Mmgt1 membrane magnesium transporter 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmgt1provided by MGI
Official Full Name: membrane magnesium transporter 1provided by MGI
Primary source: MGI:MGI:2384305
See related: Ensembl:ENSMUSG00000061273 AllianceGenome:MGI:2384305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emc5; Tmem32; Mir5116; mir-5116; 9630048L06Rik
Summary: Enables cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; and magnesium ion transmembrane transporter activity. Involved in magnesium ion transport. Acts upstream of or within cobalt ion transport; copper ion transport; and iron ion transport. Located in Golgi apparatus; early endosome; and plasma membrane. Is expressed in several structures, including axial musculature; ganglia; incisor; sensory organ; and thymus primordium. Orthologous to human MMGT1 (membrane magnesium transporter 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 13.0), CNS E18 (RPKM 12.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A5; X 30.06 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (55630872..55643304, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (56585512..56597944, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These experiments suggest that MMgT proteins may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells.(MMgT1 PROTEIN, MOUSE)
Title: Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:238028

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cobalt ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables inorganic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion transmembrane transporter activity	TAS Traceable Author Statement more info
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cobalt ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within copper ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in magnesium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within magnesium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in magnesium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	ISO Inferred from Sequence Orthology more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ER membrane protein complex subunit 5

Names: transmembrane protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.