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nsy-1 Mitogen-activated protein kinase kinase kinase nsy-1;mitogen-activated protein kinase kinase kinase [ Caenorhabditis elegans ]

Gene ID: 24104671, updated on 4-Jan-2025

Summary

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Official Symbol
nsy-1
Official Full Name
Mitogen-activated protein kinase kinase kinase nsy-1;mitogen-activated protein kinase kinase kinase
Primary source
WormBase:WBGene00003822
Locus tag
CELE_F59A6.1
See related
AllianceGenome:WB:WBGene00003822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including AWC; hypodermis; intestine; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to several human genes including MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nsy-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (5022757..5029999)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene 50S ribosomal protein L29 Neighboring gene Uncharacterized protein Neighboring gene WD repeat domain-containing protein 83 Neighboring gene DUF1308 domain-containing protein Neighboring gene tRNA-Ile Neighboring gene Leucine-Rich Repeat protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans odour discrimination requires asymmetric diversity in olfactory neurons. Wes PD, et al. Nature, 2001 Apr 5. PMID 11287957
  2. C. elegans srf-6 and nsy-1 mutations result in a similar 2AWC(ON) phenotype and do not complement (srf-6 is nsy-1 II). Honzel B, et al. MicroPubl Biol, 2019 Jul 4. PMID 32550425, Free PMC Article
  3. Three C. elegans srf-6 mutants carry nsy-1 mutations (srf-6 is nsy-1 I). Van Sciver N, et al. MicroPubl Biol, 2019 Jul 4. PMID 32550407, Free PMC Article
  4. A Caenorhabditis elegans p38 MAP kinase pathway mutant protects from dopamine, methamphetamine, and MDMA toxicity. Schreiber MA, et al. Neurosci Lett, 2011 Jul 1. PMID 21565252, Free PMC Article
  5. Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Sifri CD, et al. Infect Immun, 2003 Apr. PMID 12654843, Free PMC Article

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of left/right asymmetry in nervous system IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of left/right asymmetry in nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nematicide TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mitogen-activated protein kinase kinase kinase nsy-1;mitogen-activated protein kinase kinase kinase
NP_001370698.1
  • Confirmed by transcript evidence
NP_001380179.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5022757..5029999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383826.1 → NP_001370698.1  Mitogen-activated protein kinase kinase kinase nsy-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21029
    Conserved Domains (3) summary
    cd06624
    Location:655 → 925
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:136 → 517
    DUF4071; Domain of unknown function (DUF4071)
    pfam19039
    Location:529 → 631
    ASK_PH; ASK kinase PH domain

  2. NM_001393063.1 → NP_001380179.1  mitogen-activated protein kinase kinase kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATZ5
    Conserved Domains (3) summary
    cd06624
    Location:641 → 911
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:122 → 503
    DUF4071; Domain of unknown function (DUF4071)
    pfam19039
    Location:515 → 617
    ASK_PH; ASK kinase PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21029.4

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