035506.8, ENSMUST00000035579.10
NM_145564.4 → NP_663539.1 F-box only protein 21 isoform 1

See identical proteins and their annotated locations for NP_663539.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK049723, BP754360

Consensus CDS

CCDS19607.1

UniProtKB/Swiss-Prot

Q8BHA5, Q8CHC6, Q8VDH1

UniProtKB/TrEMBL

A0A0J9YU92

Related

ENSMUSP00000143873.2, ENSMUST00000202447.4

Conserved Domains (3) summary

TIGR02097
Location:500 → 597

yccV; hemimethylated DNA binding domain

pfam12937
Location:30 → 78

F-box-like; F-box-like

pfam13369
Location:258 → 388

Transglut_core2; Transglutaminase-like superfamily