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Mob1a MOB kinase activator 1A [ Mus musculus (house mouse) ]

Gene ID: 232157, updated on 27-Nov-2024

Summary

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Official Symbol
Mob1aprovided by MGI
Official Full Name
MOB kinase activator 1Aprovided by MGI
Primary source
MGI:MGI:2442631
See related
Ensembl:ENSMUSG00000043131 AllianceGenome:MGI:2442631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOB1; MOB4B; Mobk1b; Mobkl1b; 4022402H07Rik
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in hippo signaling. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus; lung; and spinal cord. Orthologous to human MOB1A (MOB kinase activator 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 24.7), bladder adult (RPKM 21.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mob1a in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83303016..83320758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83326034..83342812)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene STARR-seq mESC enhancer starr_16459 Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene STARR-positive B cell enhancer ABC_E6448 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-seq mESC enhancer starr_16463 Neighboring gene bolA family member 3 Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene microRNA 6374

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner. Kato W, et al. Genes Cells, 2019 Jul. PMID 31125466
  2. Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. Nishio M, et al. FASEB J, 2019 Apr. PMID 30640535
  3. The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Lee PC, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513747, Free PMC Article
  4. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. Nishio M, et al. J Clin Invest, 2012 Dec. PMID 23143302, Free PMC Article
  5. EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Ando T, et al. Commun Biol, 2021 Nov 1. PMID 34725466, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
    Title: EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
  2. The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
    Title: The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
  3. MOB1A/B has an essential function for intestinal epithelial homeostasis.
    Title: Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.
  4. T-cell-specific double knockout of MOB1A/B in mice reduces the number of naive T cells in both the circulation and secondary lymphoid organs, but leads to an accumulation of CD4(+) CD8(-) and CD4(-) CD8(+) single-positive cells in the thymus.
    Title: MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.
  5. MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.
    Title: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6884

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 1A
Names
MOB1, Mps One Binder kinase activator-like 1B
mob1 homolog 1B
mps one binder kinase activator-like 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418174.1 → NP_001405103.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713

  2. NM_001418175.1 → NP_001405104.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713

  3. NM_001418176.1 → NP_001405105.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713

  4. NM_001418177.1 → NP_001405106.1  MOB kinase activator 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159713

  5. NM_001418178.1 → NP_001405107.1  MOB kinase activator 1A isoform c

    Status: VALIDATED

    Source sequence(s)
    AC159713
    Related
    ENSMUSP00000039115.9, ENSMUST00000038658.15

  6. NM_001418179.1 → NP_001405108.1  MOB kinase activator 1A isoform d

    Status: VALIDATED

    Source sequence(s)
    AC159713

  7. NM_145571.3 → NP_663546.1  MOB kinase activator 1A isoform a

    See identical proteins and their annotated locations for NP_663546.1

    Status: VALIDATED

    Source sequence(s)
    AC159713
    Consensus CDS
    CCDS39533.1
    UniProtKB/Swiss-Prot
    Q3TJA6, Q8C194, Q8C1C7, Q921Y0
    UniProtKB/TrEMBL
    Q3UDM0
    Related
    ENSMUSP00000054452.5, ENSMUST00000055261.11
    Conserved Domains (1) summary
    pfam03637
    Location:33 → 204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83303016..83320758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505969.4 → XP_006506032.1  MOB kinase activator 1A isoform X1

    See identical proteins and their annotated locations for XP_006506032.1

    UniProtKB/TrEMBL
    Q3UDM0
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 203
    Mob1_phocein; Mob1/phocein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921Y0.3 GenPept UniProtKB/Swiss-Prot:Q921Y0

Gene LinkOut

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