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Zfp280d zinc finger protein 280D [ Mus musculus (house mouse) ]

Gene ID: 235469, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp280dprovided by MGI
Official Full Name
zinc finger protein 280Dprovided by MGI
Primary source
MGI:MGI:2384583
See related
Ensembl:ENSMUSG00000038535 AllianceGenome:MGI:2384583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Suhw4; ZNF634; Znf280d; A930005F02Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in early conceptus; nervous system; olfactory epithelium; oocyte; and retina. Orthologous to human ZNF280D (zinc finger protein 280D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 9.8), CNS E14 (RPKM 9.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp280d in Genome Data Viewer
Location:
9 D; 9 40.08 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72181900..72271061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72274618..72363779)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27188 Neighboring gene STARR-seq mESC enhancer starr_24588 Neighboring gene STARR-seq mESC enhancer starr_24589 Neighboring gene STARR-seq mESC enhancer starr_24590 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72123162-72123349 Neighboring gene predicted gene, 25163 Neighboring gene STARR-seq mESC enhancer starr_24593 Neighboring gene ribosomal protein L27A pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24594 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72238180-72238457 Neighboring gene predicted gene 27230 Neighboring gene cDNA sequence BC065403 Neighboring gene STARR-positive B cell enhancer mm9_chr9:72286185-72286486 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72297295-72297404 Neighboring gene STARR-positive B cell enhancer ABC_E5084 Neighboring gene meiosis-specific nuclear structural protein 1 Neighboring gene testis expressed gene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
  2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36902

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 280D
Names
suppressor of hairy wing homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311105.1 → NP_001298034.1  zinc finger protein 280D isoform 2

    See identical proteins and their annotated locations for NP_001298034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK045173, AK146597, BB616601, BC079878, CT025608
    Consensus CDS
    CCDS81035.1
    UniProtKB/TrEMBL
    Q3TEI2, V9GXP2
    Related
    ENSMUSP00000139250.2, ENSMUST00000183410.8
    Conserved Domains (2) summary
    sd00017
    Location:372 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:57 → 241
    DUF4195; Domain of unknown function (DUF4195)

  2. NM_146224.5 → NP_666336.3  zinc finger protein 280D isoform 1

    See identical proteins and their annotated locations for NP_666336.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146597, BB616601, BC079878, CT025608
    Consensus CDS
    CCDS40683.1
    UniProtKB/Swiss-Prot
    Q3T9B1, Q68FE8, Q8BI82
    Related
    ENSMUSP00000096175.3, ENSMUST00000098576.10
    Conserved Domains (3) summary
    sd00017
    Location:372 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:335 → 369
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:57 → 241
    DUF4195; Domain of unknown function (DUF4195)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    72181900..72271061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511121.4 → XP_006511184.1  zinc finger protein 280D isoform X2

    UniProtKB/TrEMBL
    Q3TEI2
    Conserved Domains (2) summary
    sd00017
    Location:372 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:57 → 236
    DUF4195; Domain of unknown function (DUF4195)

  2. XM_006511122.3 → XP_006511185.1  zinc finger protein 280D isoform X3

    UniProtKB/TrEMBL
    Q3TEI2
    Related
    ENSMUSP00000138970.2, ENSMUST00000184517.8
    Conserved Domains (2) summary
    sd00017
    Location:372 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:57 → 236
    DUF4195; Domain of unknown function (DUF4195)

  3. XM_036154909.1 → XP_036010802.1  zinc finger protein 280D isoform X4

    Conserved Domains (1) summary
    sd00017
    Location:132 → 153
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_017313342.2 → XP_017168831.1  zinc finger protein 280D isoform X1

    UniProtKB/TrEMBL
    V9GWW1
    Related
    ENSMUSP00000138857.2, ENSMUST00000184036.8
    Conserved Domains (3) summary
    sd00017
    Location:347 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:310 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32 → 211
    DUF4195; Domain of unknown function (DUF4195)

  5. XM_017313343.2 → XP_017168832.1  zinc finger protein 280D isoform X5

    Conserved Domains (1) summary
    sd00017
    Location:102 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_030244338.1 → XP_030100198.1  zinc finger protein 280D isoform X4

    Conserved Domains (1) summary
    sd00017
    Location:132 → 153
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_004935419.1 RNA Sequence

  2. XR_004935420.1 RNA Sequence

  3. XR_004935421.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FE8.1 GenPept UniProtKB/Swiss-Prot:Q68FE8

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