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Cpb1 carboxypeptidase B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24271, updated on 27-Nov-2024

Summary

Official Symbol
Cpb1provided by RGD
Official Full Name
carboxypeptidase B1provided by RGD
Primary source
RGD:2391
See related
EnsemblRapid:ENSRNOG00000030904 AllianceGenome:RGD:2391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cpb
Summary
Enables carboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasmic vesicle. Predicted to be active in extracellular space. Orthologous to human CPB1 (carboxypeptidase B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 7904.1) and Liver (RPKM 2563.9) See more
Orthologs
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Genomic context

See Cpb1 in Genome Data Viewer
Location:
2q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104684275..104744824, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102755241..102785628, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (105059293..105089682, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4 gamma 1, pseudogene 1 Neighboring gene carboxypeptidase A3 Neighboring gene angiotensin II receptor, type 1b Neighboring gene uncharacterized LOC103690087 Neighboring gene uncharacterized LOC120100782

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
carboxypeptidase B
Names
carboxypeptidase B1 (tissue)
pancreatic carboxypeptidase B1
NP_036665.2
XP_063137358.1
XP_063137359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012533.2NP_036665.2  carboxypeptidase B precursor

    Status: VALIDATED

    Source sequence(s)
    AW916086, CF249065, CF249171, JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P19223
    Related
    ENSRNOP00000048109.3, ENSRNOT00000043381.5
    Conserved Domains (2) summary
    cd03871
    Location:112410
    M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
    pfam02244
    Location:33102
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    104684275..104744824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281288.1XP_063137358.1  carboxypeptidase B isoform X1

    UniProtKB/TrEMBL
    A6IHD4, D3ZAM3
  2. XM_063281289.1XP_063137359.1  carboxypeptidase B isoform X1

    UniProtKB/TrEMBL
    A6IHD4, D3ZAM3