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MCF2L MCF.2 cell line derived transforming sequence like [ Homo sapiens (human) ]

Gene ID: 23263, updated on 27-Nov-2024

Summary

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Official Symbol
MCF2Lprovided by HGNC
Official Full Name
MCF.2 cell line derived transforming sequence likeprovided by HGNC
Primary source
HGNC:HGNC:14576
See related
Ensembl:ENSG00000126217 MIM:609499; AllianceGenome:HGNC:14576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBS; OST; ARHGEF14
Summary
This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in fat (RPKM 8.1), brain (RPKM 8.0) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See MCF2L in Genome Data Viewer
Location:
13q34
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112894335..113099742)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112144372..112351082)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113623528..113754056)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 11A Neighboring gene uncharacterized LOC124903253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113430716-113431329 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113432945-113433094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113434144-113435009 Neighboring gene uncharacterized LOC124903252 Neighboring gene NANOG hESC enhancer GRCh37_chr13:113444396-113445115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113460948-113461629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113462993-113463672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113505150-113505650 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113526644-113527843 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113529546-113529735 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113533651 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113534907 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113536132 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113537448 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113539894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113540393-113540968 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113543499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113546091-113546840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113552283-113552788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113556232-113557108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113557109-113557983 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113559740-113560614 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113560615-113561488 Neighboring gene uncharacterized LOC124903214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113583655-113584497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5536 Neighboring gene Sharpr-MPRA regulatory region 2656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113607452-113608169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113610492-113611232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113611233-113611972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113611973-113612713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113615435-113616158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113617605-113618326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113622683-113623202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113632813-113633750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113635625-113636560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113639843-113640840 Neighboring gene MCF2L antisense RNA 1 Neighboring gene uncharacterized LOC107984591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113668429-113668957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113676327-113676961 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113676962-113677597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113681619-113682120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113682121-113682620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113684208-113684732 Neighboring gene Sharpr-MPRA regulatory region 5526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113695415-113696161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113704798-113705384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113744195-113744700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113746783-113747284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113747285-113747784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113750605-113751105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113783538-113784264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113784265-113784991 Neighboring gene F10 antisense RNA 1 Neighboring gene coagulation factor VII Neighboring gene coagulation factor X

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis. Kong W, et al. BMC Cancer, 2021 Sep 30. PMID 34592939, Free PMC Article
  2. The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration. Liu Z, et al. J Biol Chem, 2009 Jun 5. PMID 19366686, Free PMC Article
  3. RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity. Cheng L, et al. Mol Cell Biol, 2002 Oct. PMID 12215546, Free PMC Article
  4. Regulation of vesicle transport and cell motility by Golgi-localized Dbs. Fitzpatrick ER, et al. Small GTPases, 2014. PMID 25483302, Free PMC Article
  5. A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis. Maiwald S, et al. Eur J Hum Genet, 2016 Jan. PMID 25898923, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis.
    Title: LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis.
  2. miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis.
    Title: miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis.
  3. When compared to the gemcitabine-sensitive cells, the gemcitabine-resistant cells had a higher level of MCF2L expression, suggesting that MCF2L plays an important role in gemcitabine resistance
    Title: Establishment of a human primary pancreatic cancer mouse model to examine and investigate gemcitabine resistance.
  4. A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.
    Title: A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis.
  5. MCF2L is subject to a cis-acting eQTL in synovial membrane that correlates with the OA association signal. This signal contains several functional SNPs that could account for the susceptibility and which therefore merit further investigation
    Title: Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.
  6. In conclusion, we find that GDF5, but not COG5 or MCF2L, influence the extent of radiographic damage in knee osteoarthritis
    Title: Genetic contribution to radiographic severity in osteoarthritis of the knee.
  7. A single nucleotide polymorphism in MCF2L is associated with osteoarthritis.
    Title: A variant in MCF2L is associated with osteoarthritis.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Mutation of ARHGAP9 in patients with coronary spastic angina.
  10. the guanine nucleotide exchange factor Ost has a role in negative regulation of receptor endocytosis by the small GTPase Rac1
    Title: Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A variant in MCF2L is associated with osteoarthritis.
EBI GWAS Catalog
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12122, KIAA0362

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor DBS
Names
DBL's big sister
MCF2 transforming sequence-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112732.3 → NP_001106203.2  guanine nucleotide exchange factor DBS isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK295670, AL137002, AL356740, AW241629
    Consensus CDS
    CCDS45070.2
    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000440374.2, ENST00000535094.7
    Conserved Domains (6) summary
    cd11857
    Location:1029 → 1082
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602 → 779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322 → 509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786 → 917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:800 → 914
    PH; PH domain

  2. NM_001320815.2 → NP_001307744.1  guanine nucleotide exchange factor DBS isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AK295047, AL137002, AL162454, AW241629, DA348090, DB476653
    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1052 → 1105
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600 → 777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784 → 915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798 → 912
    PH; PH domain

  3. NM_001320816.2 → NP_001307745.1  guanine nucleotide exchange factor DBS isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (d) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AB116074, AK295047, AL137002, AW241629, DB276568
    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000397285.1, ENST00000421756.5
    Conserved Domains (6) summary
    cd11857
    Location:1033 → 1086
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606 → 783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326 → 513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790 → 921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:804 → 918
    PH; PH domain

  4. NM_001320817.2 → NP_001307746.1  guanine nucleotide exchange factor DBS isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains differences in the both UTRs and both the 5' and 3' coding regions, compared to variant 1. The resulting isoform (e) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AK295047, BC020208, DB476653
    Consensus CDS
    CCDS81782.1
    UniProtKB/TrEMBL
    A0A994J4L8
    Related
    ENSP00000364747.4, ENST00000375597.8
    Conserved Domains (4) summary
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600 → 777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784 → 915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  5. NM_001366644.2 → NP_001353573.1  guanine nucleotide exchange factor DBS isoform f

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL356740, AL596093
    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (5) summary
    cd11857
    Location:1000 → 1053
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17 → 162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573 → 750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293 → 480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757 → 888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  6. NM_001366645.2 → NP_001353574.1  guanine nucleotide exchange factor DBS isoform g

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL596093
    UniProtKB/TrEMBL
    H7C275

  7. NM_001366646.2 → NP_001353575.1  guanine nucleotide exchange factor DBS isoform h

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL596093
    UniProtKB/TrEMBL
    H7C275

  8. NM_024979.4 → NP_079255.4  guanine nucleotide exchange factor DBS isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK295047, AL137002, AL162454, AW241629, DB476653
    Consensus CDS
    CCDS9527.3
    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000364754.3, ENST00000375604.6
    Conserved Domains (6) summary
    cd11857
    Location:1027 → 1080
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600 → 777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784 → 915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798 → 912
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    112894335..113099742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537482.2 → XP_011535784.1  guanine nucleotide exchange factor DBS isoform X2

    See identical proteins and their annotated locations for XP_011535784.1

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1115 → 1168
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352 → 563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:830 → 944
    PH; PH domain

  2. XM_047430220.1 → XP_047286176.1  guanine nucleotide exchange factor DBS isoform X8

  3. XM_047430221.1 → XP_047286177.1  guanine nucleotide exchange factor DBS isoform X11

    Related
    ENSP00000364758.3, ENST00000375608.7

  4. XM_047430226.1 → XP_047286182.1  guanine nucleotide exchange factor DBS isoform X18

  5. XM_011537483.3 → XP_011535785.1  guanine nucleotide exchange factor DBS isoform X2

    See identical proteins and their annotated locations for XP_011535785.1

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1115 → 1168
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632 → 809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352 → 563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816 → 947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:830 → 944
    PH; PH domain

  6. XM_047430222.1 → XP_047286178.1  guanine nucleotide exchange factor DBS isoform X11

  7. XM_011537486.3 → XP_011535788.3  guanine nucleotide exchange factor DBS isoform X1

  8. XM_017020493.2 → XP_016875982.2  guanine nucleotide exchange factor DBS isoform X3

  9. XM_017020495.2 → XP_016875984.2  guanine nucleotide exchange factor DBS isoform X6

    Related
    ENSP00000380225.1, ENST00000397030.5

  10. XM_017020499.3 → XP_016875988.2  guanine nucleotide exchange factor DBS isoform X17

  11. XM_011537485.2 → XP_011535787.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    H0Y4M6, H7C275
    Related
    ENSP00000392953.2, ENST00000453297.6
    Conserved Domains (6) summary
    cd11857
    Location:1085 → 1138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602 → 779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322 → 509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786 → 917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:800 → 914
    PH; PH domain

  12. XM_047430223.1 → XP_047286179.1  guanine nucleotide exchange factor DBS isoform X14

    Related
    ENSP00000404422.2, ENST00000420013.6

  13. XM_011537488.2 → XP_011535790.1  guanine nucleotide exchange factor DBS isoform X10

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1067 → 1120
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:28 → 173
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:584 → 761
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:304 → 491
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:768 → 899
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:782 → 896
    PH; PH domain

  14. XM_011537490.2 → XP_011535792.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1056 → 1109
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17 → 162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573 → 750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293 → 480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757 → 888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:771 → 885
    PH; PH domain

  15. XM_011537484.2 → XP_011535786.1  guanine nucleotide exchange factor DBS isoform X5

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1089 → 1142
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606 → 783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326 → 513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790 → 921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:804 → 918
    PH; PH domain

  16. XM_017020494.2 → XP_016875983.1  guanine nucleotide exchange factor DBS isoform X4

    UniProtKB/TrEMBL
    H7C275

  17. XM_047430224.1 → XP_047286180.1  guanine nucleotide exchange factor DBS isoform X15

  18. XM_011537487.2 → XP_011535789.1  guanine nucleotide exchange factor DBS isoform X9

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1083 → 1136
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600 → 777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784 → 915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798 → 912
    PH; PH domain

  19. XM_047430225.1 → XP_047286181.1  guanine nucleotide exchange factor DBS isoform X16

  20. XM_011537491.2 → XP_011535793.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:1047 → 1100
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:62 → 153
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:564 → 741
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:284 → 471
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:748 → 879
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:762 → 876
    PH; PH domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112144372..112351082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374335.1 → XP_054230310.1  guanine nucleotide exchange factor DBS isoform X11

  2. XM_054374324.1 → XP_054230299.1  guanine nucleotide exchange factor DBS isoform X2

  3. XM_054374331.1 → XP_054230306.1  guanine nucleotide exchange factor DBS isoform X8

  4. XM_054374342.1 → XP_054230317.1  guanine nucleotide exchange factor DBS isoform X18

  5. XM_054374325.1 → XP_054230300.1  guanine nucleotide exchange factor DBS isoform X2

  6. XM_054374334.1 → XP_054230309.1  guanine nucleotide exchange factor DBS isoform X11

  7. XM_054374323.1 → XP_054230298.1  guanine nucleotide exchange factor DBS isoform X19

  8. XM_054374326.1 → XP_054230301.1  guanine nucleotide exchange factor DBS isoform X20

  9. XM_054374329.1 → XP_054230304.1  guanine nucleotide exchange factor DBS isoform X21

  10. XM_054374341.1 → XP_054230316.1  guanine nucleotide exchange factor DBS isoform X22

  11. XM_054374330.1 → XP_054230305.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    H0Y4M6

  12. XM_054374338.1 → XP_054230313.1  guanine nucleotide exchange factor DBS isoform X14

  13. XM_054374333.1 → XP_054230308.1  guanine nucleotide exchange factor DBS isoform X10

  14. XM_054374336.1 → XP_054230311.1  guanine nucleotide exchange factor DBS isoform X12

  15. XM_054374328.1 → XP_054230303.1  guanine nucleotide exchange factor DBS isoform X5

  16. XM_054374327.1 → XP_054230302.1  guanine nucleotide exchange factor DBS isoform X4

  17. XM_054374339.1 → XP_054230314.1  guanine nucleotide exchange factor DBS isoform X15

  18. XM_054374332.1 → XP_054230307.1  guanine nucleotide exchange factor DBS isoform X9

  19. XM_054374340.1 → XP_054230315.1  guanine nucleotide exchange factor DBS isoform X16

  20. XM_054374337.1 → XP_054230312.1  guanine nucleotide exchange factor DBS isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15068.2 GenPept UniProtKB/Swiss-Prot:O15068

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