Caprin2 caprin family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Caprin2provided by MGI
Official Full Name: caprin family member 2provided by MGI
Primary source: MGI:MGI:2448541
See related: Ensembl:ENSMUSG00000030309 AllianceGenome:MGI:2448541
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adir; Eeg1; C1qdc1; rng140
Summary: This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.2), limb E14.5 (RPKM 2.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 78.62 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (148743990..148797756, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (148842492..148896257, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
Title: Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
functions in distinct morphological events in mammalian eye development
Title: Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
RNG140 has roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from RNG105-containing granules
Title: RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.
The authors have isolated and characterized mouse cytoplasmic activation/proliferation-associated protein-2 (Caprin2), with domains belonging to both the Caprin family and the C1q and tumour necrosis factor (TNF) super-family
Title: FGF signals induce Caprin2 expression in the vertebrate lens.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124496 (e-PCR)
- UniSTS:161318

D12S1577 (e-PCR)
- UniSTS:154256

AU048852 (e-PCR)
- UniSTS:145302

AV149826 (e-PCR)
- UniSTS:164345

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caprin-2

Names: C1q domain containing 1; C1q domain-containing protein 1; RNA granule protein 140; adiponectin r; cytoplasmic activation/proliferation-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301351.2 → NP_001288280.1 caprin-2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AC134542

UniProtKB/Swiss-Prot

Q05A80

Conserved Domains (3) summary

COG2604
Location:47 → 177

COG2604; Uncharacterized conserved protein [Function unknown]

pfam00386
Location:683 → 808

C1q; C1q domain

pfam12287
Location:317 → 614

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
NM_001411635.1 → NP_001398564.1 caprin-2 isoform 1

Status: REVIEWED

Source sequence(s)

AC134542

UniProtKB/Swiss-Prot

Q05A80, Q58E31, Q6ZPG7

UniProtKB/TrEMBL

E4NKG5
NM_001411636.1 → NP_001398565.1 caprin-2 isoform 3

Status: REVIEWED

Source sequence(s)

AC134542
NM_001411637.1 → NP_001398566.1 caprin-2 isoform 4

Status: REVIEWED

Source sequence(s)

AC134542

Related

ENSMUSP00000072165.6, ENSMUST00000072324.12
NM_001411638.1 → NP_001398567.1 caprin-2 isoform 5

Status: REVIEWED

Source sequence(s)

AC134542
NM_001411639.1 → NP_001398568.1 caprin-2 isoform 6

Status: REVIEWED

Source sequence(s)

AC134542

Related

ENSMUST00000204942.2
NM_001411640.1 → NP_001398569.1 caprin-2 isoform 6

Status: REVIEWED

Source sequence(s)

AC134542
NM_181541.5 → NP_853519.2 caprin-2 isoform 1

See identical proteins and their annotated locations for NP_853519.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AC134542

Consensus CDS

CCDS39720.1

UniProtKB/Swiss-Prot

Q05A80, Q58E31, Q6ZPG7

UniProtKB/TrEMBL

E4NKG5

Related

ENSMUSP00000107195.3, ENSMUST00000111569.9

Conserved Domains (5) summary

COG5022
Location:110 → 377

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:903 → 1028

C1q; C1q domain

pfam12287
Location:528 → 839

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam13870
Location:45 → 172

DUF4201; Domain of unknown function (DUF4201)

pfam18293
Location:119 → 234

Caprin-1_dimer; Caprin-1 dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

148743990..148797756 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507041.5 → XP_006507104.1 caprin-2 isoform X3

Conserved Domains (5) summary

COG5022
Location:110 → 367

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:893 → 1018

C1q; C1q domain

pfam12287
Location:518 → 829

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam13870
Location:45 → 172

DUF4201; Domain of unknown function (DUF4201)

pfam18293
Location:119 → 224

Caprin-1_dimer; Caprin-1 dimerization domain
XM_036166093.1 → XP_036021986.1 caprin-2 isoform X6

Conserved Domains (3) summary

pfam00386
Location:562 → 687

C1q; C1q domain

pfam12287
Location:187 → 498

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:2 → 112

Caprin-1_dimer; Caprin-1 dimerization domain
XM_006507039.5 → XP_006507102.1 caprin-2 isoform X1

See identical proteins and their annotated locations for XP_006507102.1

UniProtKB/Swiss-Prot

Q05A80, Q58E31, Q6ZPG7

UniProtKB/TrEMBL

E4NKG5

Conserved Domains (5) summary

COG5022
Location:110 → 377

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:903 → 1028

C1q; C1q domain

pfam12287
Location:528 → 839

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam13870
Location:45 → 172

DUF4201; Domain of unknown function (DUF4201)

pfam18293
Location:119 → 234

Caprin-1_dimer; Caprin-1 dimerization domain
XM_030255361.2 → XP_030111221.1 caprin-2 isoform X1

UniProtKB/Swiss-Prot

Q05A80, Q58E31, Q6ZPG7

UniProtKB/TrEMBL

E4NKG5

Conserved Domains (5) summary

COG5022
Location:110 → 377

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:903 → 1028

C1q; C1q domain

pfam12287
Location:528 → 839

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam13870
Location:45 → 172

DUF4201; Domain of unknown function (DUF4201)

pfam18293
Location:119 → 234

Caprin-1_dimer; Caprin-1 dimerization domain
XM_006507040.5 → XP_006507103.1 caprin-2 isoform X2

Conserved Domains (5) summary

COG5022
Location:110 → 377

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:902 → 1027

C1q; C1q domain

pfam12287
Location:528 → 839

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam13870
Location:45 → 172

DUF4201; Domain of unknown function (DUF4201)

pfam18293
Location:119 → 234

Caprin-1_dimer; Caprin-1 dimerization domain
XM_036166092.1 → XP_036021985.1 caprin-2 isoform X4

Conserved Domains (4) summary

COG5022
Location:3 → 255

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:781 → 906

C1q; C1q domain

pfam12287
Location:406 → 717

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:2 → 112

Caprin-1_dimer; Caprin-1 dimerization domain
XM_030255362.2 → XP_030111222.1 caprin-2 isoform X4

Conserved Domains (4) summary

COG5022
Location:3 → 255

COG5022; Myosin heavy chain [General function prediction only]

pfam00386
Location:781 → 906

C1q; C1q domain

pfam12287
Location:406 → 717

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:2 → 112

Caprin-1_dimer; Caprin-1 dimerization domain