Zfp809 zinc finger protein 809 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp809provided by MGI
Official Full Name: zinc finger protein 809provided by MGI
Primary source: MGI:MGI:2143362
See related: Ensembl:ENSMUSG00000057982 AllianceGenome:MGI:2143362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C330026E23
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within innate immune response and negative regulation of single stranded viral RNA replication via double stranded DNA intermediate. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 9.1), placenta adult (RPKM 4.0) and 28 other tissues See more
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Genomic context

Location:: 9 A3; 9 8.65 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (22136980..22165413)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (22225667..22254117)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that ZFP809 protein is the key mouse embryonic stem (ES) cell-specific component of the silencing complex for transcriptionally silencing of proviral DNA.
Title: Differential control of retrovirus silencing in embryonic cells by proteasomal regulation of the ZFP809 retroviral repressor.
Data suggest that interaction between KAP1 and the KRAB A box of zinc finger protein 809 (ZFP809) is critical in KAP1-dependent control of gene silencing for ZFP809 targets.
Title: Functional Domains of ZFP809 Essential for Nuclear Localization and Gene Silencing.
Furthermore, the results of the present study indicate that other zinc fingers, which were not directly involved in binding to MLV PBS, may function in potentiating binding and stable protein expression.
Title: The third to fifth zinc fingers play an essential role in the binding of ZFP809 to the MLV-derived PBS.
ZFP809 evolved to recognize foreign DNA and establish histone modification-based epigenetic silencing of endogenous retroviruses.
Title: The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses.
ZFP809 appears to be a stem-cell-specific retroviral restriction factor, and therefore may constitute a new component of the intrinsic immune system of stem cells
Title: Embryonic stem cells use ZFP809 to silence retroviral DNAs.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within innate immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 809

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164624.1 → NP_001158096.1 zinc finger protein 809 isoform 2

See identical proteins and their annotated locations for NP_001158096.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different segment for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 2.

Source sequence(s)

AK049344, BY729060, BY764604

Consensus CDS

CCDS90519.1

UniProtKB/Swiss-Prot

G3X9G7

Related

ENSMUSP00000151180.2, ENSMUST00000215618.2

Conserved Domains (6) summary

smart00349
Location:4 → 64

KRAB; krueppel associated box

COG5048
Location:125 → 348

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:215 → 235

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:4 → 43

KRAB; KRAB box

pfam13465
Location:255 → 280

zf-H2C2_2; Zinc-finger double domain
NM_172763.3 → NP_766351.3 zinc finger protein 809 isoform 1

See identical proteins and their annotated locations for NP_766351.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

BC099418, BY729060, CK389669

Consensus CDS

CCDS40560.1

UniProtKB/Swiss-Prot

G3X9G7, Q4KL58, Q8BIJ2

Related

ENSMUSP00000072286.8, ENSMUST00000072465.9

Conserved Domains (6) summary

smart00349
Location:4 → 64

KRAB; krueppel associated box

COG5048
Location:125 → 348

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:215 → 235

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:4 → 43

KRAB; KRAB box

pfam13465
Location:255 → 280

zf-H2C2_2; Zinc-finger double domain

RNA

NR_028420.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK089532, BB658893, BY729060

Related

ENSMUST00000213371.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

22136980..22165413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510188.5 → XP_006510251.1 zinc finger protein 809 isoform X1

Conserved Domains (3) summary

smart00349
Location:4 → 64

KRAB; krueppel associated box

COG5048
Location:125 → 348

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:215 → 235

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006510189.5 → XP_006510252.1 zinc finger protein 809 isoform X2

Conserved Domains (3) summary

smart00349
Location:4 → 64

KRAB; krueppel associated box

COG5048
Location:125 → 348

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:215 → 235

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_017313302.3 → XP_017168791.1 zinc finger protein 809 isoform X3

Conserved Domains (2) summary

COG5048
Location:4 → 157

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:24 → 44

ZF_C2H2; C2H2 Zn finger [structural motif]