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Slc5a11 solute carrier family 5 (sodium/glucose cotransporter), member 11 [ Mus musculus (house mouse) ]

Gene ID: 233836, updated on 27-Nov-2024

Summary

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Official Symbol
Slc5a11provided by MGI
Official Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 11provided by MGI
Primary source
MGI:MGI:1919316
See related
Ensembl:ENSMUSG00000030769 AllianceGenome:MGI:1919316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kst1; RKST2; SMIT2; Slc5a10; 2010013B02Rik
Summary
Predicted to enable D-glucose:sodium symporter activity and myo-inositol transmembrane transporter activity. Involved in regulation of transporter activity. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain; glans of male genital tubercle; and urethra. Orthologous to human SLC5A11 (solute carrier family 5 member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum adult (RPKM 46.1), small intestine adult (RPKM 29.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Slc5a11 in Genome Data Viewer
Location:
7 F3; 7 67.42 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122813817..122873612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123214594..123274388)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51498 Neighboring gene trinucleotide repeat containing 6a Neighboring gene VISTA enhancer mm1484 Neighboring gene predicted gene, 39084 Neighboring gene STARR-seq mESC enhancer starr_20085 Neighboring gene STARR-positive B cell enhancer ABC_E11366 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130281644-130281845 Neighboring gene STARR-seq mESC enhancer starr_20086 Neighboring gene STARR-seq mESC enhancer starr_20088 Neighboring gene STARR-seq mESC enhancer starr_20089 Neighboring gene STARR-seq mESC enhancer starr_20090 Neighboring gene Rho GTPase activating protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E4974 Neighboring gene STARR-seq mESC enhancer starr_20097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130521438-130521621 Neighboring gene leucine carboxyl methyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology. Fenili D, et al. PLoS One, 2011. PMID 21887366, Free PMC Article
  2. Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Fu H, et al. Neurochem Int, 2012 Jul. PMID 22564531
  3. Identification of a novel Na+/myo-inositol cotransporter. Coady MJ, et al. J Biol Chem, 2002 Sep 20. PMID 12133831
  4. KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Abbott GW, et al. Sci Signal, 2014 Mar 4. PMID 24595108, Free PMC Article
  5. Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Buccafusca R, et al. Mol Genet Metab, 2008 Sep-Oct. PMID 18675571

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification
    Title: Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH.
  2. For SMIT2, at all three ages both cortical and cerebellar SMIT2 levels were significantly higher than hippocampal levels (p<0.05) and at 4 and 6 months of age
    Title: Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
  3. Rabbit homologue acts as a low affinity Na/myo-inositol cotransporter.
    Title: Identification of a novel Na+/myo-inositol cotransporter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC25910

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myo-inositol transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables myo-inositol transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in myo-inositol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in myo-inositol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium/myo-inositol cotransporter 2
Names
Na(+)/myo-inositol cotransporter 2
na+/myo-inositol cotransporter 2
sodium-coupled cotransporter KST1
sodium-dependent glucose cotransporter
sodium/glucose cotransporter KST1
sodium/myo-inositol transporter 2
solute carrier family 5 (sodium/glucose cotransporter), member 10
solute carrier family 5 member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146198.2 → NP_666310.1  sodium/myo-inositol cotransporter 2

    See identical proteins and their annotated locations for NP_666310.1

    Status: PROVISIONAL

    Source sequence(s)
    AC138364
    Consensus CDS
    CCDS21819.1
    UniProtKB/Swiss-Prot
    Q6EZ51, Q8K0E3
    Related
    ENSMUSP00000033035.7, ENSMUST00000033035.13
    Conserved Domains (1) summary
    cl00456
    Location:28 → 673
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    122813817..122873612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241767.4 → XP_011240069.1  sodium/myo-inositol cotransporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011240069.1

    UniProtKB/Swiss-Prot
    Q6EZ51, Q8K0E3
    Conserved Domains (1) summary
    cl00456
    Location:28 → 673
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_011241766.3 → XP_011240068.1  sodium/myo-inositol cotransporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011240068.1

    UniProtKB/Swiss-Prot
    Q6EZ51, Q8K0E3
    Conserved Domains (1) summary
    cl00456
    Location:28 → 673
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_011241768.3 → XP_011240070.1  sodium/myo-inositol cotransporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011240070.1

    UniProtKB/Swiss-Prot
    Q6EZ51, Q8K0E3
    Conserved Domains (1) summary
    cl00456
    Location:28 → 673
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_006507712.4 → XP_006507775.1  sodium/myo-inositol cotransporter 2 isoform X1

    See identical proteins and their annotated locations for XP_006507775.1

    UniProtKB/Swiss-Prot
    Q6EZ51, Q8K0E3
    Related
    ENSMUSP00000127977.3, ENSMUST00000167299.9
    Conserved Domains (1) summary
    cl00456
    Location:28 → 673
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_011241769.1 → XP_011240071.1  sodium/myo-inositol cotransporter 2 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:2 → 570
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_001785540.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0E3.1 GenPept UniProtKB/Swiss-Prot:Q8K0E3

Gene LinkOut

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