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Slc22a15 solute carrier family 22 (organic anion/cation transporter), member 15 [ Mus musculus (house mouse) ]

Gene ID: 242126, updated on 27-Nov-2024

Summary

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Official Symbol
Slc22a15provided by MGI
Official Full Name
solute carrier family 22 (organic anion/cation transporter), member 15provided by MGI
Primary source
MGI:MGI:3607704
See related
Ensembl:ENSMUSG00000033147 AllianceGenome:MGI:3607704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930477M19; 2610034P21Rik; A530052I06Rik
Summary
Enables amino-acid betaine transmembrane transporter activity. Predicted to be involved in several processes, including amino acid transport; amino-acid betaine transport; and monoatomic ion transport. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and urinary system. Orthologous to human SLC22A15 (solute carrier family 22 member 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 8.5), colon adult (RPKM 2.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Slc22a15 in Genome Data Viewer
Location:
3 F2.2; 3 44.3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101763084..101831769, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101854443..101928220, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08546 Neighboring gene STARR-seq mESC enhancer starr_08547 Neighboring gene predicted gene, 33309 Neighboring gene STARR-positive B cell enhancer ABC_E6090 Neighboring gene mab-21-like 3 Neighboring gene predicted gene, 33381 Neighboring gene STARR-seq mESC enhancer starr_08552 Neighboring gene STARR-seq mESC enhancer starr_08553 Neighboring gene STARR-seq mESC enhancer starr_08554 Neighboring gene nescient helix loop helix 2 Neighboring gene STARR-seq mESC enhancer starr_08555 Neighboring gene STARR-seq mESC enhancer starr_08556 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer. Nayak D, et al. iScience, 2022 May 20. PMID 35479410, Free PMC Article
  2. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. Yee SW, et al. FASEB J, 2020 Dec. PMID 33124720, Free PMC Article
  3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino-acid betaine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino-acid betaine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino-acid betaine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 15
Names
solute carrier family 22 (organic cation transporter), member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039371.2 → NP_001034460.2  solute carrier family 22 member 15

    See identical proteins and their annotated locations for NP_001034460.2

    Status: VALIDATED

    Source sequence(s)
    AC165165
    Consensus CDS
    CCDS51022.1
    UniProtKB/Swiss-Prot
    A7MCW2, F8WJ00, Q504N2, Q8CDR3
    Related
    ENSMUSP00000102541.3, ENSMUST00000106928.10
    Conserved Domains (1) summary
    cd06174
    Location:121 → 469
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    101763084..101831769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039369.1: Suppressed sequence

    Description
    NM_001039369.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

  2. NM_001039370.1: Suppressed sequence

    Description
    NM_001039370.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

  3. NM_177729.2: Suppressed sequence

    Description
    NM_177729.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504N2.3 GenPept UniProtKB/Swiss-Prot:Q504N2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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