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Fgg fibrinogen gamma chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 24367, updated on 27-Nov-2024

Summary

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Official Symbol
Fggprovided by RGD
Official Full Name
fibrinogen gamma chainprovided by RGD
Primary source
RGD:2613
See related
EnsemblRapid:ENSRNOG00000025074 AllianceGenome:RGD:2613
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables identical protein binding activity. Involved in cellular response to interleukin-1; cellular response to interleukin-6; and platelet maturation. Located in blood microparticle. Biomarker of obesity; pancreatitis; and pulmonary embolism. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Orthologous to human FGG (fibrinogen gamma chain). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 12640.2) See more
Orthologs
human mouse all
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Genomic context

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See Fgg in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (170652929..170660372)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (168354880..168362325)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (181987080..181994523)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 46 Neighboring gene uncharacterized LOC102555909 Neighboring gene lecithin retinol acyltransferase Neighboring gene uncharacterized LOC134485930 Neighboring gene fibrinogen alpha chain Neighboring gene fibrinogen beta chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of plasma from rats following total parenteral nutrition-induced liver injury. Tsai JJ, et al. Proteomics, 2015 Nov. PMID 26314240
  2. Developmental expression of mRNAs encoding platelet proteins in rat megakaryocytes. Courtney MA, et al. Blood, 1991 Feb 1. PMID 1991167
  3. Nucleotide sequence of the gamma chain gene of rat fibrinogen: conserved intronic sequences. Morgan JG, et al. Nucleic Acids Res, 1987 Mar 25. PMID 3562236, Free PMC Article
  4. Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogen. Crabtree GR, et al. Cell, 1982 Nov. PMID 6897622
  5. A G-to-A mutation in IVS-3 of the human gamma fibrinogen gene causing afibrinogenemia due to abnormal RNA splicing. Margaglione M, et al. Blood, 2000 Oct 1. PMID 11001903

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in macrophage IL-18 and vascular fibrinogen deopsition following injury in aging rats contribute to local inflammation and postinjury neointima formation.
    Title: Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflammatory signatures of vascular remodeling.
  2. FGG dimerization increased on day 6 of pregnancy, dependent on the presence of a developing blastocyst
    Title: ICAM1 and fibrinogen-γ are increased in uterine epithelial cells at the time of implantation in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in fibrinolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet maturation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in blood microparticle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of fibrinogen complex ISO
Inferred from Sequence Orthology
more info
  
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fibrinogen gamma chain
Names
fibrinogen, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012559.2 → NP_036691.2  fibrinogen gamma chain precursor

    See identical proteins and their annotated locations for NP_036691.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078893
    UniProtKB/TrEMBL
    A6J5U7
    Related
    ENSRNOP00000082495.2, ENSRNOT00000115976.2
    Conserved Domains (2) summary
    pfam08702
    Location:31 → 172
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:175 → 414
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    170652929..170660372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232525.1 → XP_006232587.1  fibrinogen gamma chain isoform X1

    See identical proteins and their annotated locations for XP_006232587.1

    UniProtKB/Swiss-Prot
    P02680, Q68FY3
    UniProtKB/TrEMBL
    A6J5U8
    Related
    ENSRNOP00000100300.1, ENSRNOT00000140167.1
    Conserved Domains (2) summary
    pfam00147
    Location:175 → 414
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam08702
    Location:31 → 172
    Fib_alpha; Fibrinogen alpha/beta chain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02680.3 GenPept UniProtKB/Swiss-Prot:P02680

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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