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Lsm14b LSM family member 14B [ Mus musculus (house mouse) ]

Gene ID: 241846, updated on 27-Nov-2024

Summary

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Official Symbol
Lsm14bprovided by MGI
Official Full Name
LSM family member 14Bprovided by MGI
Primary source
MGI:MGI:3040677
See related
Ensembl:ENSMUSG00000039108 AllianceGenome:MGI:3040677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430078B04
Summary
Enables RNA binding activity. Involved in several processes, including maternal mRNA clearance; meiotic cell cycle process involved in oocyte maturation; and ovarian follicle development. Located in cytoplasmic ribonucleoprotein granule. Is expressed in several structures, including early embryo; facial prominence; liver; oocyte; and spleen. Orthologous to human LSM14B (LSM family member 14B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 57.0), whole brain E14.5 (RPKM 50.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lsm14b in Genome Data Viewer
Location:
2 H4; 2 102.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179666770..179677254)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180024900..180035466)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 4 Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene STARR-seq mESC enhancer starr_06725 Neighboring gene STARR-positive B cell enhancer ABC_E7896 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene proteasome subunit alpha 7 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LSM14B controls oocyte mRNA storage and stability to ensure female fertility. Shan LY, et al. Cell Mol Life Sci, 2023 Aug 14. PMID 37578641, Free PMC Article
  2. LSM14B coordinates protein component expression in the P-body and controls oocyte maturation. Zhang H, et al. J Genet Genomics, 2024 Jan. PMID 37481122
  3. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice. Li H, et al. Adv Sci (Weinh), 2023 Jun. PMID 37083226, Free PMC Article
  4. Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility. Ding Y, et al. Development, 2023 Dec 1. PMID 38088064
  5. Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body. Dhandapani L, et al. J Cell Sci, 2022 Dec 1. PMID 34897463

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.
    Title: LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.
  2. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.
    Title: LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.
  3. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice.
    Title: LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in maternal mRNA clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle process involved in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membraneless organelle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein LSM14 homolog B
Names
LSM14 homolog B
RNA-associated protein 55B
mRAP55B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372364.2 → NP_001359293.1  protein LSM14 homolog B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663067
    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:287 → 388
    FDF; FDF domain

  2. NM_001411271.1 → NP_001398200.1  protein LSM14 homolog B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663067

  3. NM_001411272.1 → NP_001398201.1  protein LSM14 homolog B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663067

  4. NM_001411273.1 → NP_001398202.1  protein LSM14 homolog B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663067

  5. NM_001411274.1 → NP_001398203.1  protein LSM14 homolog B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL663067

  6. NM_001411275.1 → NP_001398204.1  protein LSM14 homolog B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL663067

  7. NM_001411276.1 → NP_001398205.1  protein LSM14 homolog B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL663067

  8. NM_001411277.1 → NP_001398206.1  protein LSM14 homolog B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL663067

  9. NM_001411278.1 → NP_001398207.1  protein LSM14 homolog B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL663067

  10. NM_001411279.1 → NP_001398208.1  protein LSM14 homolog B isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL663067
    Related
    ENSMUSP00000062519.5, ENSMUST00000058764.6

  11. NM_177727.5 → NP_808395.2  protein LSM14 homolog B isoform 2

    See identical proteins and their annotated locations for NP_808395.2

    Status: VALIDATED

    Source sequence(s)
    AL663067
    Consensus CDS
    CCDS17165.2
    UniProtKB/Swiss-Prot
    A2AC71, Q8CGC4
    Related
    ENSMUSP00000055036.6, ENSMUST00000055485.12
    Conserved Domains (2) summary
    cd01736
    Location:6 → 79
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:248 → 349
    FDF; FDF domain

RNA

  1. NR_177201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663067

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179666770..179677254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGC4.3 GenPept UniProtKB/Swiss-Prot:Q8CGC4

Gene LinkOut

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