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Gpr75 G protein-coupled receptor 75 [ Mus musculus (house mouse) ]

Gene ID: 237716, updated on 27-Nov-2024

Summary

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Official Symbol
Gpr75provided by MGI
Official Full Name
G protein-coupled receptor 75provided by MGI
Primary source
MGI:MGI:2441843
See related
Ensembl:ENSMUSG00000043999 AllianceGenome:MGI:2441843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables C-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; liver; metanephros; skeletal muscle; and spleen. Orthologous to human GPR75 (G protein-coupled receptor 75). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 2.1), frontal lobe adult (RPKM 1.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr75 in Genome Data Viewer
Location:
11 A4; 11 18.16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30834636..30846090)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30884633..30896090)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29068 Neighboring gene predicted gene 12100 Neighboring gene STARR-seq mESC enhancer starr_29070 Neighboring gene proteasome (prosome, macropain) activator subunit 4 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC, cation transport regulator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation. Leeson-Payne A, et al. Cell Metab, 2024 May 7. PMID 38653246
  2. Gpr75 knockout mice display age-dependent cone photoreceptor cell loss. Vasudevan S, et al. J Neurochem, 2023 Nov. PMID 37840219, Free PMC Article
  3. Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension. D'Addario CA, et al. Vascul Pharmacol, 2023 Dec. PMID 37742819,
  4. Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. Speidell A, et al. J Neurochem, 2023 Jun. PMID 36978267, Free PMC Article
  5. Gpr75-deficient mice are protected from high-fat diet-induced obesity. Hossain S, et al. Obesity (Silver Spring), 2023 Apr. PMID 36854900, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR75 is a ciliary protein expressed in the brain and plays an important role in regulating food intake.
    Title: Central regulation of feeding and body weight by ciliary GPR75.
  2. Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation.
    Title: Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation.
  3. Gpr75 knockout mice display age-dependent cone photoreceptor cell loss.
    Title: Gpr75 knockout mice display age-dependent cone photoreceptor cell loss.
  4. Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.
    Title: Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.
  5. Gpr75-deficient mice are protected from high-fat diet-induced obesity.
    Title: Gpr75-deficient mice are protected from high-fat diet-induced obesity.
  6. Although CCL5 is implicated in the pathogenesis of diabetes through activation of CCRs, it has beneficial effects on beta cells through GPR75 activation.
    Title: The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8)  1 citation
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
probable G-protein coupled receptor 75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175490.4 → NP_780699.2  probable G-protein coupled receptor 75

    See identical proteins and their annotated locations for NP_780699.2

    Status: VALIDATED

    Source sequence(s)
    AK141614, BQ175263
    Consensus CDS
    CCDS24508.1
    UniProtKB/Swiss-Prot
    Q3URC1, Q6X632, Q8BXP3
    UniProtKB/TrEMBL
    Q059L0
    Related
    ENSMUSP00000105057.2, ENSMUST00000109430.2
    Conserved Domains (1) summary
    cd15007
    Location:44 → 387
    7tmA_GPR75; G protein-coupled receptor 75, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    30834636..30846090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514696.5 → XP_006514759.1  probable G-protein coupled receptor 75 isoform X1

    See identical proteins and their annotated locations for XP_006514759.1

    UniProtKB/Swiss-Prot
    Q3URC1, Q6X632, Q8BXP3
    UniProtKB/TrEMBL
    Q059L0
    Conserved Domains (1) summary
    cd15007
    Location:44 → 387
    7tmA_GPR75; G protein-coupled receptor 75, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6X632.1 GenPept UniProtKB/Swiss-Prot:Q6X632

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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