FJX1 four-jointed box kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FJX1provided by HGNC
Official Full Name: four-jointed box kinase 1provided by HGNC
Primary source: HGNC:HGNC:17166
See related: Ensembl:ENSG00000179431 MIM:612206; AllianceGenome:HGNC:17166
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 11p13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (35618460..35620865)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (35757225..35759630)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (35640008..35642413)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
Title: [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
MiR-532-3p suppresses cell proliferation, migration and invasion of colon adenocarcinoma via targeting FJX1.
Title: MiR-532-3p suppresses cell proliferation, migration and invasion of colon adenocarcinoma via targeting FJX1.
MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma.
Title: MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma.
FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis.
Title: FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis.
FJX1 transcript and protein level is upregulated in nasopharyngeal carcinoma tissue samples. FJX1 promotes cell proliferation, anchorage-dependent growth, and cellular invasion in vitro.
Title: An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma.
The results of our Western blot analysis reveal a significant positive correlation between FJX1 and HIF1alpha proteins in endometrium of women with and without endometriosis.
Title: Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis.
FJX1 does not influence the levels of FAT1 ectodomain phosphorylation.
Title: FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina layer formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: four-jointed box protein 1

Names: four jointed box 1; four-jointed protein homolog; putative secreted ligand homologous to fjx1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014344.4 → NP_055159.2 four-jointed box protein 1

See identical proteins and their annotated locations for NP_055159.2

Status: REVIEWED

Source sequence(s)

AK026069, BC049171

Consensus CDS

CCDS44570.1

UniProtKB/Swiss-Prot

B2RCA9, Q86VR8, Q9UGK6

Related

ENSP00000400223.1, ENST00000317811.6

Conserved Domains (1) summary

cd10468
Location:149 → 430

Four-jointed-like_C; C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins