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Mgll monoglyceride lipase [ Mus musculus (house mouse) ]

Gene ID: 23945, updated on 27-Nov-2024

Summary

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Official Symbol
Mgllprovided by MGI
Official Full Name
monoglyceride lipaseprovided by MGI
Primary source
MGI:MGI:1346042
See related
Ensembl:ENSMUSG00000033174 AllianceGenome:MGI:1346042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgl; Magl
Summary
This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 221.3), genital fat pad adult (RPKM 144.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Mgll in Genome Data Viewer
Location:
6 D1; 6 39.51 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88701397..88805342)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88724412..88828360)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit alpha 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 12 Neighboring gene STARR-seq mESC enhancer starr_16585 Neighboring gene predicted gene, 26588 Neighboring gene STARR-positive B cell enhancer ABC_E10390 Neighboring gene predicted gene 15612 Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene podocalyxin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. Kienzl M, et al. Oncoimmunology, 2021. PMID 34527428, Free PMC Article
  2. Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord. Horváth E, et al. Eur J Neurosci, 2014 Feb. PMID 24494682, Free PMC Article
  3. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Petrenko AB, et al. Behav Brain Res, 2014 Sep 1. PMID 24906199
  4. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Martínez-Torres S, et al. Brain Behav Immun, 2019 Oct. PMID 31251974
  5. Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Chen R, et al. Cell Rep, 2012 Nov 29. PMID 23122958, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity.
    Title: MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity.
  2. Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.
    Title: Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.
  3. MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.
    Title: MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.
  4. Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
    Title: Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
  5. The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model.
    Title: The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model.
  6. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
    Title: Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
  7. Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
    Title: Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
  8. Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota.
    Title: Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota.
  9. Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
    Title: Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
  10. Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.
    Title: Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoacylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoacylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acylglycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in arachidonate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoacylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocannabinoid signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in varicosity IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
monoglyceride lipase
Names
monoacylglycerol lipase
NP_001159721.1
NP_001159722.1
NP_001159723.1
NP_001397462.1
NP_001397463.1
NP_001397464.1
NP_001397465.1
NP_001397466.1
NP_035974.1
XP_036021993.1
XP_036021995.1
XP_036021996.1
XP_036021997.1
XP_036021998.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166249.2 → NP_001159721.1  monoglyceride lipase isoform c

    See identical proteins and their annotated locations for NP_001159721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC153860, AC153923
    Consensus CDS
    CCDS51844.1
    UniProtKB/TrEMBL
    Q3UFN1
    Related
    ENSMUSP00000109212.2, ENSMUST00000113582.8
    Conserved Domains (2) summary
    pfam12146
    Location:41 → 230
    Hydrolase_4; Serine aminopeptidase, S33
    cl21494
    Location:22 → 249
    Abhydrolase; alpha/beta hydrolases

  2. NM_001166250.2 → NP_001159722.1  monoglyceride lipase isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (d), which does not have in vivo support, has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC153860
    UniProtKB/Swiss-Prot
    O35678
    Conserved Domains (1) summary
    cl21494
    Location:38 → 93
    Abhydrolase; alpha/beta hydrolases

  3. NM_001166251.2 → NP_001159723.1  monoglyceride lipase isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC153860, AC153923
    Consensus CDS
    CCDS51843.1
    UniProtKB/TrEMBL
    E9Q3B9, Q3UFX6
    Related
    ENSMUSP00000127374.2, ENSMUST00000163271.8
    Conserved Domains (2) summary
    pfam12146
    Location:57 → 291
    Hydrolase_4; Serine aminopeptidase, S33
    cl21494
    Location:38 → 310
    Abhydrolase; alpha/beta hydrolases

  4. NM_001410533.1 → NP_001397462.1  monoglyceride lipase isoform e

    Status: REVIEWED

    Source sequence(s)
    AC153860, AC153923
    UniProtKB/TrEMBL
    D3YYS6
    Related
    ENSMUSP00000109211.2, ENSMUST00000113581.8

  5. NM_001410534.1 → NP_001397463.1  monoglyceride lipase isoform f

    Status: REVIEWED

    Source sequence(s)
    AC153860, AC153923

  6. NM_001410535.1 → NP_001397464.1  monoglyceride lipase isoform g

    Status: REVIEWED

    Source sequence(s)
    AC153860, AC153923

  7. NM_001410536.1 → NP_001397465.1  monoglyceride lipase isoform h

    Status: REVIEWED

    Source sequence(s)
    AC153860, AC153923

  8. NM_001410537.1 → NP_001397466.1  monoglyceride lipase isoform i

    Status: REVIEWED

    Source sequence(s)
    AC153860
    Related
    ENSMUSP00000145068.2, ENSMUST00000150180.4

  9. NM_011844.5 → NP_035974.1  monoglyceride lipase isoform b

    See identical proteins and their annotated locations for NP_035974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC153860, AC153923
    Consensus CDS
    CCDS20338.1
    UniProtKB/Swiss-Prot
    O35678, Q3V2R0, Q9D9G8
    UniProtKB/TrEMBL
    Q3UFX6
    Related
    ENSMUSP00000109215.3, ENSMUST00000113585.9
    Conserved Domains (2) summary
    pfam12146
    Location:41 → 275
    Hydrolase_4; Serine aminopeptidase, S33
    cl21494
    Location:22 → 294
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88701397..88805342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166100.1 → XP_036021993.1  monoglyceride lipase isoform X1

    UniProtKB/TrEMBL
    Q3UFX6
    Conserved Domains (1) summary
    cl21494
    Location:38 → 338
    Abhydrolase; alpha/beta hydrolases

  2. XM_036166104.1 → XP_036021997.1  monoglyceride lipase isoform X5

    Conserved Domains (1) summary
    cl21494
    Location:10 → 262
    Abhydrolase; alpha/beta hydrolases

  3. XM_036166103.1 → XP_036021996.1  monoglyceride lipase isoform X4

    Conserved Domains (1) summary
    cl21494
    Location:10 → 290
    Abhydrolase; alpha/beta hydrolases

  4. XM_036166105.1 → XP_036021998.1  monoglyceride lipase isoform X6

    Conserved Domains (1) summary
    cl21494
    Location:2 → 231
    Abhydrolase; alpha/beta hydrolases

  5. XM_036166102.1 → XP_036021995.1  monoglyceride lipase isoform X3

    Conserved Domains (1) summary
    cl21494
    Location:13 → 293
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35678.1 GenPept UniProtKB/Swiss-Prot:O35678

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