Aldh1a1 aldehyde dehydrogenase 1 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Aldh1a1provided by RGD
Full Name: aldehyde dehydrogenase 1 family, member A1provided by RGD
Primary source: RGD:2087
See related: EnsemblRapid:ENSRNOG00000017619 AllianceGenome:RGD:2087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ahd2; Aldh1; Aldh2
Summary: Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Predicted to be located in axon; cytosol; and synapse. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 2289.1), Testes (RPKM 1535.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q51

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (227426939..227579497)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (218000470..218152962)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (238222689..238264381)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by Thioredoxin-1.
Title: Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by Thioredoxin-1.
Loss of ALDH2 aggravates mitochondrial biogenesis disorder in cardiac myocytes induced by TAC.
Title: Loss of ALDH2 aggravates mitochondrial biogenesis disorder in cardiac myocytes induced by TAC.
ALDH2 attenuates ischemia and reperfusion injury through regulation of mitochondrial fusion and fission by PI3K/AKT/mTOR pathway in diabetic cardiomyopathy.
Title: ALDH2 attenuates ischemia and reperfusion injury through regulation of mitochondrial fusion and fission by PI3K/AKT/mTOR pathway in diabetic cardiomyopathy.
Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis of Acute Cerebral Infarction.
Title: Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis of Acute Cerebral Infarction.
Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage.
Title: Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage.
Data suggest that retinoic acid up-regulates Mdk gene expression via Rar signaling in neurons of anterior pituitary which also express Raldh1. (Mdk = midkine; Rar = retinoic acid receptor; Raldh1= retinaldehyde dehydrogenase 1)
Title: Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells.
downregulation of ALDH and AKR enzymes, particularly ALDH1a1, may contribute ALE accumulation in the diabetic retina.
Title: Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina.
Overexpression and inhibition of ALDH1A1 activity results in reduced and increased HNE toxicity, respectively.
Title: Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy-2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells.
The elevated hepatic expression of Raldh1 in Zucker fatty (obese) rats may cause the excessive retinoic acid production from retinol, and in turn, result in higher Srebp-1c expression.
Title: The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells.
Expression of RALDH1 in the adult pituitary gland was determined.
Title: Expression of retinaldehyde dehydrogenase 1 in the anterior pituitary glands of adult rats.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

Aldh1a1 (e-PCR), detects polymorphism
- UniSTS:470549

RH94633 (e-PCR)
- UniSTS:119880

Aldh1a1 (e-PCR), detects polymorphism
- UniSTS:186488

D1Bda57 (e-PCR)
- UniSTS:239810

RH137275 (e-PCR)
- UniSTS:219363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-chloroallyl aldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-chloroallyl aldehyde dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
enables 3-deoxyglucosone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-deoxyglucosone dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aminobutyraldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables aminobutyraldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aminobutyraldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables benzaldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables benzaldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 9-cis-retinoic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 9-cis-retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of aldehyde	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification of aldehyde	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in fructosamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructosamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fructose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of lens transparency	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in optic cup morphogenesis involved in camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aldehyde dehydrogenase 1A1

Names: 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; RALDH 1; aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase 2; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, subfamily A1; aldehyde dehydrogenase, cytosolic; ralDH1; retinal dehydrogenase 1

NP_071852.2

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

XP_038949786.1

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

XP_038949828.1

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

XP_038949859.1

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

XP_038949895.1

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

XP_063135997.1

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

XP_063136020.1

EC 1.2.1.19

EC 1.2.1.28

EC 1.2.1.3

EC 1.2.1.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022407.3 → NP_071852.2 aldehyde dehydrogenase 1A1

See identical proteins and their annotated locations for NP_071852.2

Status: PROVISIONAL

Source sequence(s)

AF001898

UniProtKB/Swiss-Prot

O09184, P51647

UniProtKB/TrEMBL

A0A0H2UHP1, A6I0L3

Related

ENSRNOP00000024000.6, ENSRNOT00000024000.8

Conserved Domains (1) summary

cd07141
Location:15 → 495

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

227426939..227579497

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093858.2 → XP_038949786.1 aldehyde dehydrogenase 1A1 isoform X1

UniProtKB/TrEMBL

A0A0H2UHP1, A0A8I6AP49

Conserved Domains (1) summary

cd07141
Location:34 → 514

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
XM_039093931.2 → XP_038949859.1 aldehyde dehydrogenase 1A1 isoform X2

UniProtKB/Swiss-Prot

O09184, P51647

UniProtKB/TrEMBL

A0A0H2UHP1, A6I0L3

Conserved Domains (1) summary

cd07141
Location:15 → 495

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
XM_039093900.2 → XP_038949828.1 aldehyde dehydrogenase 1A1 isoform X1

UniProtKB/TrEMBL

A0A0H2UHP1, A0A8I6AP49

Conserved Domains (1) summary

cd07141
Location:34 → 514

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
XM_063279927.1 → XP_063135997.1 aldehyde dehydrogenase 1A1 isoform X1

UniProtKB/TrEMBL

A0A8I6AP49
XM_063279950.1 → XP_063136020.1 aldehyde dehydrogenase 1A1 isoform X1

UniProtKB/TrEMBL

A0A8I6AP49

Related

ENSRNOP00000090793.1, ENSRNOT00000112107.2
XM_039093967.2 → XP_038949895.1 aldehyde dehydrogenase 1A1 isoform X2

UniProtKB/Swiss-Prot

O09184, P51647

UniProtKB/TrEMBL

A0A0H2UHP1, A6I0L3

Conserved Domains (1) summary

cd07141
Location:15 → 495

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like