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Ldaf1 lipid droplet assembly factor 1 [ Mus musculus (house mouse) ]

Gene ID: 233806, updated on 27-Nov-2024

Summary

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Official Symbol
Ldaf1provided by MGI
Official Full Name
lipid droplet assembly factor 1provided by MGI
Primary source
MGI:MGI:1925752
See related
Ensembl:ENSMUSG00000030917 AllianceGenome:MGI:1925752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem159; 8430420C20Rik
Summary
Predicted to be involved in lipid droplet formation. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Orthologous to human LDAF1 (lipid droplet assembly factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 36.8), adrenal adult (RPKM 35.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Ldaf1 in Genome Data Viewer
Location:
7 F2; 7 64.37 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119701599..119720212)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120102342..120120987)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 25217 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20042 Neighboring gene RIKEN cDNA 4930505K13 gene Neighboring gene STARR-seq mESC enhancer starr_20043 Neighboring gene zona pellucida glycoprotein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Yu S, et al. Biochimie, 2004 Nov. PMID 15589683
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lipid droplet assembly factor 1
Names
promethin
transmembrane protein 159

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419290.1 → NP_001406219.1  lipid droplet assembly factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122853

  2. NM_001419291.1 → NP_001406220.1  lipid droplet assembly factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122853

  3. NM_001419292.1 → NP_001406221.1  lipid droplet assembly factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122853
    UniProtKB/Swiss-Prot
    Q8C5E0, Q922Z1
    Related
    ENSMUSP00000114085.2, ENSMUST00000118737.3

  4. NM_145586.2 → NP_663561.1  lipid droplet assembly factor 1 isoform 1

    See identical proteins and their annotated locations for NP_663561.1

    Status: VALIDATED

    Source sequence(s)
    AC122853
    Consensus CDS
    CCDS21791.1
    UniProtKB/Swiss-Prot
    Q8C5E0, Q922Z1
    Related
    ENSMUSP00000033210.6, ENSMUST00000033210.13
    Conserved Domains (1) summary
    pfam16015
    Location:41 → 128
    Promethin

RNA

  1. NR_185056.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122853

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119701599..119720212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922Z1.1 GenPept UniProtKB/Swiss-Prot:Q922Z1

Gene LinkOut

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