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MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 23542, updated on 27-Nov-2024

Summary

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Official Symbol
MAPK8IP2provided by HGNC
Official Full Name
mitogen-activated protein kinase 8 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:6883
See related
Ensembl:ENSG00000008735 MIM:607755; AllianceGenome:HGNC:6883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IB2; IB-2; JIP2; PRKM8IPL
Summary
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
Expression
Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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See MAPK8IP2 in Genome Data Viewer
Location:
22q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50600793..50613978)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51111308..51124536)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51039222..51052406)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene CHKB-CPT1B readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14002 Neighboring gene choline kinase beta Neighboring gene CHKB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51039601-51040101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51047655-51048439 Neighboring gene Sharpr-MPRA regulatory region 5053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:51064758-51065540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14004 Neighboring gene arylsulfatase A Neighboring gene uncharacterized LOC124905149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51073690-51074206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51074207-51074721

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of PKM2 and MAPK8IP2 Polymorphism in Ameloblastic Carcinoma: A Retrospective Quantitative Study. Khodayari A, et al. Int J Mol Cell Med, 2012 Fall. PMID 24551779, Free PMC Article
  2. Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1. Mariño Pérez L, et al. Structure, 2024 Sep 5. PMID 39013462
  3. Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion. Aldinger KA, et al. Am J Med Genet A, 2013 Jan. PMID 23225497, Free PMC Article
  4. Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. Giza J, et al. J Neurosci, 2010 Nov 3. PMID 21048139, Free PMC Article
  5. Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. Taru H, et al. J Biol Chem, 2002 Jul 26. PMID 12023290

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1.
    Title: Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1.
  2. Human IB2 mutation has a role as a contributing genetic factor in chromosome 22-associated cognitive disorders.
    Title: Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.
  3. there is a signaling module in which IB2 scaffolds a MLK3/MKK/p38delta kinase cascade.
    Title: Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP-kinase scaffold activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables amyloid-beta binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in behavioral fear response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mating behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nonassociative learning ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal complex assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in social behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-Jun-amino-terminal kinase-interacting protein 2
Names
JNK MAP kinase scaffold protein 2
JNK MAP kinase scaffold protein JIP2
JNK-interacting protein 2
homologous to mouse JIP-1
islet-brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032955.2 RefSeqGene

    Range
    5109..18294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012324.6 → NP_036456.1  C-Jun-amino-terminal kinase-interacting protein 2

    See identical proteins and their annotated locations for NP_036456.1

    Status: REVIEWED

    Source sequence(s)
    AF136382, AI066766, AK094442, U62317
    Consensus CDS
    CCDS74886.1
    UniProtKB/Swiss-Prot
    Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4
    UniProtKB/TrEMBL
    Q86VW5
    Related
    ENSP00000330572.4, ENST00000329492.6
    Conserved Domains (2) summary
    cd11942
    Location:608 → 662
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:679 → 824
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50600793..50613978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530679.3 → XP_011528981.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    Q86VW5
    Conserved Domains (2) summary
    cd11942
    Location:609 → 663
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:680 → 825
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

  2. XM_011530680.3 → XP_011528982.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    Q86VW5
    Conserved Domains (2) summary
    cd11942
    Location:571 → 625
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:642 → 787
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

  3. XM_011530681.3 → XP_011528983.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    Q86VW5
    Conserved Domains (2) summary
    cd11942
    Location:564 → 618
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:635 → 780
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    51111308..51124536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325363.1 → XP_054181338.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

  2. XM_054325364.1 → XP_054181339.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

  3. XM_054325365.1 → XP_054181340.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016431.3: Suppressed sequence

    Description
    NM_016431.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_139124.1: Suppressed sequence

    Description
    NM_139124.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13387.2 GenPept UniProtKB/Swiss-Prot:Q13387

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