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Nlrp4g NLR family, pyrin domain containing 4G [ Mus musculus (house mouse) ]

Gene ID: 235779, updated on 4-Jan-2025

Summary

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Official Symbol
Nlrp4gprovided by MGI
Official Full Name
NLR family, pyrin domain containing 4Gprovided by MGI
Primary source
MGI:MGI:3700744
See related
AllianceGenome:MGI:3700744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nalp4g; Gm47180; Gm47182
Summary
Located in cytosol. Is expressed in early conceptus and ovary. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Nlrp4g in Genome Data Viewer
Location:
9; 9 F4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (124101414..124137672, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124348831..124356974)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39469 Neighboring gene RIKEN cDNA 2010315B03 gene Neighboring gene predicted gene, 20783 Neighboring gene RIKEN cDNA 4930526I15 gene Neighboring gene protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and localization of Nlrp4g in mouse preimplantation embryo. Peng H, et al. Zygote, 2015 Dec. PMID 25384339
  2. Nlrp4g is an oocyte-specific gene but is not required for oocyte maturation in the mouse. Peng H, et al. Reprod Fertil Dev, 2014 Jun. PMID 23751860
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC91128

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NLR family, pyrin domain containing 4G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004145.3 → NP_001004145.1  NLR family, pyrin domain containing 4G isoform 2

    See identical proteins and their annotated locations for NP_001004145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR, compared to variant 1. The encoded isoform (2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK136247, BC080833, CAAA01202134
    UniProtKB/TrEMBL
    Q66JP4
    Conserved Domains (2) summary
    cd08320
    Location:10 → 93
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    pfam05729
    Location:161 → 330
    NACHT; NACHT domain

  2. NM_001346422.2 → NP_001333351.2  NLR family, pyrin domain containing 4G isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CAAA01202134, CAAA01216754, LXEJ02012085
    UniProtKB/TrEMBL
    Q3UWL9
    Conserved Domains (6) summary
    cd08320
    Location:10 → 93
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:759 → 782
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:158 → 327
    NACHT; NACHT domain
    pfam17776
    Location:461 → 574
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:403 → 459
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:701 → 939
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    124101414..124137672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154927.1 → XP_036010820.1  NLR family, pyrin domain containing 4G isoform X3

    UniProtKB/TrEMBL
    Q3UWL9
    Conserved Domains (6) summary
    cd08320
    Location:10 → 92
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:692 → 715
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:148 → 317
    NACHT; NACHT domain
    pfam17776
    Location:451 → 564
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:393 → 449
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:552 → 840
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_036154926.1 → XP_036010819.1  NLR family, pyrin domain containing 4G isoform X2

    UniProtKB/TrEMBL
    Q3UWL9
    Conserved Domains (6) summary
    cd08320
    Location:10 → 92
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:692 → 720
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:148 → 317
    NACHT; NACHT domain
    pfam17776
    Location:451 → 564
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:393 → 449
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:691 → 929
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_036154925.1 → XP_036010818.1  NLR family, pyrin domain containing 4G isoform X1

    UniProtKB/TrEMBL
    Q3UWL9
    Conserved Domains (6) summary
    cd08320
    Location:10 → 93
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:702 → 730
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:158 → 327
    NACHT; NACHT domain
    pfam17776
    Location:461 → 574
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:403 → 459
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:701 → 939
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
Nucleotide Protein Strain
Heading Accession and Version

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