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Tmem185a transmembrane protein 185A [ Mus musculus (house mouse) ]

Gene ID: 236848, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem185aprovided by MGI
Official Full Name
transmembrane protein 185Aprovided by MGI
Primary source
MGI:MGI:2448555
See related
Ensembl:ENSMUSG00000073139 AllianceGenome:MGI:2448555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ee3
Summary
Located in dendrite. Orthologous to human TMEM185A (transmembrane protein 185A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.8), bladder adult (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem185a in Genome Data Viewer
Location:
X A7.2; X 36.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (69503359..69520796, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (70459753..70477180, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene melanoma antigen, family A, 4 pseudogene Neighboring gene predicted gene 14721 Neighboring gene STARR-seq mESC enhancer starr_47317 Neighboring gene predicted gene 14727 Neighboring gene melanoma antigen, family A, 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. Maurer MH, et al. J Neurochem, 2004 Nov. PMID 15525354
  2. A major X-linked locus affects kidney function in mice. Leduc MS, et al. Mol Genet Genomics, 2012 Dec. PMID 23011808, Free PMC Article
  3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mouse ee3 is an orphan G-protein-coupled receptor with potential connections to erythropoietin and 5HT2a receptor signalling. ee3_2, a similar gene, is also described, along with human orthologs.
    Title: Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 185A
Names
erythropoietin-induced EST 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033328.3 → NP_001028500.1  transmembrane protein 185A isoform 2

    See identical proteins and their annotated locations for NP_001028500.1

    Status: VALIDATED

    Source sequence(s)
    AK158294, AL672026
    Consensus CDS
    CCDS30176.1
    UniProtKB/TrEMBL
    Q3TYW3
    Related
    ENSMUSP00000099043.4, ENSMUST00000101506.10
    Conserved Domains (1) summary
    pfam10269
    Location:31 → 225
    Tmemb_185A; Transmembrane Fragile-X-F protein

  2. NM_001357750.1 → NP_001344679.1  transmembrane protein 185A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672026, BC145368
    Consensus CDS
    CCDS90721.1
    UniProtKB/Swiss-Prot
    A2AF53
    Related
    ENSMUSP00000110277.3, ENSMUST00000114630.3
    Conserved Domains (1) summary
    pfam10269
    Location:31 → 253
    Tmemb_185A; Transmembrane Fragile-X-F protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    69503359..69520796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318471.3 → XP_017173960.1  transmembrane protein 185A isoform X1

    Conserved Domains (1) summary
    pfam10269
    Location:4 → 170
    Tmemb_185A; Transmembrane Fragile-X-F protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AF53.1 GenPept UniProtKB/Swiss-Prot:A2AF53

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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