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Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Mus musculus (house mouse) ]

Gene ID: 235439, updated on 27-Nov-2024

Summary

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Official Symbol
Herc1provided by MGI
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by MGI
Primary source
MGI:MGI:2384589
See related
Ensembl:ENSMUSG00000038664 AllianceGenome:MGI:2384589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tbl; B230218H07; 2810449H11Rik; D130015N03Rik
Summary
Acts upstream of or within negative regulation of autophagy; nervous system development; and neuromuscular process controlling balance. Is expressed in several structures, including jaw bone; nervous system; sensory organ; thymus primordium; and vibrissa. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 13.0), CNS E14 (RPKM 11.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Herc1 in Genome Data Viewer
Location:
9 C; 9 35.86 cM
Exon count:
78
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66257694..66416057)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66350412..66508775)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24478 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66128344-66128644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66129452-66129653 Neighboring gene STARR-positive B cell enhancer ABC_E2899 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 39364 Neighboring gene STARR-positive B cell enhancer ABC_E6759 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66213808-66214109 Neighboring gene predicted gene, 30447 Neighboring gene predicted gene, 50499 Neighboring gene predicted gene, 23428 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66312941-66313241 Neighboring gene STARR-positive B cell enhancer ABC_E3841 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66351571-66351871 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66440763-66441064 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66444915-66445215 Neighboring gene STARR-positive B cell enhancer ABC_E2900 Neighboring gene STARR-seq mESC enhancer starr_24480 Neighboring gene STARR-positive B cell enhancer ABC_E11413 Neighboring gene carbonic anhydrase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Pedrazza L, et al. Cell Death Dis, 2023 Jan 12. PMID 36635269, Free PMC Article
  2. The HERC1 E3 Ubiquitin Ligase is essential for normal development and for neurotransmission at the mouse neuromuscular junction. Bachiller S, et al. Cell Mol Life Sci, 2015 Aug. PMID 25746226, Free PMC Article
  3. Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice. Fucà E, et al. Neurobiol Dis, 2017 Jun. PMID 28237314
  4. HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System. Bachiller S, et al. Mol Neurobiol, 2018 Dec. PMID 29603094
  5. The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses. Montes-Fernández MA, et al. Sci Rep, 2020 Jul 21. PMID 32694577, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling.
    Title: HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling.
  2. The Herc1 gene in neurobiology.
    Title: The Herc1 gene in neurobiology.
  3. The aim of the present work was to study to which extent the alteration in HERC1 may affect other cells in the nervous system and how this may influence the motor dysfunction observed in mice.
    Title: HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System.
  4. The HERC1 E3 Ubiquitin Ligase is fundamental for normal muscle function.
    Title: The HERC1 E3 Ubiquitin Ligase is essential for normal development and for neurotransmission at the mouse neuromuscular junction.
  5. The first mutation in the Herc1 gene contribute to the functional annotation of the encoded E3 ubiquitin ligase and underline the crucial and unexpected role of this protein in Purkinje cell physiology.
    Title: Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Gene trapped (1) 
  • Spontaneous (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7618

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within corpus callosum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC1
Names
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
NP_663592.3
XP_006511166.1
XP_006511167.1
XP_006511168.1
XP_006511169.1
XP_006511170.1
XP_006511171.1
XP_030100191.1
XP_030100192.1
XP_030100193.1
XP_030100194.1
XP_030100195.1
XP_036010796.1
XP_036010797.1
XP_036010798.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145617.3 → NP_663592.3  probable E3 ubiquitin-protein ligase HERC1

    Status: VALIDATED

    Source sequence(s)
    AC161382, AC166755
    Consensus CDS
    CCDS52840.1
    UniProtKB/TrEMBL
    E9PZP8
    Related
    ENSMUSP00000044801.7, ENSMUST00000042824.13
    Conserved Domains (9) summary
    smart00119
    Location:4502 → 4835
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    COG2319
    Location:3392 → 3776
    WD40; WD40 repeat [General function prediction only]
    cd00078
    Location:4471 → 4839
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2751 → 2794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    pfam00415
    Location:4098 → 4147
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:4291 → 4320
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    sd00039
    Location:3584 → 3622
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2030 → 2187
    SPRY_HERC1; SPRY domain in HERC1
    cl02567
    Location:3422 → 3773
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66257694..66416057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511103.3 → XP_006511166.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4497 → 4865
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2760 → 2803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3610 → 3648
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2039 → 2196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3448 → 3799
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006511108.3 → XP_006511171.1  probable E3 ubiquitin-protein ligase HERC1 isoform X9

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4480 → 4848
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2760 → 2803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3593 → 3631
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2039 → 2196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3431 → 3782
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006511105.3 → XP_006511168.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4490 → 4858
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2760 → 2803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3603 → 3641
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2039 → 2196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3441 → 3792
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036154904.1 → XP_036010797.1  probable E3 ubiquitin-protein ligase HERC1 isoform X10

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4473 → 4841
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2760 → 2803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3586 → 3624
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2039 → 2196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3424 → 3775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_006511106.3 → XP_006511169.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4489 → 4857
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2752 → 2795
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3602 → 3640
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2039 → 2196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3440 → 3791
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006511104.3 → XP_006511167.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4496 → 4864
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2759 → 2802
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3609 → 3647
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2038 → 2195
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3447 → 3798
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_030244331.1 → XP_030100191.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4488 → 4856
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2751 → 2794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3601 → 3639
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2038 → 2195
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3439 → 3790
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_006511107.3 → XP_006511170.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4488 → 4856
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2751 → 2794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3601 → 3639
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2030 → 2187
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3439 → 3790
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_036154903.1 → XP_036010796.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4480 → 4848
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2743 → 2786
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3593 → 3631
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2030 → 2187
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3431 → 3782
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_030244332.1 → XP_030100192.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4487 → 4855
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2750 → 2793
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3600 → 3638
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2029 → 2186
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3438 → 3789
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_036154905.1 → XP_036010798.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

    Conserved Domains (6) summary
    COG5184
    Location:2661 → 3009
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:3136 → 3504
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:1399 → 1442
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:2249 → 2287
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:678 → 835
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:2087 → 2438
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  12. XM_030244335.2 → XP_030100195.1  probable E3 ubiquitin-protein ligase HERC1 isoform X13

    Conserved Domains (6) summary
    COG5184
    Location:2660 → 3008
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:3135 → 3503
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:1398 → 1441
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:2248 → 2286
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:677 → 834
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:2086 → 2437
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  13. XM_030244334.2 → XP_030100194.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

    Conserved Domains (6) summary
    COG5184
    Location:2661 → 3009
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:3136 → 3504
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:1399 → 1442
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:2249 → 2287
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:678 → 835
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:2087 → 2438
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_030244333.1 → XP_030100193.1  probable E3 ubiquitin-protein ligase HERC1 isoform X11

    Conserved Domains (6) summary
    COG5184
    Location:2670 → 3018
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:3145 → 3513
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:1408 → 1451
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:2258 → 2296
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:687 → 844
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:2096 → 2447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001778881.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous