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CLASP1 cytoplasmic linker associated protein 1 [ Homo sapiens (human) ]

Gene ID: 23332, updated on 27-Nov-2024

Summary

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Official Symbol
CLASP1provided by HGNC
Official Full Name
cytoplasmic linker associated protein 1provided by HGNC
Primary source
HGNC:HGNC:17088
See related
Ensembl:ENSG00000074054 MIM:605852; AllianceGenome:HGNC:17088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAST1
Summary
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

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See CLASP1 in Genome Data Viewer
Location:
2q14.2-q14.3
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (121337776..121649462, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (121773062..122084742, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (122095352..122407038, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121974845-121975346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:122003829-122004330 Neighboring gene transcription factor CP2 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122091915-122092848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122094177-122094762 Neighboring gene ribosomal protein S17 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122109698-122109870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16463 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122140378-122140878 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:122187059-122188258 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122205649-122205872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16465 Neighboring gene CLASP1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122405992-122406620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122406621-122407247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16469 Neighboring gene NIFK antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:122437634-122438136 Neighboring gene ribosomal protein L12 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:122457551-122458050 Neighboring gene uncharacterized LOC124906186

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment. Aonuma M, et al. Cell Struct Funct, 2005. PMID 16145243
  2. Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process. Zhao X, et al. Cell Microbiol, 2013 Apr. PMID 23107073, Free PMC Article
  3. How do kinetochores CLASP dynamic microtubules? Maiato H, et al. Cell Cycle, 2003 Nov-Dec. PMID 14504462
  4. Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells. Miller PM, et al. Nat Cell Biol, 2009 Sep. PMID 19701196, Free PMC Article
  5. PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis. Liu J, et al. J Biol Chem, 2009 Aug 21. PMID 19561070, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential regulation of single microtubules and bundles by a three-protein module.
    Title: Differential regulation of single microtubules and bundles by a three-protein module.
  2. Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions.
    Title: Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.
  3. catastrophe inhibition by SLAIN2 and CLASP1 supports mesenchymal cell shape in soft 3D matrices by enabling microtubules to perform a load-bearing function.
    Title: Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1.
  4. Acute silencing of CLASP1, a +TIP that participates in microtubule stabilization at the cell periphery, impairs trypomastigote internalization without diminishing the capacity for calcium-regulated lysosome exocytosis.
    Title: Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process.
  5. Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections.
    Title: CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.
  6. our data suggest a model for mitotic spindle positioning in which RanGTP and CLASP1 cooperate to align the spindle along the long axis of the dividing cell.
    Title: RanGTP and CLASP1 cooperate to position the mitotic spindle.
  7. findings highlight the common mechanistic use of TOG domains in XMAP215 and CLASP families to regulate MT dynamics and suggest that differential TOG domain architecture may confer distinct functions to these critical cytoskeletal regulators
    Title: A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation.
  8. The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP1, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM).
    Title: Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.
  9. Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells.
    Title: CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
  10. Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis.
    Title: MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2022-12-13)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2022-12-13)

ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33821, FLJ41222, KIAA0622, MGC131895, DKFZp686D1968, DKFZp686H2039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dystroglycan binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinetochore binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of spindle orientation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within establishment of spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle targeting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosomal corona IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore microtubule TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CLIP-associating protein 1
Names
multiple asters 1
multiple asters homolog 1
protein Orbit homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142273.2 → NP_001135745.1  CLIP-associating protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001135745.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate in-frame exons but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC132723, BE328429
    UniProtKB/TrEMBL
    F8WA11
    Related
    ENSP00000389372.3, ENST00000455322.7
    Conserved Domains (4) summary
    PHA03307
    Location:565 → 723
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

  2. NM_001142274.2 → NP_001135746.1  CLIP-associating protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001135746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate in-frame exon but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC112940, BE328429
    Consensus CDS
    CCDS92851.1
    UniProtKB/TrEMBL
    A0A8V8TQK9
    Related
    ENSP00000386442.3, ENST00000409078.8
    Conserved Domains (4) summary
    PHA03307
    Location:568 → 715
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

  3. NM_001207051.2 → NP_001193980.1  CLIP-associating protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001193980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has several differences in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC144107, BE328429
    Consensus CDS
    CCDS92854.1
    UniProtKB/TrEMBL
    F8WA11
    Related
    ENSP00000441625.1, ENST00000541377.5
    Conserved Domains (3) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  4. NM_001378003.1 → NP_001364932.1  CLIP-associating protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    UniProtKB/TrEMBL
    F8WA11
    Conserved Domains (4) summary
    PHA03307
    Location:568 → 715
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  5. NM_001378004.1 → NP_001364933.1  CLIP-associating protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    UniProtKB/TrEMBL
    F8WA11
    Conserved Domains (4) summary
    PHA03307
    Location:565 → 723
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  6. NM_001378005.1 → NP_001364934.1  CLIP-associating protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    UniProtKB/TrEMBL
    F8WA11
    Conserved Domains (3) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  7. NM_001395891.1 → NP_001382820.1  CLIP-associating protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    Consensus CDS
    CCDS92853.1
    UniProtKB/TrEMBL
    A0A8V8TLP7, A0A8V8TQK9
    Related
    ENSP00000512981.1, ENST00000696935.1
    Conserved Domains (2) summary
    PHA03307
    Location:564 → 806
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]

  8. NM_015282.3 → NP_056097.1  CLIP-associating protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF347693, AJ288057, BC032563, BE328429
    Consensus CDS
    CCDS92852.1
    UniProtKB/Swiss-Prot
    A2RU21, B7ZLX3, F5GWS0, O75118, Q2KHQ9, Q5H9P0, Q7Z460, Q8N5B8, Q9BQT5
    UniProtKB/TrEMBL
    A0A8V8TQK9
    Related
    ENSP00000263710.4, ENST00000263710.8
    Conserved Domains (3) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    121337776..121649462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443792.1 → XP_047299748.1  CLIP-associating protein 1 isoform X22

    Related
    ENSP00000515167.1, ENST00000700755.1

  2. XM_047443782.1 → XP_047299738.1  CLIP-associating protein 1 isoform X7

  3. XM_006712383.2 → XP_006712446.1  CLIP-associating protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8V8TQK9, A0A8V8TRF6
    Conserved Domains (4) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam05956
    Location:566 → 726
    APC_basic; APC basic domain
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

  4. XM_047443791.1 → XP_047299747.1  CLIP-associating protein 1 isoform X20

  5. XM_047443781.1 → XP_047299737.1  CLIP-associating protein 1 isoform X6

  6. XM_006712382.2 → XP_006712445.1  CLIP-associating protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A8V8TQK9
    Conserved Domains (4) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam05956
    Location:566 → 726
    APC_basic; APC basic domain
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

  7. XM_047443796.1 → XP_047299752.1  CLIP-associating protein 1 isoform X27

  8. XM_047443795.1 → XP_047299751.1  CLIP-associating protein 1 isoform X26

  9. XM_047443789.1 → XP_047299745.1  CLIP-associating protein 1 isoform X19

    Related
    ENSP00000515166.1, ENST00000700754.1

  10. XM_011510849.2 → XP_011509151.1  CLIP-associating protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8V8TQK9
    Conserved Domains (2) summary
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]

  11. XM_011510848.2 → XP_011509150.1  CLIP-associating protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TQK9
    Conserved Domains (2) summary
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]

  12. XM_047443786.1 → XP_047299742.1  CLIP-associating protein 1 isoform X14

  13. XM_047443788.1 → XP_047299744.1  CLIP-associating protein 1 isoform X17

  14. XM_047443778.1 → XP_047299734.1  CLIP-associating protein 1 isoform X3

  15. XM_017003673.2 → XP_016859162.1  CLIP-associating protein 1 isoform X12

    UniProtKB/TrEMBL
    F8WA11
    Conserved Domains (4) summary
    PHA03307
    Location:565 → 723
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

  16. XM_047443784.1 → XP_047299740.1  CLIP-associating protein 1 isoform X11

  17. XM_047443787.1 → XP_047299743.1  CLIP-associating protein 1 isoform X16

  18. XM_006712381.2 → XP_006712444.1  CLIP-associating protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8V8TQK9
    Conserved Domains (4) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam11179
    Location:572 → 723
    DUF2967; Protein of unknown function (DUF2967)
    pfam12348
    Location:326 → 537
    CLASP_N; CLASP N terminal

  19. XM_047443783.1 → XP_047299739.1  CLIP-associating protein 1 isoform X8

  20. XM_047443785.1 → XP_047299741.1  CLIP-associating protein 1 isoform X13

  21. XM_047443797.1 → XP_047299753.1  CLIP-associating protein 1 isoform X28

  22. XM_047443780.1 → XP_047299736.1  CLIP-associating protein 1 isoform X5

  23. XM_047443779.1 → XP_047299735.1  CLIP-associating protein 1 isoform X4

  24. XM_017003665.2 → XP_016859154.1  CLIP-associating protein 1 isoform X2

    UniProtKB/TrEMBL
    F8WA11

  25. XM_047443777.1 → XP_047299733.1  CLIP-associating protein 1 isoform X1

  26. XM_047443793.1 → XP_047299749.1  CLIP-associating protein 1 isoform X22

  27. XM_017003682.3 → XP_016859171.1  CLIP-associating protein 1 isoform X23

    UniProtKB/TrEMBL
    B7Z4E5
    Related
    ENSP00000400562.3, ENST00000452274.7
    Conserved Domains (2) summary
    pfam12348
    Location:94 → 305
    CLASP_N; CLASP N terminal
    sd00044
    Location:604 → 631
    HEAT; HEAT repeat [structural motif]

  28. XM_047443794.1 → XP_047299750.1  CLIP-associating protein 1 isoform X24

  29. XM_017003690.2 → XP_016859179.1  CLIP-associating protein 1 isoform X25

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    121773062..122084742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341142.1 → XP_054197117.1  CLIP-associating protein 1 isoform X22

  2. XM_054341130.1 → XP_054197105.1  CLIP-associating protein 1 isoform X7

  3. XM_054341141.1 → XP_054197116.1  CLIP-associating protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8V8TRF6

  4. XM_054341140.1 → XP_054197115.1  CLIP-associating protein 1 isoform X20

  5. XM_054341129.1 → XP_054197104.1  CLIP-associating protein 1 isoform X6

  6. XM_054341138.1 → XP_054197113.1  CLIP-associating protein 1 isoform X18

  7. XM_054341148.1 → XP_054197123.1  CLIP-associating protein 1 isoform X27

  8. XM_054341147.1 → XP_054197122.1  CLIP-associating protein 1 isoform X26

  9. XM_054341139.1 → XP_054197114.1  CLIP-associating protein 1 isoform X19

  10. XM_054341133.1 → XP_054197108.1  CLIP-associating protein 1 isoform X10

  11. XM_054341132.1 → XP_054197107.1  CLIP-associating protein 1 isoform X9

  12. XM_054341137.1 → XP_054197112.1  CLIP-associating protein 1 isoform X17

  13. XM_054341126.1 → XP_054197101.1  CLIP-associating protein 1 isoform X3

  14. XM_054341134.1 → XP_054197109.1  CLIP-associating protein 1 isoform X12

  15. XM_054341136.1 → XP_054197111.1  CLIP-associating protein 1 isoform X16

  16. XM_054341135.1 → XP_054197110.1  CLIP-associating protein 1 isoform X15

  17. XM_054341131.1 → XP_054197106.1  CLIP-associating protein 1 isoform X8

  18. XM_054341149.1 → XP_054197124.1  CLIP-associating protein 1 isoform X28

  19. XM_054341128.1 → XP_054197103.1  CLIP-associating protein 1 isoform X5

  20. XM_054341127.1 → XP_054197102.1  CLIP-associating protein 1 isoform X4

  21. XM_054341125.1 → XP_054197100.1  CLIP-associating protein 1 isoform X2

  22. XM_054341143.1 → XP_054197118.1  CLIP-associating protein 1 isoform X22

  23. XM_054341124.1 → XP_054197099.1  CLIP-associating protein 1 isoform X1

  24. XM_054341144.1 → XP_054197119.1  CLIP-associating protein 1 isoform X23

  25. XM_054341145.1 → XP_054197120.1  CLIP-associating protein 1 isoform X24

  26. XM_054341146.1 → XP_054197121.1  CLIP-associating protein 1 isoform X25

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z460.1 GenPept UniProtKB/Swiss-Prot:Q7Z460

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