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Krt90 keratin 90 [ Mus musculus (house mouse) ]

Gene ID: 239673, updated on 9-Dec-2024

Summary

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Official Symbol
Krt90provided by MGI
Official Full Name
keratin 90provided by MGI
Primary source
MGI:MGI:3045312
See related
Ensembl:ENSMUSG00000048699 AllianceGenome:MGI:3045312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ket90; 4732456N10Rik
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Orthologous to human KRT90P (keratin 90, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Krt90 in Genome Data Viewer
Location:
15 F2; 15 56.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101460791..101471385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101552356..101562950, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39799 Neighboring gene keratin 84 Neighboring gene keratin 82 Neighboring gene keratin 75 Neighboring gene STARR-seq mESC enhancer starr_39800 Neighboring gene type II keratin Kb17P pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. Sundberg JP, et al. PLoS One, 2022. PMID 36374931, Free PMC Article
  2. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741
  3. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
  4. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Titz B, et al. Oncogene, 2010 Nov 4. PMID 20697350, Free PMC Article
  5. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC239673

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177717.4 → NP_808385.2  uncharacterized protein LOC239673

    Status: VALIDATED

    Source sequence(s)
    AC103674, AK028791
    Consensus CDS
    CCDS27855.1
    UniProtKB/TrEMBL
    E9Q1Z0, Q148Q7
    Related
    ENSMUSP00000023714.5, ENSMUST00000023714.5
    Conserved Domains (4) summary
    pfam00038
    Location:142 → 453
    Filament; Intermediate filament protein
    pfam16208
    Location:16 → 139
    Keratin_2_head; Keratin type II head
    cl01888
    Location:366 → 426
    DUF883; Bacterial protein of unknown function (DUF883)
    cl14813
    Location:214 → 291
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101460791..101471385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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