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Fam221a family with sequence similarity 221, member A [ Mus musculus (house mouse) ]

Gene ID: 231946, updated on 27-Nov-2024

Summary

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Official Symbol
Fam221aprovided by MGI
Official Full Name
family with sequence similarity 221, member Aprovided by MGI
Primary source
MGI:MGI:2442161
See related
Ensembl:ENSMUSG00000047115 AllianceGenome:MGI:2442161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D330028D13Rik
Summary
Orthologous to human FAM221A (family with sequence similarity 221 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 5.6), limb E14.5 (RPKM 2.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Fam221a in Genome Data Viewer
Location:
6 B2.3; 6 23.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49343855..49366839)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49366921..49389905)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126 Neighboring gene STARR-seq mESC enhancer starr_15828 Neighboring gene STARR-positive B cell enhancer ABC_E3654 Neighboring gene STARR-seq mESC enhancer starr_15829 Neighboring gene STARR-seq mESC enhancer starr_15830 Neighboring gene serine threonine kinase 31 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15831 Neighboring gene STARR-seq mESC enhancer starr_15832 Neighboring gene STARR-seq mESC enhancer starr_15833 Neighboring gene 40S ribosomal protein S6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein FAM221A
Names
uncharacterized protein C7orf46 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172216.1 → NP_001165687.1  protein FAM221A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC039996, BC055818, BY145860
    Consensus CDS
    CCDS51769.1
    UniProtKB/Swiss-Prot
    Q8C790
    Related
    ENSMUSP00000113242.2, ENSMUST00000121903.2
    Conserved Domains (1) summary
    pfam14753
    Location:20 → 214
    FAM221; Protein FAM221A/B

  2. NM_172727.3 → NP_766315.1  protein FAM221A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK052323, BC039996, BY145860
    Consensus CDS
    CCDS20126.1
    UniProtKB/Swiss-Prot
    Q7TML5, Q8C790
    Related
    ENSMUSP00000050237.9, ENSMUST00000060561.15
    Conserved Domains (1) summary
    pfam14753
    Location:20 → 214
    FAM221; Protein FAM221A/B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49343855..49366839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255330.1 → XP_030111190.1  protein FAM221A isoform X5

    Conserved Domains (1) summary
    pfam14753
    Location:49 → 243
    FAM221; Protein FAM221A/B

  2. XM_006505938.4 → XP_006506001.1  protein FAM221A isoform X1

    Conserved Domains (1) summary
    pfam14753
    Location:49 → 243
    FAM221; Protein FAM221A/B

  3. XM_036166034.1 → XP_036021927.1  protein FAM221A isoform X2

    Conserved Domains (1) summary
    pfam14753
    Location:49 → 243
    FAM221; Protein FAM221A/B

  4. XM_006505941.4 → XP_006506004.1  protein FAM221A isoform X3

    UniProtKB/Swiss-Prot
    Q7TML5, Q8C790
    Conserved Domains (1) summary
    pfam14753
    Location:20 → 214
    FAM221; Protein FAM221A/B

  5. XM_036166035.1 → XP_036021928.1  protein FAM221A isoform X6

    Conserved Domains (1) summary
    pfam14753
    Location:20 → 214
    FAM221; Protein FAM221A/B

  6. XM_006505940.4 → XP_006506003.1  protein FAM221A isoform X3

    UniProtKB/Swiss-Prot
    Q7TML5, Q8C790
    Conserved Domains (1) summary
    pfam14753
    Location:20 → 214
    FAM221; Protein FAM221A/B

  7. XM_011241294.3 → XP_011239596.1  protein FAM221A isoform X4

    Conserved Domains (1) summary
    pfam14753
    Location:20 → 214
    FAM221; Protein FAM221A/B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C790.1 GenPept UniProtKB/Swiss-Prot:Q8C790

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