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Pebp1 phosphatidylethanolamine binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23980, updated on 27-Nov-2024

Summary

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Official Symbol
Pebp1provided by MGI
Official Full Name
phosphatidylethanolamine binding protein 1provided by MGI
Primary source
MGI:MGI:1344408
See related
Ensembl:ENSMUSG00000032959 AllianceGenome:MGI:1344408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pbp; HCNP; Pbp1; Pbpr; Rkip
Summary
Predicted to enable ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Acts upstream of or within sperm capacitation. Located in cell surface. Is expressed in cerebral cortex ventricular layer; cortical plate; embryo; ovary; and primary sex cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 1168.4), adrenal adult (RPKM 808.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pebp1 in Genome Data Viewer
Location:
5 F; 5 56.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117420716..117425629, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117282651..117287564, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene TAO kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene predicted gene 3786 Neighboring gene cDNA sequence BC051077 Neighboring gene predicted gene, 52828

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein. Chen Y, et al. J Proteome Res, 2011 Jan 7. PMID 21155602
  2. Raf-kinase inhibitor protein attenuates microglia inflammation in an in vitro model of intracerebral hemorrhage. Wang J, et al. Cell Mol Biol (Noisy-le-grand), 2016 May 30. PMID 27262809
  3. Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush. Wei J, et al. J Mol Neurosci, 2015 Oct. PMID 26160696
  4. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. Huang Q, et al. Int Immunopharmacol, 2017 Jan. PMID 27912149
  5. Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer. Escara-Wilke J, et al. Prostate, 2015 Feb 15. PMID 25327941

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway.
    Title: AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway.
  2. RKIP suppresses the influenza A virusinduced airway inflammatory response via the ERK/MAPK pathway.
    Title: RKIP suppresses the influenza A virus‑induced airway inflammatory response via the ERK/MAPK pathway.
  3. Phosphatidylethanolamine-binding protein 1 (PEBP1) mediates the regulatory role of microRNAs (miRNAs)-205-5p in degranulation and histamine release.
    Title: Phosphatidylethanolamine-binding protein 1 (PEBP1) mediates the regulatory role of microRNAs (miRNAs)-205-5p in degranulation and histamine release.
  4. RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions.
    Title: RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions.
  5. Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage.
    Title: Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage.
  6. Transcriptional regulation of PEBP1 expression by androgen receptor in mouse testes.
    Title: Transcriptional regulation of PEBP1 expression by androgen receptor in mouse testes.
  7. Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
    Title: Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
  8. Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.
    Title: Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.
  9. Axonal Odorant Receptors Mediate Axon Targeting.
    Title: Axonal Odorant Receptors Mediate Axon Targeting.
  10. Theta power in the CA1 of HCNP-pp knockout mice was significantly reduced because of fewer cholineacetyltransferase-positive axons in the CA1 stratum oriens.
    Title: Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102065, MGC103131

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of acetylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of acetylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sperm capacitation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylethanolamine-binding protein 1
Names
HCNPpp
PEBP-1
Raf-1 inhibitor protein
Raf-1 kinase inhibitor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018858.2 → NP_061346.2  phosphatidylethanolamine-binding protein 1

    See identical proteins and their annotated locations for NP_061346.2

    Status: PROVISIONAL

    Source sequence(s)
    BC083063
    Consensus CDS
    CCDS39234.1
    UniProtKB/Swiss-Prot
    P70296, Q9D8G9, Q9JJ58
    UniProtKB/TrEMBL
    Q3TGC5, Q5EBQ2
    Related
    ENSMUSP00000048425.7, ENSMUST00000036951.13
    Conserved Domains (1) summary
    cd00866
    Location:25 → 171
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    117420716..117425629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70296.3 GenPept UniProtKB/Swiss-Prot:P70296

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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