Oxgr1 oxoglutarate (alpha-ketoglutarate) receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxgr1provided by MGI
Official Full Name: oxoglutarate (alpha-ketoglutarate) receptor 1provided by MGI
Primary source: MGI:MGI:2685145
See related: Ensembl:ENSMUSG00000044819 AllianceGenome:MGI:2685145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm299; Gpr80; Gpr99; P2Y15; Cysltr3
Summary: Predicted to enable AMP binding activity; G protein-coupled adenosine receptor activity; and purine nucleoside binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in epididymis; metanephros; neural retina; and retina. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human OXGR1 (oxoglutarate receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward kidney adult (RPKM 6.8) See more
Orthologs: human all
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Genomic context

Location:: 14 E4; 14 63.63 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (120256997..120279847, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (120019585..120042435, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise-induced alpha-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.
Title: Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.
GPR91 and GPR99 are expressed on axons of developing retinal ganglion cells (RGCs) and have complementary roles during RGC axon growth in an extracellular signal-regulated kinases 1 and 2 (ERK1/2)-dependent manner. However, they have no effects on axon guidance.
Title: Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth.
study has identified OXGR1 as a novel regulator of pathological hypertrophy via the regulation of the STAT3.
Title: The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.
Title: Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.
P2Y15 is a cell surface receptor for AMP and adenosine
Title: Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492880

Oxgr1 (e-PCR), detects polymorphism
- UniSTS:527470

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables purine nucleoside binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2-oxoglutarate receptor 1

Names: G protein-coupled receptor 80; G protein-coupled receptor 99; alpha-ketoglutarate receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.