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elc-2 Elongin-C [ Caenorhabditis elegans ]

Gene ID: 24104987, updated on 9-Dec-2024

Summary

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Official Symbol
elc-2
Official Full Name
Elongin-C
Primary source
WormBase:WBGene00001237
Locus tag
CELE_W03H1.2
See related
AllianceGenome:WB:WBGene00001237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of elongin complex. Is expressed in serotonergic neurons. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See elc-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (1777288..1778088, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene pseudo Neighboring gene Delta-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation. Gracida X, et al. Cell Rep, 2017 Dec 12. PMID 29241538, Free PMC Article
  2. Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II. Sasagawa Y, et al. Chromosome Res, 2005. PMID 15973501
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of elongin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Elongin-C
NP_001362016.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1777288..1778088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001374969.2 → NP_001362016.1  Elongin-C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23153
    Conserved Domains (1) summary
    cd18321
    Location:48 → 141
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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