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Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 [ Mus musculus (house mouse) ]

Gene ID: 235567, updated on 27-Nov-2024

Summary

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Official Symbol
Dnajc13provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C13provided by MGI
Primary source
MGI:MGI:2676368
See related
Ensembl:ENSMUSG00000032560 AllianceGenome:MGI:2676368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rme8; RME-8; Gm1124; mKIAA0678; D030002L11Rik
Summary
Predicted to be involved in endosome organization; receptor-mediated endocytosis; and regulation of intracellular transport. Predicted to be located in cytosol and early endosome membrane. Predicted to be part of WASH complex. Predicted to be active in endosome membrane. Is expressed in cerebellum and thymus primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 11.9), kidney adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc13 in Genome Data Viewer
Location:
9 F1; 9 56.61 cM
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (104028796..104140807, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104151597..104263608, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 11 Neighboring gene atypical chemokine receptor 4 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:104146526-104146727 Neighboring gene STARR-positive B cell enhancer ABC_E8310 Neighboring gene acid phosphatase 3 Neighboring gene STARR-seq mESC enhancer starr_25113 Neighboring gene predicted gene 28548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1. Follett J, et al. Neurosci Lett, 2019 Jul 27. PMID 31082451
  2. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article
  3. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
    Title: A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
  2. Dnajc13 p.Asn855Ser disrupts sorting nexin 1 membrane-tubulation and trafficking
    Title: DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0678

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of early endosome to recycling endosome transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of WASH complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 13
Names
DnaJ (Hsp40) homolog, subfamily C, member 13
j-domain containing protein, required for endocytosis
receptor mediated endocytosis RME-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163026.1 → NP_001156498.1  dnaJ homolog subfamily C member 13 isoform 2

    See identical proteins and their annotated locations for NP_001156498.1

    Status: VALIDATED

    Source sequence(s)
    AB093258, AK083408, AK165345, CD355544, CN457549, CN534380, CO045605, CV884028
    Consensus CDS
    CCDS52904.1
    UniProtKB/TrEMBL
    G3X922
    Related
    ENSMUSP00000035170.7, ENSMUST00000035170.13
    Conserved Domains (2) summary
    pfam00226
    Location:1301 → 1354
    DnaJ; DnaJ domain
    pfam14237
    Location:976 → 1020
    DUF4339; Domain of unknown function (DUF4339)

  2. NM_001359740.1 → NP_001346669.1  dnaJ homolog subfamily C member 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145736, CT030733
    Consensus CDS
    CCDS90651.1
    UniProtKB/TrEMBL
    D4AFX7
    Related
    ENSMUSP00000139804.2, ENSMUST00000186788.7
    Conserved Domains (2) summary
    pfam00226
    Location:1306 → 1359
    DnaJ; DnaJ domain
    pfam14237
    Location:981 → 1025
    DUF4339; Domain of unknown function (DUF4339)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    104028796..104140807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244342.1 → XP_030100202.1  dnaJ homolog subfamily C member 13 isoform X1

    UniProtKB/TrEMBL
    Q8CHD7
    Conserved Domains (1) summary
    pfam00226
    Location:192 → 245
    DnaJ; DnaJ domain

RNA

  1. XR_871081.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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