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EHBP1 EH domain binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23301, updated on 27-Nov-2024

Summary

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Official Symbol
EHBP1provided by HGNC
Official Full Name
EH domain binding protein 1provided by HGNC
Primary source
HGNC:HGNC:29144
See related
Ensembl:ENSG00000115504 MIM:609922; AllianceGenome:HGNC:29144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPC12; NACSIN
Summary
This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in ovary (RPKM 15.6), fat (RPKM 14.1) and 25 other tissues See more
Orthologs
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Genomic context

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See EHBP1 in Genome Data Viewer
Location:
2p15
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (62673878..63046487)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (62680198..63053564)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (62901013..63273622)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:62804913-62806112 Neighboring gene ribosomal L24 domain containing 1 pseudogene 2 Neighboring gene phosphoserine aminotransferase 1 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:62874108-62874609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:62898481-62898982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15871 Neighboring gene Sharpr-MPRA regulatory region 1961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63062886-63063515 Neighboring gene VISTA enhancer hs690 Neighboring gene ribosomal protein S20 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15873 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63270899-63271878 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63271879-63272858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:63274968-63275716 Neighboring gene VISTA enhancer hs1066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63280773-63281719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63283391-63283950 Neighboring gene EHBP1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 3143 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 pseudogene Neighboring gene orthodenticle homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population. Beikzadeh B, et al. BMC Med Genet, 2020 Apr 15. PMID 32295536, Free PMC Article
  2. The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Rai A, et al. Nat Commun, 2020 Aug 21. PMID 32826901, Free PMC Article
  3. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Li Z, et al. Sci Adv, 2016 Dec. PMID 28028537, Free PMC Article
  4. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. Guilherme A, et al. J Biol Chem, 2004 Mar 12. PMID 14676205
  5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Gudmundsson J, et al. Nat Genet, 2008 Mar. PMID 18264098, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
    Title: The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
  2. The purpose of this study was to evaluate the association of rs16901979, rs4242382 and rs1447295 on 8q24 locus, rs2735839 (KLK3 gene) and rs721048 (EHBP1 gene) with prostate adenocarcinoma through multi-stage approach to identify the polymorphisms associated with prostate cancer and use them as screening factors
    Title: Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.
  3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.
  4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Meta-analysis of genome-wide and replication association studies on prostate cancer.
  5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Validation of genome-wide prostate cancer associations in men of African descent.
  7. EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton
    Title: EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Prostate cancer, hereditary, 12
MedGen: C2678479 OMIM: 611868 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0903

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
EH domain-binding protein 1
Names
NPF calponin-like protein
testis tissue sperm-binding protein Li 50e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016758.2 RefSeqGene

    Range
    36863..377637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142614.2 → NP_001136086.1  EH domain-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001136086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK292545, AY531390, BC067215, DB072549
    Consensus CDS
    CCDS46299.1
    UniProtKB/TrEMBL
    A0A140VK17, A8K930
    Conserved Domains (3) summary
    pfam00307
    Location:412 → 508
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1035 → 1175
    DUF3585; Protein of unknown function (DUF3585)

  2. NM_001142615.3 → NP_001136087.1  EH domain-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001136087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two in-frame exons in the coding region, compared to variant 1. This variant encodes a shorter isoform (3) than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC007098, AK292545, BC067215
    Consensus CDS
    CCDS46300.1
    UniProtKB/TrEMBL
    A8K930
    Related
    ENSP00000384143.3, ENST00000405015.7
    Conserved Domains (4) summary
    pfam00307
    Location:412 → 514
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1003 → 1139
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:239 → 348
    NPF; Rabosyn-5 repeating NPF sequence-motif

  3. NM_001142616.3 → NP_001136088.1  EH domain-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001136088.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the coding region, compared to variant 1. This variant encodes a shorter isoform (3) than isoform 1. Variants 3, 4 and 11 encode the same isoform (3).
    Source sequence(s)
    AC092567, BC067215, CA394214, HY174910
    Consensus CDS
    CCDS46300.1
    UniProtKB/TrEMBL
    A8K930
    Related
    ENSP00000403783.1, ENST00000431489.6
    Conserved Domains (4) summary
    pfam00307
    Location:412 → 514
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1003 → 1139
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:239 → 348
    NPF; Rabosyn-5 repeating NPF sequence-motif

  4. NM_001354212.1 → NP_001341141.1  EH domain-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AC092567, AY331186, AY531390, BC067215, BP361773, DA403235
    Consensus CDS
    CCDS1872.1
    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1074 → 1210
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  5. NM_001354213.1 → NP_001341142.1  EH domain-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AY331186, AY531390, BC067215, BP361773, DA403235, DB072549
    Consensus CDS
    CCDS1872.1
    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1074 → 1210
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  6. NM_001354214.1 → NP_001341143.1  EH domain-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AY331186, AY531390, BC067215, BP361773, DA403235, DB072549
    Consensus CDS
    CCDS1872.1
    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1074 → 1210
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  7. NM_001354215.1 → NP_001341144.1  EH domain-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AY331186, AY531390, BC067215, BP361773, BQ215191, DA403235, DB072549
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (3) summary
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1076 → 1204
    DUF3585; Protein of unknown function (DUF3585)
    cd21254
    Location:444 → 550
    CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

  8. NM_001354216.2 → NP_001341145.1  EH domain-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AY331186, AY531390, BC067215, BP361773, BQ215191, DA312518, DA403235
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (3) summary
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1076 → 1204
    DUF3585; Protein of unknown function (DUF3585)
    cd21254
    Location:444 → 550
    CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

  9. NM_001354217.1 → NP_001341146.1  EH domain-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AY531390, BC029477, BC067215, BP361773, DA403235, DA558402
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1038 → 1174
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  10. NM_001354218.1 → NP_001341147.1  EH domain-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BC067215, DB072549
    Consensus CDS
    CCDS46300.1
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:412 → 514
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1003 → 1139
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:239 → 348
    NPF; Rabosyn-5 repeating NPF sequence-motif

  11. NM_001354219.2 → NP_001341148.1  EH domain-binding protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC092567, BC067215, CA394214, DA555784, HY174910
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:412 → 514
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1002 → 1138
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:239 → 348
    NPF; Rabosyn-5 repeating NPF sequence-motif

  12. NM_001354220.1 → NP_001341149.1  EH domain-binding protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    BC067215, DA555784, DB072549
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:412 → 514
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1002 → 1138
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:239 → 348
    NPF; Rabosyn-5 repeating NPF sequence-motif

  13. NM_001354221.2 → NP_001341150.1  EH domain-binding protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC092567, AY331186, AY531390, BC067215, BP361773, CA394214, DA403235, HY174910
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 525
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:792 → 928
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  14. NM_001354222.2 → NP_001341151.1  EH domain-binding protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC092567, BC067215, CA394214, HY174910
    Conserved Domains (4) summary
    pfam00307
    Location:412 → 490
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:721 → 857
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:239 → 348
    NPF; Rabosyn-5 repeating NPF sequence-motif

  15. NM_015252.5 → NP_056067.2  EH domain-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056067.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AC092567, AY331186, AY531390, BC067215, BP361773, CA394214, DA403235, HY174910
    Consensus CDS
    CCDS1872.1
    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
    UniProtKB/TrEMBL
    A8K930
    Related
    ENSP00000263991.5, ENST00000263991.9
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1074 → 1210
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    62673878..63046487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443744.1 → XP_047299700.1  EH domain-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9

  2. XM_011532718.4 → XP_011531020.1  EH domain-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (2) summary
    pfam00307
    Location:327 → 423
    CH; Calponin homology (CH) domain
    pfam12130
    Location:950 → 1090
    DUF3585; Protein of unknown function (DUF3585)

  3. XM_047443745.1 → XP_047299701.1  EH domain-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9

  4. XM_047443748.1 → XP_047299704.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  5. XM_047443749.1 → XP_047299705.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17
    Related
    ENSP00000385524.1, ENST00000405289.5

  6. XM_017003650.2 → XP_016859139.1  EH domain-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1038 → 1174
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  7. XM_047443751.1 → XP_047299707.1  EH domain-binding protein 1 isoform X3

  8. XM_047443758.1 → XP_047299714.1  EH domain-binding protein 1 isoform X7

  9. XM_047443762.1 → XP_047299718.1  EH domain-binding protein 1 isoform X10

  10. XM_047443770.1 → XP_047299726.1  EH domain-binding protein 1 isoform X14

  11. XM_047443767.1 → XP_047299723.1  EH domain-binding protein 1 isoform X11

  12. XM_047443773.1 → XP_047299729.1  EH domain-binding protein 1 isoform X15

  13. XM_047443754.1 → XP_047299710.1  EH domain-binding protein 1 isoform X4

  14. XM_047443747.1 → XP_047299703.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  15. XM_047443756.1 → XP_047299712.1  EH domain-binding protein 1 isoform X6

  16. XM_047443753.1 → XP_047299709.1  EH domain-binding protein 1 isoform X3

  17. XM_047443763.1 → XP_047299719.1  EH domain-binding protein 1 isoform X10

  18. XM_011532715.4 → XP_011531017.1  EH domain-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011531017.1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1074 → 1210
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  19. XM_047443757.1 → XP_047299713.1  EH domain-binding protein 1 isoform X6

  20. XM_047443764.1 → XP_047299720.1  EH domain-binding protein 1 isoform X10

  21. XM_006711971.4 → XP_006712034.1  EH domain-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1038 → 1174
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  22. XM_011532717.3 → XP_011531019.1  EH domain-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (3) summary
    pfam00307
    Location:447 → 543
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1033 → 1173
    DUF3585; Protein of unknown function (DUF3585)

  23. XM_047443768.1 → XP_047299724.1  EH domain-binding protein 1 isoform X12

  24. XM_047443760.1 → XP_047299716.1  EH domain-binding protein 1 isoform X9

  25. XM_047443769.1 → XP_047299725.1  EH domain-binding protein 1 isoform X13

  26. XM_005264227.2 → XP_005264284.1  EH domain-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005264284.1

    UniProtKB/TrEMBL
    A0A140VK17, A8K930
    Conserved Domains (3) summary
    pfam00307
    Location:412 → 508
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1035 → 1175
    DUF3585; Protein of unknown function (DUF3585)

  27. XM_047443750.1 → XP_047299706.1  EH domain-binding protein 1 isoform X3

  28. XM_047443761.1 → XP_047299717.1  EH domain-binding protein 1 isoform X10

  29. XM_047443766.1 → XP_047299722.1  EH domain-binding protein 1 isoform X11

  30. XM_047443772.1 → XP_047299728.1  EH domain-binding protein 1 isoform X15

  31. XM_005264226.4 → XP_005264283.1  EH domain-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005264283.1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
    UniProtKB/TrEMBL
    A8K930
    Conserved Domains (4) summary
    pfam00307
    Location:447 → 549
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1074 → 1210
    DUF3585; Protein of unknown function (DUF3585)
    pfam16601
    Location:274 → 383
    NPF; Rabosyn-5 repeating NPF sequence-motif

  32. XM_047443746.1 → XP_047299702.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  33. XM_047443755.1 → XP_047299711.1  EH domain-binding protein 1 isoform X6

  34. XM_047443752.1 → XP_047299708.1  EH domain-binding protein 1 isoform X3

  35. XM_047443759.1 → XP_047299715.1  EH domain-binding protein 1 isoform X7

  36. XM_047443765.1 → XP_047299721.1  EH domain-binding protein 1 isoform X10

  37. XM_047443771.1 → XP_047299727.1  EH domain-binding protein 1 isoform X14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    62680198..63053564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341085.1 → XP_054197060.1  EH domain-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9

  2. XM_054341105.1 → XP_054197080.1  EH domain-binding protein 1 isoform X8

  3. XM_054341086.1 → XP_054197061.1  EH domain-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9

  4. XM_054341099.1 → XP_054197074.1  EH domain-binding protein 1 isoform X5

  5. XM_054341106.1 → XP_054197081.1  EH domain-binding protein 1 isoform X9

  6. XM_054341115.1 → XP_054197090.1  EH domain-binding protein 1 isoform X13

  7. XM_054341090.1 → XP_054197065.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  8. XM_054341091.1 → XP_054197066.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  9. XM_054341094.1 → XP_054197069.1  EH domain-binding protein 1 isoform X4

  10. XM_054341093.1 → XP_054197068.1  EH domain-binding protein 1 isoform X3

  11. XM_054341103.1 → XP_054197078.1  EH domain-binding protein 1 isoform X7

  12. XM_054341108.1 → XP_054197083.1  EH domain-binding protein 1 isoform X10

  13. XM_054341116.1 → XP_054197091.1  EH domain-binding protein 1 isoform X14

  14. XM_054341113.1 → XP_054197088.1  EH domain-binding protein 1 isoform X11

  15. XM_054341119.1 → XP_054197094.1  EH domain-binding protein 1 isoform X15

  16. XM_054341098.1 → XP_054197073.1  EH domain-binding protein 1 isoform X4

  17. XM_054341089.1 → XP_054197064.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  18. XM_054341101.1 → XP_054197076.1  EH domain-binding protein 1 isoform X6

  19. XM_054341097.1 → XP_054197072.1  EH domain-binding protein 1 isoform X3

  20. XM_054341109.1 → XP_054197084.1  EH domain-binding protein 1 isoform X10

  21. XM_054341084.1 → XP_054197059.1  EH domain-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9

  22. XM_054341102.1 → XP_054197077.1  EH domain-binding protein 1 isoform X6

  23. XM_054341110.1 → XP_054197085.1  EH domain-binding protein 1 isoform X10

  24. XM_054341095.1 → XP_054197070.1  EH domain-binding protein 1 isoform X4

  25. XM_054341114.1 → XP_054197089.1  EH domain-binding protein 1 isoform X12

  26. XM_054341087.1 → XP_054197062.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  27. XM_054341092.1 → XP_054197067.1  EH domain-binding protein 1 isoform X3

  28. XM_054341107.1 → XP_054197082.1  EH domain-binding protein 1 isoform X10

  29. XM_054341112.1 → XP_054197087.1  EH domain-binding protein 1 isoform X11

  30. XM_054341118.1 → XP_054197093.1  EH domain-binding protein 1 isoform X15

  31. XM_054341083.1 → XP_054197058.1  EH domain-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9

  32. XM_054341088.1 → XP_054197063.1  EH domain-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140VK17

  33. XM_054341100.1 → XP_054197075.1  EH domain-binding protein 1 isoform X6

  34. XM_054341096.1 → XP_054197071.1  EH domain-binding protein 1 isoform X3

  35. XM_054341104.1 → XP_054197079.1  EH domain-binding protein 1 isoform X7

  36. XM_054341111.1 → XP_054197086.1  EH domain-binding protein 1 isoform X10

  37. XM_054341117.1 → XP_054197092.1  EH domain-binding protein 1 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NDI1.3 GenPept UniProtKB/Swiss-Prot:Q8NDI1

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