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Tspo translocator protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24230, updated on 27-Nov-2024

Summary

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Official Symbol
Tspoprovided by RGD
Official Full Name
translocator proteinprovided by RGD
Primary source
RGD:2228
See related
EnsemblRapid:ENSRNOG00000010549 AllianceGenome:RGD:2228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MBR; Bzrp; Ptbzr; PTBZR02; RATPTBZR02
Summary
Enables androgen binding activity and benzodiazepine receptor activity. Involved in several processes, including neurogenesis; positive regulation of programmed cell death; and regulation of glial cell proliferation. Located in mitochondrial outer membrane. Used to study cholesterol ester storage disease. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 1092.6), Lung (RPKM 365.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspo in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116600214..116610461)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114720188..114730450)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124460358..124470610)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479952 Neighboring gene uncharacterized LOC134479950 Neighboring gene malonyl-CoA-acyl carrier protein transacylase Neighboring gene tubulin tyrosine ligase like 12 Neighboring gene uncharacterized LOC134479949 Neighboring gene signal peptide, CUB domain and EGF like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats. Yanamoto K, et al. Neurosci Lett, 2007 Nov 27. PMID 17959307
  2. Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. Kunduzova OR, et al. J Am Soc Nephrol, 2004 Aug. PMID 15284300
  3. The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Levin E, et al. Biochemistry, 2005 Jul 26. PMID 16026165
  4. Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mills CD, et al. Mol Cell Neurosci, 2005 Oct. PMID 16099172
  5. The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. Azarashvili T, et al. Cell Calcium, 2007 Jul. PMID 17174393

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia-reperfusion: role of TSPO and STAR.
    Title: Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia-reperfusion: role of TSPO and STAR.
  2. TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes.
    Title: TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes.
  3. TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction.
    Title: TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction.
  4. Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
    Title: Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
  5. Translocator protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2-dependent antioxidant system and promoting autophagy.
    Title: Translocator protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2-dependent antioxidant system and promoting autophagy.
  6. TSPO Expression Modulatory Effect of Acetylcholinesterase Inhibitor in the Ischemic Stroke Rat Model.
    Title: TSPO Expression Modulatory Effect of Acetylcholinesterase Inhibitor in the Ischemic Stroke Rat Model.
  7. TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.
    Title: TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.
  8. The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats.
    Title: The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats.
  9. TSPO expression is up-regulated under anoxia/reoxygenation injury, and repression of TSPO improves the endurance of cardiomyocytes.
    Title: Downregulation of TSPO expression inhibits oxidative stress and maintains mitochondrial homeostasis in cardiomyocytes subjected to anoxia/reoxygenation injury.
  10. Study found no alcohol use disorder (AUD) group differences on [11C]PBR28 binding in our clinical study and no group differences in [11C]PBR28 uptake in the brain of alcohol-dependent versus -nondependent rats. However, when separately analyzing by TSPO genotype, found lower [11C]PBR28 binding in the brain of AUD patients than in healthy controls for medium-affinity binders only.
    Title: Influence of alcoholism and cholesterol on TSPO binding in brain: PET [(11)C]PBR28 studies in humans and rodents.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables androgen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables benzodiazepine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adrenal gland development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular hypotonic response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in contact inhibition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in glial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of protein location in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of corticosterone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peripheral nervous system axon regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mitochondrial depolarization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to acetylcholine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to manganese ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to pain IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to vitamin B1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
translocator protein
Names
Benzodiazepin receptor (peripheral)
PBR
PKBS
benzodiazepine receptor, peripheral
mitochondrial benzodiazepine receptor
peripheral-type benzodiazepine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012515.2 → NP_036647.1  translocator protein

    See identical proteins and their annotated locations for NP_036647.1

    Status: VALIDATED

    Source sequence(s)
    BQ194961, FM047408, J05122
    UniProtKB/Swiss-Prot
    P16257
    UniProtKB/TrEMBL
    A6HTA0
    Related
    ENSRNOP00000014089.1, ENSRNOT00000014089.6
    Conserved Domains (1) summary
    pfam03073
    Location:12 → 155
    TspO_MBR; TspO/MBR family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116600214..116610461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078393.2 → XP_038934321.1  translocator protein isoform X1

    UniProtKB/Swiss-Prot
    P16257
    UniProtKB/TrEMBL
    A6HTA0
    Conserved Domains (1) summary
    pfam03073
    Location:12 → 155
    TspO_MBR; TspO/MBR family

  2. XM_039078394.2 → XP_038934322.1  translocator protein isoform X1

    UniProtKB/Swiss-Prot
    P16257
    UniProtKB/TrEMBL
    A6HTA0
    Conserved Domains (1) summary
    pfam03073
    Location:12 → 155
    TspO_MBR; TspO/MBR family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16257.1 GenPept UniProtKB/Swiss-Prot:P16257

Gene LinkOut

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