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Mettl22 methyltransferase 22, Kin17 lysine [ Mus musculus (house mouse) ]

Gene ID: 239706, updated on 27-Nov-2024

Summary

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Official Symbol
Mettl22provided by MGI
Official Full Name
methyltransferase 22, Kin17 lysineprovided by MGI
Primary source
MGI:MGI:2384301
See related
Ensembl:ENSMUSG00000039345 AllianceGenome:MGI:2384301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable heat shock protein binding activity and protein methyltransferase activity. Predicted to be involved in protein methylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human METTL22 (methyltransferase 22, Kin17 lysine). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 31.3), CNS E18 (RPKM 14.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl22 in Genome Data Viewer
Location:
16 A1; 16 3.97 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8288623..8308069)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8470757..8490205)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8406840-8407023 Neighboring gene STARR-positive B cell enhancer ABC_E8615 Neighboring gene predicted gene, 24579 Neighboring gene transmembrane protein 114 Neighboring gene predicted gene, 30012 Neighboring gene predicted gene, 23706 Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene STARR-seq mESC enhancer starr_40005 Neighboring gene zinc finger, MYND domain containing 19 pseudogene Neighboring gene ferritin light chain 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC38788

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methyltransferase-like protein 22
Names
methyltransferase like 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417199.1 → NP_001404128.1  methyltransferase-like protein 22 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123851

  2. NM_001417200.1 → NP_001404129.1  methyltransferase-like protein 22 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123851

  3. NM_001417203.1 → NP_001404132.1  methyltransferase-like protein 22 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123851

  4. NM_001417204.1 → NP_001404133.1  methyltransferase-like protein 22 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123851

  5. NM_001417205.1 → NP_001404134.1  methyltransferase-like protein 22 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123851

  6. NM_001417206.1 → NP_001404135.1  methyltransferase-like protein 22 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123851

  7. NM_146247.2 → NP_666359.1  methyltransferase-like protein 22 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123851
    Consensus CDS
    CCDS27938.1
    UniProtKB/Swiss-Prot
    Q3UW48, Q8R1C6
    Related
    ENSMUSP00000044108.10, ENSMUST00000046470.16
    Conserved Domains (1) summary
    cl17173
    Location:169 → 326
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_184430.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123851

  2. NR_184431.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123851

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    8288623..8308069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522107.5 → XP_006522170.1  methyltransferase-like protein 22 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:86 → 243
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1C6.1 GenPept UniProtKB/Swiss-Prot:Q8R1C6

Gene LinkOut

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