Mogat2 monoacylglycerol O-acyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mogat2provided by MGI
Official Full Name: monoacylglycerol O-acyltransferase 2provided by MGI
Primary source: MGI:MGI:2663253
See related: Ensembl:ENSMUSG00000052396 AllianceGenome:MGI:2663253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MGAT2; Mgat1l; DGAT2L5
Summary: Enables 2-acylglycerol O-acyltransferase activity and acetyltransferase activity. Involved in triglyceride biosynthetic process. Acts upstream of or within diacylglycerol biosynthetic process and intestinal absorption. Predicted to be located in perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo endoderm; liver; metanephros; and yolk sac. Orthologous to human MOGAT2 (monoacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 179.6), large intestine adult (RPKM 123.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 54.03 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (98868291..98887818, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99219084..99238611, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet.
Title: Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet.
MGAT2 in the intestine plays an indispensable role in enhancing metabolic efficiency but also raise the possibility that MGAT2 in other tissues may contribute to the regulation of energy metabolism.
Title: Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice.
the release of gut peptides following oral triglyceride ingestion in MGAT2 and DGAT1 knock-out mice was investigated.
Title: Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion.
Mogat2 is a key determinant of energy metabolism in response to dietary fat and suggest that inhibition or deletion of this enzyme may prove to be a useful strategy for treating obesity.
Title: Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
MGAT2 possessed an intrinsic acyl-CoA:diacylglycerol acyltransferase (DGAT) activity which could provide an alternative pathway for triacylglycerol synthesis in the absence of DGAT
Title: Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2.
MGAT catalyzes the synthesis of diacylglycerol, a precursor of triacylglycerol. MGAT mediates the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes, a step required for delivering absorbed fat to other tissues.
Title: MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mogat2 (e-PCR), detects polymorphism
- UniSTS:516141

26.MMHAP94FLA5.seq (e-PCR)
- UniSTS:123762

NoName (e-PCR)
- UniSTS:235717

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-acylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-acylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-acylglycerol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within diacylglycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal absorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2-acylglycerol O-acyltransferase 2

Names: acyl CoA:monoacylglycerol acyltransferase 2; diacylglycerol acyltransferase 2-like protein 5

NP_803231.1

EC 2.3.1.20

EC 2.3.1.22

XP_011240039.1

EC 2.3.1.20

EC 2.3.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177448.4 → NP_803231.1 2-acylglycerol O-acyltransferase 2

See identical proteins and their annotated locations for NP_803231.1

Status: VALIDATED

Source sequence(s)

AK133854, BC052831

Consensus CDS

CCDS21478.1

UniProtKB/Swiss-Prot

Q80W94

Related

ENSMUSP00000064041.8, ENSMUST00000064231.8

Conserved Domains (1) summary

cl17185
Location:41 → 333

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

98868291..98887818 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241737.1 → XP_011240039.1 2-acylglycerol O-acyltransferase 2 isoform X1

Conserved Domains (1) summary

cl17185
Location:55 → 347

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis