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Ppp4r2 protein phosphatase 4, regulatory subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 232314, updated on 27-Nov-2024

Summary

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Official Symbol
Ppp4r2provided by MGI
Official Full Name
protein phosphatase 4, regulatory subunit 2provided by MGI
Primary source
MGI:MGI:3027896
See related
Ensembl:ENSMUSG00000052144 AllianceGenome:MGI:3027896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230060M08Rik
Summary
Predicted to enable protein phosphatase regulator activity and protein-macromolecule adaptor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including genitourinary system; gut; immune system; liver and biliary system; and nervous system. Orthologous to human PPP4R2 (protein phosphatase 4 regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 16.8), CNS E14 (RPKM 12.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp4r2 in Genome Data Viewer
Location:
6 D3; 6 46.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (100810596..100846891)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (100833620..100869934)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16870 Neighboring gene SHQ1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer mm9_chr6:100621045-100621346 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene glucoside xylosyltransferase 2 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1325 Neighboring gene STARR-positive B cell enhancer ABC_E2197 Neighboring gene STARR-seq mESC enhancer starr_16873 Neighboring gene STARR-seq mESC enhancer starr_16877 Neighboring gene STARR-seq mESC enhancer starr_16880 Neighboring gene transmembrane protein 258 pseudogene Neighboring gene PDZ domain containing RING finger 3 Neighboring gene predicted gene, 26911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Yoon YS, et al. Proc Natl Acad Sci U S A, 2010 Oct 12. PMID 20876121, Free PMC Article
  2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein phosphatase 4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase 4 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase 4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase 4 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418205.1 → NP_001405134.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155648

  2. NM_001418206.1 → NP_001405135.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155648

  3. NM_001418207.1 → NP_001405136.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155648

  4. NM_001418208.1 → NP_001405137.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC155648

  5. NM_001418209.1 → NP_001405138.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC155648
    Related
    ENSMUSP00000145102.2, ENSMUST00000203580.2

  6. NM_001418210.1 → NP_001405139.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC155648

  7. NM_182939.5 → NP_891984.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform a

    See identical proteins and their annotated locations for NP_891984.1

    Status: VALIDATED

    Source sequence(s)
    AC155648
    Consensus CDS
    CCDS20391.1
    UniProtKB/Swiss-Prot
    Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
    UniProtKB/TrEMBL
    A0A0R4J0U2
    Related
    ENSMUSP00000066314.5, ENSMUST00000063854.7
    Conserved Domains (1) summary
    pfam09184
    Location:6 → 258
    PPP4R2; PPP4R2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    100810596..100846891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VGB7.1 GenPept UniProtKB/Swiss-Prot:Q0VGB7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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