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Zfp119b zinc finger protein 119b [ Mus musculus (house mouse) ]

Gene ID: 240120, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp119bprovided by MGI
Official Full Name
zinc finger protein 119bprovided by MGI
Primary source
MGI:MGI:2385323
See related
Ensembl:ENSMUSG00000062101 AllianceGenome:MGI:2385323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF630 (zinc finger protein 630) and ZNF90 (zinc finger protein 90). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 1.1), liver E18 (RPKM 0.8) and 28 other tissues See more
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Genomic context

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See Zfp119b in Genome Data Viewer
Location:
17 D; 17 29.07 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56245373..56263186, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55938373..55956233, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42873 Neighboring gene STARR-positive B cell enhancer ABC_E4220 Neighboring gene STARR-positive B cell enhancer ABC_E7546 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene Epstein-Barr virus induced gene 3 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC18735

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 119b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310337.1 → NP_001297266.1  zinc finger protein 119b isoform 2

    See identical proteins and their annotated locations for NP_001297266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154235
    Consensus CDS
    CCDS79564.1
    UniProtKB/TrEMBL
    A0A087WPI5
    Related
    ENSMUSP00000139791.2, ENSMUST00000189452.2
    Conserved Domains (3) summary
    COG5048
    Location:337 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:297 → 322
    zf-H2C2_2; Zinc-finger double domain

  2. NM_146249.4 → NP_666361.1  zinc finger protein 119b isoform 1

    See identical proteins and their annotated locations for NP_666361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC154235
    Consensus CDS
    CCDS37659.1
    UniProtKB/TrEMBL
    Q8K0G9
    Related
    ENSMUSP00000058300.8, ENSMUST00000056147.14
    Conserved Domains (5) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:369 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam13465
    Location:413 → 438
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56245373..56263186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246456.3 → XP_011244758.1  zinc finger protein 119b isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:396 → 552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400 → 420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:31 → 71
    KRAB; KRAB box
    pfam13465
    Location:356 → 381
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011246457.3 → XP_011244759.1  zinc finger protein 119b isoform X2

    See identical proteins and their annotated locations for XP_011244759.1

    UniProtKB/TrEMBL
    A0A087WPI5
    Conserved Domains (3) summary
    COG5048
    Location:337 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:297 → 322
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017317472.3 → XP_017172961.1  zinc finger protein 119b isoform X2

    UniProtKB/TrEMBL
    A0A087WPI5
    Conserved Domains (3) summary
    COG5048
    Location:337 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:297 → 322
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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