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Slc45a1 solute carrier family 45, member 1 [ Mus musculus (house mouse) ]

Gene ID: 242773, updated on 27-Nov-2024

Summary

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Official Symbol
Slc45a1provided by MGI
Official Full Name
solute carrier family 45, member 1provided by MGI
Primary source
MGI:MGI:2653235
See related
Ensembl:ENSMUSG00000039838 AllianceGenome:MGI:2653235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnb5; PAST-A; C230078B22
Summary
Enables D-glucose:proton symporter activity. Involved in D-glucose transmembrane transport. Predicted to be active in membrane. Is expressed in medulla oblongata basal plate and ventral grey horn. Orthologous to human SLC45A1 (solute carrier family 45 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 14.7), cortex adult (RPKM 10.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Slc45a1 in Genome Data Viewer
Location:
4 E2; 4 81.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150713853..150736614, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150629396..150652176, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene arginine glutamic acid dipeptide (RE) repeats Neighboring gene RIKEN cDNA E230012J19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:149809745-149810046 Neighboring gene STARR-seq mESC enhancer starr_12156 Neighboring gene predicted gene, 52709 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149919109-149919262 Neighboring gene STARR-positive B cell enhancer ABC_E6288 Neighboring gene STARR-positive B cell enhancer ABC_E2732 Neighboring gene STARR-seq mESC enhancer starr_12163 Neighboring gene STARR-seq mESC enhancer starr_12165 Neighboring gene STARR-seq mESC enhancer starr_12167 Neighboring gene STARR-seq mESC enhancer starr_12169 Neighboring gene predicted gene, 36600 Neighboring gene predicted gene, 54271

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Srour M, et al. Am J Hum Genet, 2017 May 4. PMID 28434495, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables D-glucose:proton symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables D-glucose:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables D-glucose:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables galactose:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables galactose:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sucrose:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proton-associated sugar transporter A
Names
DNb-5 homolog
deleted in neuroblastoma 5 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355737.2 → NP_001342666.1  proton-associated sugar transporter A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606982
    Conserved Domains (1) summary
    cl28910
    Location:324 → 546
    MFS; Major Facilitator Superfamily

  2. NM_001425825.1 → NP_001412754.1  proton-associated sugar transporter A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606982

  3. NM_001425826.1 → NP_001412755.1  proton-associated sugar transporter A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606982

  4. NM_001425827.1 → NP_001412756.1  proton-associated sugar transporter A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606982

  5. NM_173774.4 → NP_776135.2  proton-associated sugar transporter A isoform 1

    See identical proteins and their annotated locations for NP_776135.2

    Status: VALIDATED

    Source sequence(s)
    AL606982
    Consensus CDS
    CCDS18973.1
    UniProtKB/Swiss-Prot
    Q3TZ98, Q8BIV7
    UniProtKB/TrEMBL
    B0QZL3
    Related
    ENSMUSP00000036774.4, ENSMUST00000037827.10
    Conserved Domains (1) summary
    TIGR01301
    Location:83 → 293
    GPH_sucrose; GPH family sucrose/H+ symporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    150713853..150736614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIV7.3 GenPept UniProtKB/Swiss-Prot:Q8BIV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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