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Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 [ Mus musculus (house mouse) ]

Gene ID: 23988, updated on 27-Nov-2024

Summary

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Official Symbol
Pin1provided by MGI
Official Full Name
peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1provided by MGI
Primary source
MGI:MGI:1346036
See related
Ensembl:ENSMUSG00000032171 AllianceGenome:MGI:1346036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D9Bwg1161e; 0610025L01Rik
Summary
Enables several functions, including beta-catenin binding activity; peptidyl-prolyl cis-trans isomerase activity; and phosphoprotein binding activity. Involved in several processes, including negative regulation of amyloid-beta formation; protein peptidyl-prolyl isomerization; and protein stabilization. Acts upstream of or within regulation of cell population proliferation and regulation of cytokinesis. Located in cytosol and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including 2-cell stage embryo; gut; nucleus pulposus; and reproductive system. Used to study Alzheimer's disease. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 15.3), CNS E18 (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pin1 in Genome Data Viewer
Location:
9 A3; 9 7.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20563335..20575008)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20652118..20663712)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene ubiquitin-like 5 Neighboring gene olfactomedin 2 Neighboring gene predicted gene, 39299 Neighboring gene predicted gene, 35860

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice. Risal P, et al. Pathol Int, 2012 Jan. PMID 22192799
  2. Pin1 mediates Aβ(42)-induced dendritic spine loss. Stallings NR, et al. Sci Signal, 2018 Mar 20. PMID 29559586, Free PMC Article
  3. Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells. Kurita-Suzuki A, et al. Biochem Biophys Res Commun, 2018 Feb 26. PMID 29432730
  4. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Liao Y, et al. Oncogene, 2009 Jul 2. PMID 19448664, Free PMC Article
  5. The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury. Kuboki S, et al. J Hepatol, 2009 Aug. PMID 19515451, Free PMC Article

See all (208) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation.
    Title: Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation.
  2. Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity.
    Title: Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity.
  3. Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice.
    Title: Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice.
  4. PIN1 protects auditory hair cells from senescence via autophagy.
    Title: PIN1 protects auditory hair cells from senescence via autophagy.
  5. Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism.
    Title: Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism.
  6. Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes.
    Title: Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes.
  7. Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.
    Title: Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.
  8. [Prolyl Isomerase Pin1 Impacts on Metabolism in Muscle and Adipocytes].
    Title: [Prolyl Isomerase Pin1 Impacts on Metabolism in Muscle and Adipocytes].
  9. Death-associated protein kinase 1 mediates Abeta42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
    Title: Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
  10. The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
    Title: The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
Submit: New GeneRIF Correction See all GeneRIFs (139)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal motor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphothreonine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin ligase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation protein catabolic process at postsynapse EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation protein catabolic process at postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation protein catabolic process at postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation protein catabolic process at postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Names
PPIase Pin1
peptidyl-prolyl cis-trans isomerase Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
rotamase Pin1
NP_001351424.1
NP_075860.1
XP_036010827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364495.1 → NP_001351424.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164565
    Conserved Domains (2) summary
    pfam00397
    Location:7 → 37
    WW; WW domain
    cl26124
    Location:53 → 129
    Rotamase_2; PPIC-type PPIASE domain

  2. NM_023371.4 → NP_075860.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1

    See identical proteins and their annotated locations for NP_075860.1

    Status: VALIDATED

    Source sequence(s)
    AK003931, AK054045
    Consensus CDS
    CCDS22882.1
    UniProtKB/Swiss-Prot
    Q543B3, Q9QUR7
    UniProtKB/TrEMBL
    Q3UTI7
    Related
    ENSMUSP00000034689.7, ENSMUST00000034689.8
    Conserved Domains (3) summary
    COG0760
    Location:55 → 161
    SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:7 → 37
    WW; WW domain
    cl08278
    Location:53 → 164
    Rotamase_2; PPIC-type PPIASE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20563335..20575008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154934.1 → XP_036010827.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

    Conserved Domains (2) summary
    pfam00397
    Location:7 → 37
    WW; WW domain
    cl29122
    Location:53 → 89
    Rotamase_2; PPIC-type PPIASE domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUR7.1 GenPept UniProtKB/Swiss-Prot:Q9QUR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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